| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
|
J Med Chem
|
2006
|
2.09
|
|
2
|
Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients.
|
Int J Cancer
|
2009
|
1.53
|
|
3
|
Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells.
|
Br J Pharmacol
|
2011
|
1.10
|
|
4
|
Aromatic-carbohydrate interactions: an NMR and computational study of model systems.
|
Chemistry
|
2008
|
1.06
|
|
5
|
A compound belonging to traditional Chinese medicine improves nocturnal activity in Parkinson's disease.
|
Sleep Med
|
2011
|
0.91
|
|
6
|
Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.
|
J Am Chem Soc
|
2003
|
0.88
|
|
7
|
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
|
Bioorg Med Chem
|
2010
|
0.86
|
|
8
|
Factors affecting operating time in laparoscopic anterior resection of rectal cancer.
|
World J Surg Oncol
|
2014
|
0.85
|
|
9
|
Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell-cell contact inhibits proliferation of hepatic stellate cells.
|
Life Sci
|
2011
|
0.85
|
|
10
|
NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats.
|
Am J Physiol Cell Physiol
|
2011
|
0.85
|
|
11
|
Aporphine alkaloids from the roots of Stephania viridiflavens.
|
Nat Prod Res
|
2010
|
0.84
|
|
12
|
Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.
|
J Med Chem
|
2009
|
0.83
|
|
13
|
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
|
J Med Chem
|
2006
|
0.82
|
|
14
|
Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.
|
J Med Chem
|
2009
|
0.80
|
|
15
|
Vulgarisin A, a new diterpenoid with a rare 5/6/4/5 ring skeleton from the Chinese medicinal plant Prunella vulgaris.
|
Org Lett
|
2014
|
0.79
|
|
16
|
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
|
Bioorg Med Chem Lett
|
2010
|
0.78
|
|
17
|
Synthesis and biological evaluation of Matijing-Su derivatives as potent anti-HBV agents.
|
Bioorg Med Chem
|
2011
|
0.77
|
|
18
|
[Long-term curative effects of suture plus proximal gastric vagotomy or triad-therapy for duodenal ulcer with acute perforation].
|
Zhonghua Wai Ke Za Zhi
|
2002
|
0.75
|
|
19
|
A novel base-induced isomerization gives access to unprecedented (E)-exo-glycals.
|
Chemistry
|
2013
|
0.75
|
|
20
|
[Postoperative pathological staging correlates the prognosis of rectal cancer after neoadjuvant chemoradiotherapy].
|
Zhonghua Wai Ke Za Zhi
|
2014
|
0.75
|
|
21
|
[Idiopathic retroperitoneal fibrosis: a clinical analysis of 7 cases].
|
Zhonghua Yi Xue Za Zhi
|
2002
|
0.75
|
|
22
|
Synthesis and anti-hepatitis B virus activities of Matijing-Su derivatives.
|
Bioorg Med Chem
|
2009
|
0.75
|
|
23
|
Selectfluor and NFSI exo-glycal fluorination strategies applied to the enhancement of the binding affinity of galactofuranosyltransferase GlfT2 inhibitors.
|
Chemistry
|
2014
|
0.75
|
|
24
|
A novel iridoid from Torricellia angulata var intermedia.
|
Nat Prod Res
|
2009
|
0.75
|
|
25
|
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
|
Bioorg Med Chem Lett
|
2010
|
0.75
|
|
26
|
Pyruvate kinase coupled glycosyltransferase assays: limitations, struggles and problems resolutions.
|
Chembiochem
|
2017
|
0.75
|
|
27
|
Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry.
|
Chem Commun (Camb)
|
2017
|
0.75
|
|
28
|
β-Stereoselective phosphorylations applied to the synthesis of ADP- and polyprenyl-β-mannopyranosides.
|
Org Lett
|
2014
|
0.75
|