PubRank

Chuan-En Wang

Author PubWeight™ 22.84‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 2005 2.57
2 N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci 2008 2.18
3 Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A 2009 1.87
4 Polyglutamine expansion of huntingtin impairs its nuclear export. Nat Genet 2005 1.62
5 Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. J Cell Biol 2008 1.51
6 Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J Neurosci 2008 1.41
7 Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum Mol Genet 2010 1.33
8 Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem 2010 1.25
9 Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development. Brain Res Dev Brain Res 2004 1.20
10 Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 2008 1.19
11 Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Hum Mol Genet 2010 1.08
12 Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity. J Biol Chem 2008 0.98
13 Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Hum Mol Genet 2011 0.96
14 Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proc Natl Acad Sci U S A 2014 0.91
15 Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J Cell Biol 2013 0.86
16 Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J Neurosci 2013 0.82
17 Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cell Mol Life Sci 2011 0.79
18 TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain. Hum Mol Genet 2013 0.76