L David Sibley

Author PubWeight™ 153.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008 4.16
2 Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity 2008 4.07
3 Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites. Mol Cell 2003 3.33
4 Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol 2010 2.83
5 Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J Exp Med 2005 2.76
6 Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids Res 2005 2.64
7 Cytoskeleton of apicomplexan parasites. Microbiol Mol Biol Rev 2002 2.61
8 Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe 2010 2.57
9 CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 2011 2.50
10 Calcium-dependent signaling and kinases in apicomplexan parasites. Cell Host Microbe 2009 2.46
11 Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. J Immunol 2004 2.35
12 A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis. J Leukoc Biol 2003 2.29
13 Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex. EMBO J 2003 2.26
14 Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature 2012 2.25
15 Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature 2010 2.25
16 Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol 2012 2.18
17 Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J Exp Med 2002 2.09
18 Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii. PLoS One 2010 2.08
19 Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A 2011 2.02
20 Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil. Emerg Infect Dis 2006 2.00
21 A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Proc Natl Acad Sci U S A 2005 1.99
22 Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii. J Cell Sci 2002 1.97
23 Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A 2006 1.95
24 Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii. Proc Natl Acad Sci U S A 2002 1.92
25 Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol 2010 1.91
26 Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America. Int J Parasitol 2011 1.88
27 Intracellular calcium stores in Toxoplasma gondii govern invasion of host cells. J Cell Sci 2003 1.87
28 Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature 2008 1.87
29 Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice. Infect Immun 2010 1.87
30 Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa. Mol Biol Evol 2006 1.83
31 Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol 2009 1.81
32 Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains. J Clin Microbiol 2005 1.78
33 Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database. Genome Res 2003 1.75
34 Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))/ryanodine-sensitive stores. J Biol Chem 2002 1.70
35 Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice. PLoS Genet 2009 1.66
36 Rhoptries: an arsenal of secreted virulence factors. Curr Opin Microbiol 2007 1.65
37 Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc Natl Acad Sci U S A 2012 1.64
38 Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole. Mol Microbiol 2010 1.61
39 Migration of Toxoplasma gondii across biological barriers. Trends Microbiol 2003 1.61
40 Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii. J Cell Sci 2002 1.54
41 Toxoplasma gondii strains defective in oral transmission are also defective in developmental stage differentiation. Infect Immun 2007 1.51
42 Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii. Mol Biol Cell 2005 1.50
43 Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. EMBO J 2009 1.50
44 A role for coccidian cGMP-dependent protein kinase in motility and invasion. Int J Parasitol 2004 1.48
45 Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii. PLoS Pathog 2010 1.48
46 Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cell Microbiol 2005 1.42
47 Distinct signalling pathways control Toxoplasma egress and host-cell invasion. EMBO J 2012 1.42
48 Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells. Cell Host Microbe 2009 1.39
49 Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii. J Cell Sci 2004 1.36
50 Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem 2008 1.35
51 Dinitroanilines bind alpha-tubulin to disrupt microtubules. Mol Biol Cell 2004 1.34
52 Molecular partitioning during host cell penetration by Toxoplasma gondii. Traffic 2004 1.34
53 The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18. PLoS Pathog 2012 1.34
54 Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog 2013 1.34
55 Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis. J Clin Microbiol 2006 1.31
56 ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites. Nucleic Acids Res 2004 1.30
57 Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii. Genome Res 2006 1.28
58 Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins. Mol Biol Cell 2002 1.28
59 Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii. Eukaryot Cell 2007 1.23
60 Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites. PLoS Pathog 2011 1.22
61 Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem 2013 1.19
62 C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells. J Biol Chem 2002 1.17
63 Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii. Eukaryot Cell 2009 1.15
64 Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites. Infect Immun 2005 1.13
65 The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival. J Biol Chem 2003 1.12
66 Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii. Biochem J 2005 1.10
67 A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii. MBio 2011 1.09
68 Monocytes mediate mucosal immunity to Toxoplasma gondii. Curr Opin Immunol 2010 1.09
69 Two separate, conserved acidic amino acid domains within the Toxoplasma gondii MIC2 cytoplasmic tail are required for parasite survival. J Biol Chem 2006 1.08
70 Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites. BMC Genomics 2005 1.08
71 Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion. Proc Natl Acad Sci U S A 2014 1.08
72 Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse. Proc Natl Acad Sci U S A 2014 1.07
73 Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin. J Biol Chem 2009 1.07
74 Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii. Mol Biol Cell 2011 1.07
75 High prevalence of unusual genotypes of Toxoplasma gondii infection in pork meat samples from Erechim, Southern Brazil. An Acad Bras Cienc 2007 1.06
76 Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model. Antimicrob Agents Chemother 2009 1.05
77 Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii. Eukaryot Cell 2008 1.02
78 The unusual dynamics of parasite actin result from isodesmic polymerization. Nat Commun 2013 1.01
79 The moving junction, a key portal to host cell invasion by apicomplexan parasites. Curr Opin Microbiol 2012 1.00
80 Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis. Antimicrob Agents Chemother 2007 1.00
81 Toxoplasma gondii merozoite gene expression analysis with comparison to the life cycle discloses a unique expression state during enteric development. BMC Genomics 2014 0.99
82 The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii. Cell Microbiol 2012 0.96
83 A novel actin-related protein is associated with daughter cell formation in Toxoplasma gondii. Eukaryot Cell 2008 0.91
84 Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates. ACS Chem Biol 2013 0.91
85 The secreted kinase ROP18 defends Toxoplasma's border. Bioessays 2011 0.91
86 Solution structure and dynamics of ADF from Toxoplasma gondii. J Struct Biol 2011 0.86
87 A human origin type II strain of Toxoplasma gondii causing severe encephalitis in mice. Microbes Infect 2006 0.86
88 Toxoplasma gondii profilin acts primarily to sequester G-actin while formins efficiently nucleate actin filament formation in vitro. Biochemistry 2012 0.86
89 Functional and biophysical analyses of the class XIV Toxoplasma gondii myosin D. J Muscle Res Cell Motil 2006 0.85
90 Sensitive and specific identification of Neospora caninum infection of cattle based on detection of serum antibodies to recombinant Ncp29. Clin Diagn Lab Immunol 2002 0.85
91 CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. J Exp Med 2014 0.84
92 Identification of small-molecule inhibitors of nucleoside triphosphate hydrolase in Toxoplasma gondii. Antimicrob Agents Chemother 2002 0.83
93 Actin-like protein 1 (ALP1) is a component of dynamic, high molecular weight complexes in Toxoplasma gondii. Cytoskeleton (Hoboken) 2010 0.83
94 Structural evidence for actin-like filaments in Toxoplasma gondii using high-resolution low-voltage field emission scanning electron microscopy. Microsc Microanal 2003 0.83
95 Total synthesis and configurational assignment of chondramide A. Chemistry 2010 0.81
96 Typing single-nucleotide polymorphisms in Toxoplasma gondii by allele-specific primer extension and microarray detection. Methods Mol Biol 2004 0.80
97 Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii. J Nat Prod 2013 0.79
98 No more free lunch. Nature 2002 0.79
99 Food- and waterborne pathogens: you are (infected by) what you eat! Microbes Infect 2004 0.78
100 Plants, endosymbionts and parasites: Abscisic acid and calcium signaling. Commun Integr Biol 2008 0.78
101 Expressed sequence tag (EST) analysis of Gregarine gametocyst development. Int J Parasitol 2004 0.77
102 Enhanced detection of multiply phosphorylated peptides and identification of their sites of modification. Anal Chem 2013 0.76
103 Crystallization and preliminary X-ray structural analysis of nucleoside triphosphate hydrolases from Neospora caninum and Toxoplasma gondii. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.76
104 Synthesis of chondramide A analogues with modified β-tyrosine and their biological evaluation. Chemistry 2011 0.76
105 Correction: Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii. PLoS Biol 2015 0.75