Published in J Nat Prod on March 26, 2010
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Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc Natl Acad Sci U S A (2012) 2.69
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Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41. J Mol Biol (2005) 1.15
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Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41. PLoS Pathog (2010) 1.14
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. Virology (2008) 1.11
Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem (2003) 1.08
Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. J Nat Prod (2011) 1.06
Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry. J Org Chem (2009) 1.05
Structural basis for norovirus inhibition and fucose mimicry by citrate. J Virol (2011) 1.05
A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains. J Virol (2007) 1.05
Crambescidin 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp. that inhibit HIV-1 fusion. J Nat Prod (2003) 1.02
Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ. J Am Chem Soc (2010) 1.01
Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa. J Nat Prod (2002) 1.00
Differential inhibition of HIV-1 and SIV envelope-mediated cell fusion by C34 peptides derived from the C-terminal heptad repeat of gp41 from diverse strains of HIV-1, HIV-2, and SIV. J Med Chem (2005) 0.99
Natural products, small molecules, and genetics in tuberculosis drug development. J Med Chem (2008) 0.98
Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorg Med Chem Lett (2002) 0.96
Temperature-dependent intermediates in HIV-1 envelope glycoprotein-mediated fusion revealed by inhibitors that target N- and C-terminal helical regions of HIV-1 gp41. Biochemistry (2004) 0.96
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. Bioorg Med Chem (2008) 0.96
Engineering an obligate domain-swapped dimer of cyanovirin-N with enhanced anti-HIV activity. J Am Chem Soc (2002) 0.96
Solution structure of the monovalent lectin microvirin in complex with Man(alpha)(1-2)Man provides a basis for anti-HIV activity with low toxicity. J Biol Chem (2011) 0.96
Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants. J Mol Biol (2002) 0.96
Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species. J Org Chem (2010) 0.95
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Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. ACS Chem Biol (2011) 0.94
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase. J Med Chem (2007) 0.93
Research achievement award--D. John Faulkner. J Nat Prod (2004) 0.91
A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption. Biochemistry (2013) 0.90
Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J Biol Chem (2012) 0.89
Motualevic acids A-F, antimicrobial acids from the sponge Siliquariaspongia sp. Org Lett (2009) 0.89
Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin. Mol Cancer Ther (2011) 0.88
Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41. J Mol Biol (2006) 0.88
Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening. J Biomol Screen (2009) 0.88
Targeting the OB-Folds of Replication Protein A with Small Molecules. J Nucleic Acids (2010) 0.88
Synthetic macrolides that inhibit breast cancer cell migration in vitro. J Am Chem Soc (2007) 0.87
Mirabalin, [corrected] an antitumor macrolide lactam from the marine sponge Siliquariaspongia mirabilis. J Nat Prod (2008) 0.87
Paltolides A--C, anabaenopeptin-type peptides from the palau sponge Theonella swinhoei. J Nat Prod (2010) 0.86
HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth. Expert Opin Ther Targets (2015) 0.86
Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr Purif (2006) 0.85
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorg Med Chem (2013) 0.83
Total synthesis and proof of structure of mycothiol bimane. J Am Chem Soc (2002) 0.82
N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide. Org Lett (2008) 0.81
Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments. Mar Drugs (2012) 0.81
Molecular signatures of phytol-derived immunostimulants in the context of chemokine-cytokine microenvironment and enhanced immune response. Cell Immunol (2011) 0.79
Design and synthesis of substrate-mimic inhibitors of mycothiol-S-conjugate amidase from Mycobacterium tuberculosis. Bioorg Med Chem Lett (2006) 0.79
Synthesis of 1-D- and 1-L-myo-inosityl 2-N-acetamido-2-deoxy-alpha-D-glucopyranoside establishes substrate specificity of the Mycobacterium tuberculosis enzyme AcGI deacetylase. Bioorg Med Chem (2003) 0.79
Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL. J Am Chem Soc (2009) 0.78
Solution conformations of mycothiol bimane, 1-D-GlcNAc-alpha-(1 --> 1)-D-myo-Ins and 1-D-GlcNAc-alpha-(1 --> 1)-L-myo-Ins. J Org Chem (2003) 0.78
Synthetic adjuvants for vaccine formulations: evaluation of new phytol derivatives in induction and persistence of specific immune response. Cell Immunol (2011) 0.77
Phytochemical investigation and in vitro cytotoxic evaluation of alkaloids from Abuta rufescens. Planta Med (2011) 0.77
Characterization and carbohydrate specificity of pradimicin S. J Am Chem Soc (2012) 0.77
Synthesis of a bromotyrosine-derived natural product inhibitor of mycothiol-S-conjugate amidase. Bioorg Med Chem Lett (2004) 0.77
Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy. J Biomol NMR (2011) 0.77
Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor. J Med Chem (2012) 0.77
Mammalian expression of isotopically labeled proteins for NMR spectroscopy. Adv Exp Med Biol (2012) 0.76
Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosis. J Immunol (2012) 0.76
Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function. Angew Chem Int Ed Engl (2015) 0.76
Efficacy of phytol-derived diterpenoid immunoadjuvants over alum in shaping the murine host's immune response to Staphylococcus aureus. Vaccine (2013) 0.76
Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors. Bioorg Med Chem Lett (2011) 0.76
Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. PLoS Pathog (2016) 0.75
Polyethylene glycol-based homologated ligands for nicotinic acetylcholine receptors. Bioorg Med Chem (2008) 0.75
Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships. Bioorg Med Chem Lett (2010) 0.75
Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry. Bioorg Med Chem Lett (2010) 0.75
Isolation, structure elucidation, and biological evaluation of 15-amido-3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine, a new alkaloid from Hyperbaena valida. J Nat Prod (2006) 0.75
Characterization of beta-leptinotarsin-h and the effects of calcium flux antagonists on its activity. Toxicon (2005) 0.75
A model for cell-surface-exposed carbohydrate moieties suitable for structural studies by NMR spectroscopy. Chembiochem (2006) 0.75
Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro. Environ Sci Technol (2016) 0.75