PubRank

Beth L Ostaszewski

Author PubWeight™ 25.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Dopamine covalently modifies and functionally inactivates parkin. Nat Med 2005 3.43
2 Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A 2003 3.36
3 Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 2009 2.38
4 Purification and characterization of the human gamma-secretase complex. Biochemistry 2004 2.18
5 Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A 2002 2.16
6 Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem 2003 1.83
7 Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry 2004 1.61
8 Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. J Neurosci 2011 1.53
9 gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. J Biol Chem 2005 1.45
10 Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry 2003 1.42
11 Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem 2002 1.06
12 Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry 2014 1.00
13 The effects of oxidative stress on parkin and other E3 ligases. J Neurochem 2007 0.97
14 Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem 2010 0.88
15 Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol 2002 0.86