1
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
Nature
|
2011
|
13.25
|
2
|
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
Nat Genet
|
2011
|
4.04
|
3
|
Meta-analysis identifies common variants associated with body mass index in east Asians.
|
Nat Genet
|
2012
|
2.70
|
4
|
An association between decreased estimated glomerular filtration rate and arterial stiffness.
|
Intern Med
|
2008
|
1.75
|
5
|
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
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Hypertens Res
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2008
|
1.72
|
6
|
Association of central systolic blood pressure with intracerebral small vessel disease in Japanese.
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Am J Hypertens
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2010
|
1.59
|
7
|
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
|
Hum Mol Genet
|
2006
|
1.50
|
8
|
Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients.
|
Am J Hypertens
|
2009
|
1.50
|
9
|
Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study.
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Hypertens Res
|
2009
|
1.47
|
10
|
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.
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Hum Mol Genet
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2007
|
1.44
|
11
|
Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.
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Diabetes Care
|
2007
|
1.34
|
12
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Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men.
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Atherosclerosis
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2010
|
1.31
|
13
|
Radial augmentation index: a useful and easily obtainable parameter for vascular aging.
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Am J Hypertens
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2005
|
1.12
|
14
|
A genome-wide association study of hypertension-related phenotypes in a Japanese population.
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Circ J
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2010
|
1.10
|
15
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The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.
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J Hum Genet
|
2010
|
1.08
|
16
|
Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors.
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Drug Metab Pharmacokinet
|
2004
|
1.07
|
17
|
Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.
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Biochem Biophys Res Commun
|
2005
|
1.07
|
18
|
MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study.
|
Stroke
|
2003
|
1.05
|
19
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Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
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Hypertension
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2013
|
1.03
|
20
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Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases.
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J Physiol
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2009
|
1.02
|
21
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Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study.
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Dement Geriatr Cogn Disord
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2010
|
1.02
|
22
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TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance.
|
Cell Metab
|
2011
|
1.02
|
23
|
Association of endothelin-1 gene variant with hypertension.
|
Hypertension
|
2003
|
1.02
|
24
|
An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.
|
Eur J Hum Genet
|
2006
|
1.02
|
25
|
High-sensitivity C-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons.
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Cardiovasc Diabetol
|
2010
|
1.02
|
26
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Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation.
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Hypertension
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2012
|
0.98
|
27
|
Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject.
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Hypertens Res
|
2009
|
0.95
|
28
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Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations.
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Diabetes
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2013
|
0.93
|
29
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Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people.
|
Hypertension
|
2010
|
0.93
|
30
|
Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia.
|
Hum Genet
|
2012
|
0.93
|
31
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Effects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adult population.
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Arthritis Care Res (Hoboken)
|
2014
|
0.93
|
32
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Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults.
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Lipids Health Dis
|
2011
|
0.92
|
33
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Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults.
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Cardiovasc Diabetol
|
2012
|
0.92
|
34
|
Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.
|
Am J Hum Genet
|
2013
|
0.91
|
35
|
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
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Hum Mol Genet
|
2013
|
0.91
|
36
|
Mutation of the follicle-stimulating hormone receptor gene 5'-untranslated region associated with female hypertension.
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Hypertension
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2006
|
0.91
|
37
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Serum uric acid is more strongly associated with impaired fasting glucose in women than in men from a community-dwelling population.
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PLoS One
|
2013
|
0.89
|
38
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Hematological parameters are associated with metabolic syndrome in Japanese community-dwelling persons.
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Endocrine
|
2013
|
0.89
|
39
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Methyl-CpG binding protein 2 gene (MECP2) variations in Japanese patients with Rett syndrome: pathological mutations and polymorphisms.
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Brain Dev
|
2005
|
0.89
|
40
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Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes.
|
Diabetes
|
2007
|
0.88
|
41
|
An association between metabolic syndrome and the estimated glomerular filtration rate.
|
Intern Med
|
2008
|
0.87
|
42
|
Association between fasting plasma glucose and high-sensitivity C-reactive protein: gender differences in a Japanese community-dwelling population.
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Cardiovasc Diabetol
|
2011
|
0.87
|
43
|
High prevalence of prehypertension is associated with the increased body mass index in community-dwelling Japanese.
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Tohoku J Exp Med
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2008
|
0.87
|
44
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Microalbuminuria and arterial stiffness in a general population: the Shimanami Health Promoting Program (J-SHIPP) study.
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Hypertens Res
|
2004
|
0.87
|
45
|
A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.
|
PLoS One
|
2010
|
0.87
|
46
|
An association between body mass index and estimated glomerular filtration rate.
|
Hypertens Res
|
2008
|
0.87
|
47
|
Asymptomatic cerebral microbleeds seen in healthy subjects have a strong association with asymptomatic lacunar infarction.
|
Circ J
|
2009
|
0.86
|
48
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Arterial stiffness in sarcopenic visceral obesity in the elderly: J-SHIPP study.
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Int J Cardiol
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2012
|
0.86
|
49
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Serum gamma-glutamyl transferase levels are associated with metabolic syndrome in community-dwelling individuals.
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J Atheroscler Thromb
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2009
|
0.85
|
50
|
Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population.
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Geriatr Gerontol Int
|
2010
|
0.85
|
51
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Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men.
|
Tohoku J Exp Med
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2008
|
0.85
|
52
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Synergistic influence of age and serum uric acid on blood pressure among community-dwelling Japanese women.
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Hypertens Res
|
2013
|
0.84
|
53
|
Association of GNAS1 gene variant with hypertension depending on smoking status.
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Hypertension
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2002
|
0.84
|
54
|
Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults.
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Lipids Health Dis
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2010
|
0.84
|
55
|
Home blood pressure is a better predictor of carotid atherosclerosis than office blood pressure in community-dwelling subjects.
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Hypertens Res
|
2004
|
0.84
|
56
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Migraine is associated with enhanced arterial stiffness.
|
Hypertens Res
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2007
|
0.84
|
57
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A slightly low hemoglobin level is beneficially associated with arterial stiffness in Japanese community-dwelling women.
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Clin Exp Hypertens
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2011
|
0.84
|
58
|
Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women.
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Endocrine
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2013
|
0.83
|
59
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Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study.
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Hypertens Res
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2009
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0.83
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60
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Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese.
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Circ J
|
2010
|
0.83
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61
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Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes.
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PLoS One
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2011
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0.83
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62
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Interaction between serum uric acid and triglycerides in relation to prehypertension in community-dwelling Japanese adults.
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Clin Exp Hypertens
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2013
|
0.83
|
63
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CDH13 genotype-dependent association of high-molecular weight adiponectin with all-cause mortality: the J-SHIPP study.
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Diabetes Care
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2013
|
0.82
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64
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A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes.
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Endocr J
|
2009
|
0.82
|
65
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Classic Rett syndrome in a boy with R133C mutation of MECP2.
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Brain Dev
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2005
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0.82
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66
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High-resolution mapping for essential hypertension using microsatellite markers.
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Hypertension
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2007
|
0.82
|
67
|
PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.
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Clin Endocrinol (Oxf)
|
2008
|
0.82
|
68
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Serum resistin is reduced by glucose and meal loading in healthy human subjects.
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Metabolism
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2008
|
0.82
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69
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Postural instability is associated with brain atrophy and cognitive impairment in the elderly: the J-SHIPP study.
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Dement Geriatr Cogn Disord
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2010
|
0.82
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70
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Blood pressure is the main determinant of the reflection wave in patients with type 2 diabetes.
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Hypertens Res
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2008
|
0.82
|
71
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Identification of a genetic variant at 2q12.1 associated with blood pressure in East Asians by genome-wide scan including gene-environment interactions.
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BMC Med Genet
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2014
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0.82
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72
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Serum high molecular weight adiponectin correlates with arterial stiffness in community-dwelling persons.
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Endocr Res
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2011
|
0.81
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73
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Smoking status is associated with serum high molecular adiponectin levels in community-dwelling Japanese men.
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J Atheroscler Thromb
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2010
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0.81
|
74
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Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.
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Clin Endocrinol (Oxf)
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2008
|
0.81
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75
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Association of angiotensin II type 2 receptor gene variant with hypertension.
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Hypertens Res
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2003
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0.81
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76
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Serum high molecular weight adiponectin is associated with mild renal dysfunction in Japanese adults.
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J Atheroscler Thromb
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2010
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0.81
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77
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Chlamydia pneumoniae seropositivity is associated with increased plasma levels of soluble cellular adhesion molecules in community-dwelling subjects: the Shimanami Health Promoting Program (J-SHIPP) study.
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Stroke
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2002
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0.80
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78
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Association of TNFRSF4 gene polymorphisms with essential hypertension.
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J Hypertens
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2008
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0.80
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79
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Association of serum high molecular weight adiponectin and blood pressure among non-diabetic community-dwelling men.
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Clin Exp Hypertens
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2011
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0.80
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80
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Insulin resistance and prevalence of prehypertension and hypertension among community-dwelling persons.
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J Atheroscler Thromb
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2010
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0.80
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81
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Serum gamma-glutamyl transferase within its normal concentration range is related to the presence of impaired fasting glucose and diabetes among Japanese community-dwelling persons.
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Endocr Res
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2011
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0.80
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82
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A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.
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Am J Hum Genet
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2012
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0.80
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83
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Association between antinuclear antibodies and the HLA class II locus and heterogeneous characteristics of staining patterns: the Nagahama study.
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Arthritis Rheumatol
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2014
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0.80
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84
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Plasma hepatocyte growth factor and the relationship between risk factors and carotid atherosclerosis.
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Hypertens Res
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2002
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0.79
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85
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Hemoglobin is associated with serum high molecular weight adiponectin in Japanese community-dwelling persons.
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J Atheroscler Thromb
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2010
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0.79
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86
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Alcohol drinking status is associated with serum high molecular weight adiponectin in community-dwelling Japanese men.
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J Atheroscler Thromb
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2010
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0.79
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87
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Increased high-density lipoprotein cholesterol is associated with a high prevalence of pre-hypertension and hypertension in community-dwelling persons.
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Endocrine
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2012
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0.79
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88
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Relationship between metabolic syndrome and Trp64arg polymorphism of the beta-adrenergic receptor gene in a general sample: the Shigaraki study.
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Hypertens Res
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2006
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0.78
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89
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Association of SLC6A9 gene variants with human essential hypertension.
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J Atheroscler Thromb
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2009
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0.78
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90
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Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese.
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Hypertens Res
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2006
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0.78
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91
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Low-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia.
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Menopause
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2012
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0.78
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92
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An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke.
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J Stroke Cerebrovasc Dis
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2007
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0.78
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93
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Genetic predisposition to neurological symptoms in lacunar infarction.
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Cerebrovasc Dis
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2004
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0.78
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94
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Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects: J-SHIPP study.
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Geriatr Gerontol Int
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2012
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0.78
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95
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Central blood pressure relates more strongly to retinal arteriolar narrowing than brachial blood pressure: the Nagahama Study.
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J Hypertens
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2015
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0.78
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96
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Portable indices for sarcopenia are associated with pressure wave reflection and central pulse pressure: the J-SHIPP study.
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J Hypertens
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2015
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0.78
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97
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Association of GNB3 gene with pulse pressure and clustering of risk factors for cardiovascular disease in Japanese.
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Biochem Biophys Res Commun
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2004
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0.78
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98
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Delayed reflection pressure wave: new aspects for postprandial hypotension.
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J Am Geriatr Soc
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2005
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0.77
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99
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Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population: The Nagahama Study.
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Medicine (Baltimore)
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2016
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0.77
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100
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Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy.
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J Cardiol
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2009
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0.77
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101
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Impact of synergistic polymorphisms in adrenergic receptor-related genes and cardiovascular events in patients with dilated cardiomyopathy.
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Circ J
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2012
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0.77
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102
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Association between fatty acid binding protein 3 gene variants and essential hypertension in humans.
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Am J Hypertens
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2008
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0.77
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103
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Association of the GNAS1 gene variant with hypertension is dependent on alcohol consumption.
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Hypertens Res
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2003
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0.77
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104
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Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese.
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Hypertens Res
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2005
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0.77
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105
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Association of a GNAS1 gene variant with hypertension and diabetes mellitus.
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Hypertens Res
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2004
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0.77
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106
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Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy.
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Int Heart J
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2015
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0.77
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107
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Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease.
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J Alzheimers Dis
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2012
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0.77
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108
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Postprandial hypertension, an overlooked risk marker for arteriosclerosis.
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Atherosclerosis
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2012
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0.77
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109
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Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice.
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J Hypertens
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2014
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0.76
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110
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The KSS 2011 reflects symptoms, physical activities, and radiographic grades in a Japanese population.
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Clin Orthop Relat Res
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2015
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0.76
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111
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Alcohol consumption is associated with decreased insulin resistance independent of body mass index in Japanese community-dwelling men.
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Tohoku J Exp Med
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2009
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0.76
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112
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A slightly high-normal glucose level is associated with increased arterial stiffness in Japanese community-dwelling persons with pre-diabetes.
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Vasc Med
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2013
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0.76
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113
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Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample: The Shigaraki Study.
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Hypertens Res
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2005
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0.76
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114
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An interaction between systolic blood pressure and angiotensin-converting enzyme gene polymorphism on carotid atherosclerosis.
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Hypertens Res
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2002
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115
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Genotype-specific association between circulating soluble cellular adhesion molecules and carotid intima-media thickness in community residents: J-SHIPP study. Shimanami Health Promoting Program.
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Hypertens Res
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2002
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0.76
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116
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Liver enzyme and adipocytokine profiles are synergistically associated with insulin resistance: the J-SHIPP study.
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J Atheroscler Thromb
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2012
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117
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Resistin, glomerular filtration rate, and insulin resistance.
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Hypertension
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2007
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118
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Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor, the decorin gene, in the general Japanese population.
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Diabetes
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2012
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[Anti-aging dock; the present situation and future perspectives].
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Nihon Ronen Igakkai Zasshi
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2011
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120
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Blood pressure, heart rate, and double product in a pooled cohort: the Japan Arteriosclerosis Longitudinal Study.
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J Hypertens
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2017
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121
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Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study).
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Int J Cardiol
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2008
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122
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A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.
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JCI Insight
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2017
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0.75
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123
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Change in arterial stiffness associated with monthly bisphosphonate treatment in women with postmenopausal osteoporosis.
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Menopause
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2014
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[Arterial aging as a risk for geriatric syndrome].
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Nihon Ronen Igakkai Zasshi
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2009
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125
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γ-Glutamyl transferase and high-molecular-weight adiponectin levels are synergistically associated with metabolic syndrome and insulin resistance in community-dwelling persons.
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Metab Syndr Relat Disord
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2011
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0.75
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126
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Associations between short one-leg standing time and speed of sound of calcaneal bone in a general population: the Shimanami Health Promoting Program (J-SHIPP) study.
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Geriatr Gerontol Int
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2010
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[Sarcopenia and visceral obesity: implications for postural instability in the elderly population].
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Nihon Ronen Igakkai Zasshi
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2011
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128
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Plasma resistin levels are associated with insulin resistance in older Japanese men from a rural village.
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Metab Syndr Relat Disord
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2012
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Atherosclerotic indices for the prediction of cognitive impairment in a middle-aged to elderly general population: shimanami health promoting program study.
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J Am Geriatr Soc
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2012
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130
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The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha.
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Clin Endocrinol (Oxf)
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2008
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131
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Association of retinal vessel calibers and longitudinal changes in arterial stiffness: the Nagahama study.
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J Hypertens
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2017
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132
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Genome-wide linkage disequilibrium mapping of hypertension in Japan.
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Hypertens Res
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2003
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Gene for medical cost?
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J Am Geriatr Soc
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2002
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0.75
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