Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans.

PubWeight™: 0.94‹?›

🔗 View Article (PMC 2875531)

Published in Crit Care on February 11, 2010

Authors

Ronan Mg Berg1, Sarah Taudorf, Damian M Bailey, Carsten Lundby, Fin Stolze Larsen, Bente Klarlund Pedersen, Kirsten Møller

Author Affiliations

1: Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. ronan@dadlnet.dk

Articles cited by this

Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem (1987) 2.09

Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med (1990) 2.04

Human endotoxemia as a model of systemic inflammation. Curr Med Chem (2008) 1.89

Evidence of inter-organ amino-acid transport by blood cells in humans. Proc Natl Acad Sci U S A (1973) 1.60

Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure. Gastroenterology (2001) 1.60

Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital. J Hepatol (2007) 1.52

Structure of the blood-brain barrier and its role in the transport of amino acids. J Nutr (2006) 1.50

The role of plasma amino acids in hepatic encephalopathy. Surgery (1975) 1.49

Pathophysiology of septic encephalopathy: a review. Crit Care Med (2000) 1.46

Plasma amino acids as predictors of the severity and outcome of sepsis. Ann Surg (1979) 1.31

Amino acid derangements in patients with sepsis: treatment with branched chain amino acid rich infusions. Ann Surg (1978) 1.29

Human models of low-grade inflammation: bolus versus continuous infusion of endotoxin. Clin Vaccine Immunol (2007) 1.22

The neurological complications of sepsis. Ann Neurol (1993) 1.15

Brain amino acid requirements and toxicity: the example of leucine. J Nutr (2005) 1.14

The encephalopathy associated with septic illness. Clin Invest Med (1990) 1.07

Longitudinal changes of biochemical parameters in muscle during critical illness. Metabolism (1997) 1.05

Plasma-amino acid profiles in sepsis and stress. Ann Surg (1989) 1.03

Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology (2007) 1.03

Blood-brain barrier transport of amino acids in healthy controls and in patients with phenylketonuria. J Inherit Metab Dis (1995) 1.00

Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries. J Biol Chem (1986) 0.99

Identifying the direct effects of ammonia on the brain. Metab Brain Dis (2008) 0.98

Longitudinal pattern of glutamine/glutamate balance across the leg in long-stay intensive care unit patients. Clin Nutr (2002) 0.98

Blood-brain barrier permeability to ammonia in liver failure: a critical reappraisal. Neurochem Int (2004) 0.97

Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier. Am J Physiol Endocrinol Metab (2003) 0.95

Blood-brain barrier derangement in sepsis: cause of septic encephalopathy? Am J Surg (1981) 0.93

Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. Crit Care (2009) 0.89

Parenteral administration of different amounts of branch-chain amino acids in septic patients: clinical and metabolic aspects. Crit Care Med (1997) 0.88

An alteration in the gamma-aminobutyric acid receptor system in experimentally induced septic shock in rats. Crit Care Med (1996) 0.88

The distribution of amino acids between plasma and erythrocytes. Clin Chim Acta (1980) 0.87

Amino acid imbalance early in septic encephalopathy. Intensive Care Med (2002) 0.87

The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia. Crit Care (2009) 0.87

Studies on the origin and significance of blood ammonia. II. The distribution of ammonia in whole blood, plasma and erythrocytes of man. Yale J Biol Med (1966) 0.86

Septic encephalopathy. Evidence for altered phenylalanine metabolism and comparison with hepatic encephalopathy. Arch Intern Med (1990) 0.84

Net amino acid transport between plasma and erythrocytes and perfused dog brain. Am J Physiol (1977) 0.84

Brain neurotransmitter profile is deranged during sepsis and septic encephalopathy in the rat. J Surg Res (1985) 0.83

Cerebral blood flow and oxygen metabolism measured with the Kety-Schmidt method using nitrous oxide. Acta Anaesthesiol Scand (2008) 0.83

Asymmetrical transport of amino acids across the blood-brain barrier in humans. J Cereb Blood Flow Metab (1990) 0.80

Controversies in ammonia metabolism: implications for hepatic encephalopathy. Metab Brain Dis (2007) 0.80

Effect of branched chain amino acid enrichment of total parenteral nutrition on nitrogen sparing and clinical outcome of sepsis and trauma: a prospective randomized double blind trial. Br J Surg (1990) 0.78

Regional brain amino acid and neurotransmitter derangements during abdominal sepsis and septic encephalopathy in the rat. The effect of amino acid infusions. Arch Surg (1986) 0.78

Quantification of physiological amino acids by gradient ion-exchange high-performance liquid chromatography. J Chromatogr (1993) 0.77

Elevated cerebrospinal fluid glutamine in septic encephalopathy. J Clin Gastroenterol (1989) 0.77

Articles by these authors

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05

The anti-inflammatory effect of exercise. J Appl Physiol (1985) (2005) 6.87

"Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study. J Appl Physiol (1985) (2011) 4.80

Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab (2003) 2.90

Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am (2003) 2.73

Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep (2012) 2.66

Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J (2002) 2.66

IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab (2003) 2.59

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab (2013) 2.54

Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J (2003) 2.31

Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. Hepatology (2007) 2.28

Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrine. Anesthesiology (2012) 2.24

The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function. Exp Physiol (2012) 2.20

Retracted Exercise induces interleukin-8 expression in human skeletal muscle. J Physiol (2004) 2.09

Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm (2009) 2.09

Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial. Hepatology (2013) 2.08

[A scientific evaluation of the "alternative" food pyramid]. Ugeskr Laeger (2005) 2.04

Effect of transcutaneous electrical muscle stimulation on muscle volume in patients with septic shock. Crit Care Med (2011) 1.72

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun (2012) 1.72

Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood (2009) 1.66

Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med (2006) 1.66

Air to muscle O2 delivery during exercise at altitude. High Alt Med Biol (2009) 1.59

Low-dose endotoxemia and human neuropsychological functions. Brain Behav Immun (2005) 1.53

Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital. J Hepatol (2007) 1.52

The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15. Appl Physiol Nutr Metab (2007) 1.51

Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia. Diabetes (2009) 1.51

Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV. PLoS One (2013) 1.50

Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med (2003) 1.49

Screening for recombinant human erythropoietin using [Hb], reticulocytes, the OFF(hr score), OFF(z score) and Hb(z score): status of the Blood Passport. Eur J Appl Physiol (2010) 1.48

Laboratory indicators of the diagnosis and course of imported malaria. Scand J Infect Dis (2007) 1.47

Acute mountain sickness: controversies and advances. High Alt Med Biol (2004) 1.46

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans. J Physiol (2002) 1.45

Dynamics of the skeletal muscle secretome during myoblast differentiation. Mol Cell Proteomics (2010) 1.44

Erythropoietin over-expression protects against diet-induced obesity in mice through increased fat oxidation in muscles. PLoS One (2009) 1.44

IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.43

Biomechanical and nonfunctional assessment of physical capacity in male ICU survivors. Crit Care Med (2013) 1.42

Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 m. High Alt Med Biol (2011) 1.41

Asymptomatic bacteriuria in elderly humans is associated with increased levels of circulating TNF receptors and elevated numbers of neutrophils. Exp Gerontol (2002) 1.39

Retracted Interleukin-6 receptor expression in contracting human skeletal muscle: regulating role of IL-6. FASEB J (2005) 1.39

Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol (1985) (2002) 1.38

Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab (2004) 1.38

Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice. Proc Natl Acad Sci U S A (2009) 1.37

MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology (2007) 1.37

Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes. J Appl Physiol (1985) (2012) 1.37

Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. J Physiol (2007) 1.34

Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness. J Cereb Blood Flow Metab (2006) 1.34

Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass. J Clin Endocrinol Metab (2008) 1.24

Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men. Am J Physiol Heart Circ Physiol (2009) 1.24

Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. J Leukoc Biol (2010) 1.23

Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol (2002) 1.22

Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans. Am J Physiol Endocrinol Metab (2006) 1.22

Cerebral ammonia uptake and accumulation during prolonged exercise in humans. J Physiol (2004) 1.22

Exercise-induced brachial artery vasodilation: role of free radicals. Am J Physiol Heart Circ Physiol (2006) 1.21

High plasma levels of intact and cleaved soluble urokinase receptor reflect immune activation and are independent predictors of mortality in HIV-1-infected patients. J Acquir Immune Defic Syndr (2005) 1.21

Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle. J Physiol (2002) 1.20

Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Clin Sci (Lond) (2009) 1.19

Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab (2007) 1.19

Endurance Training and V˙O2max: Role of Maximal Cardiac Output and Oxygen Extraction. Med Sci Sports Exerc (2015) 1.17

Interleukin-6 release from the human brain during prolonged exercise. J Physiol (2002) 1.17

Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr (2010) 1.16

Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness? Am J Physiol Regul Integr Comp Physiol (2009) 1.16

Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl (2003) 1.14

Plasma YKL-40: a BMI-independent marker of type 2 diabetes. Diabetes (2008) 1.14

High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability. J Physiol (2010) 1.14

Enhanced Performance after Repeated Sprint Training in Hypoxia: False or Reality? Med Sci Sports Exerc (2015) 1.13

Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function. J Appl Physiol (1985) (2013) 1.13

The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol (2003) 1.12

Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle. J Appl Physiol (1985) (2005) 1.12

The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletes. Br J Sports Med (2012) 1.12

Retracted Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise. FASEB J (2003) 1.12

Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite. Am J Physiol Heart Circ Physiol (2009) 1.11

Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis: a prospective study. J Crit Care (2013) 1.11

Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function. J Physiol (2008) 1.11

Glucose ingestion during endurance training does not alter adaptation. J Appl Physiol (1985) (2009) 1.10

The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia. Eur J Appl Physiol (2009) 1.09

Prolonged exercise, lymphocyte apoptosis and F2-isoprostanes. Eur J Appl Physiol (2002) 1.07

Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. J Am Geriatr Soc (2004) 1.06

During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level. J Physiol (2007) 1.06

Therapeutic hypothermia for acute liver failure. Crit Care Med (2009) 1.05

Skeletal muscle adaptation: training twice every second day vs. training once daily. J Appl Physiol (1985) (2004) 1.05

Skiing across the Greenland icecap: divergent effects on limb muscle adaptations and substrate oxidation. J Exp Biol (2003) 1.04

Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals. J Clin Endocrinol Metab (2008) 1.04

Calprotectin is released from human skeletal muscle tissue during exercise. J Physiol (2008) 1.03

Neuro-oxidative-nitrosative stress in sepsis. J Cereb Blood Flow Metab (2011) 1.01

Importance of hemoglobin concentration to exercise: acute manipulations. Respir Physiol Neurobiol (2006) 1.01

Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. Proteomics (2008) 1.01

Type 2 diabetes is associated with altered NF-κB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS. PLoS One (2011) 1.00

Calprotectin--a novel marker of obesity. PLoS One (2009) 1.00

Skeletal muscle as an immunogenic organ. Curr Opin Pharmacol (2008) 1.00

Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissue. Am J Physiol Endocrinol Metab (2003) 1.00