Published in J Med Chem on March 11, 2010
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. BMC Biochem (2010) 0.90
Three functional β-carbonic anhydrases in Pseudomonas aeruginosa PAO1: role in survival in ambient air. Microbiology (2013) 0.90
The small protein CydX is required for function of cytochrome bd oxidase in Brucella abortus. Front Cell Infect Microbiol (2012) 0.90
Bacterial carbonic anhydrases as drug targets: toward novel antibiotics? Front Pharmacol (2011) 0.88
Nontypeable Haemophilus influenzae carbonic anhydrase is important for environmental and intracellular survival. J Bacteriol (2013) 0.84
Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans. Parasit Vectors (2014) 0.84
Biochemistry and physiology of the β class carbonic anhydrase (Cpb) from Clostridium perfringens strain 13. J Bacteriol (2013) 0.78
Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3. Acta Crystallogr F Struct Biol Commun (2016) 0.76
Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis. Parasit Vectors (2015) 0.76
Legionella pneumophila Carbonic Anhydrases: Underexplored Antibacterial Drug Targets. Pathogens (2016) 0.75
Exploring the Molecular Basis for Binding of Inhibitors by Threonyl-tRNA Synthetase from Brucella abortus: A Virtual Screening Study. Int J Mol Sci (2016) 0.75
Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors. Biomed Res Int (2014) 0.75
Synthesis and anticancer activity of thiosubstituted purines. Med Chem Res (2015) 0.75
Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal. J Gastroenterol (2006) 3.04
Anticancer and antiviral sulfonamides. Curr Med Chem (2003) 2.75
The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proc Natl Acad Sci U S A (2002) 2.57
The Brucella suis virB operon is induced intracellularly in macrophages. Proc Natl Acad Sci U S A (2002) 2.52
Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov (2011) 2.45
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett (2004) 2.33
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents. Med Res Rev (2003) 2.33
Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis. J Gastroenterol (2008) 2.31
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett (2005) 2.24
Japanese clinical guidelines for autoimmune pancreatitis. Pancreas (2009) 2.11
Carbonic anhydrase inhibitors. Med Res Rev (2003) 2.09
Synthesis and antimalarial activity of novel chiral and achiral benzenesulfonamides bearing 1, 3, 4-oxadiazole moieties. J Enzyme Inhib Med Chem (2007) 2.00
Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget (2012) 1.77
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res (2011) 1.76
Oxovanadium(IV) complexes of hydrazides: potential antifungal agents. J Enzyme Inhib Med Chem (2006) 1.73
Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J Enzyme Inhib Med Chem (2004) 1.72
Carbonic anhydrase in the scleractinian coral Stylophora pistillata: characterization, localization, and role in biomineralization. J Biol Chem (2008) 1.70
Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome-lysosome fusion in murine macrophages. Infect Immun (2003) 1.68
The new species Brucella microti replicates in macrophages and causes death in murine models of infection. J Infect Dis (2010) 1.60
Type IV secretion and Brucella virulence. Vet Microbiol (2002) 1.58
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J Med Chem (2004) 1.57
The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. J Biol Chem (2009) 1.53
Isatin-derived antibacterial and antifungal compounds and their transition metal complexes. J Enzyme Inhib Med Chem (2004) 1.52
Carbonic anhydrases as targets for medicinal chemistry. Bioorg Med Chem (2007) 1.45
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? Chem Rev (2012) 1.43
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc Natl Acad Sci U S A (2009) 1.43
Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome. Curr Pharm Des (2005) 1.43
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett (2004) 1.42
Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease. J Med Chem (2013) 1.42
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. J Biol Chem (2008) 1.42
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. J Biol Chem (2008) 1.40
The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB. Cell Microbiol (2006) 1.39
Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells. Cell Cycle (2013) 1.34
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett (2003) 1.32
Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors. Curr Med Chem (2007) 1.30
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. Eur J Med Chem (2010) 1.30
Anticonvulsant sulfonamides/sulfamates/sulfamides with carbonic anhydrase inhibitory activity: drug design and mechanism of action. Curr Pharm Des (2008) 1.29
Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol Sci (2006) 1.27
Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis. J Gastroenterol (2014) 1.26
Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase. J Biol Inorg Chem (2009) 1.26
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. Bioorg Med Chem Lett (2005) 1.26
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX. Bioorg Med Chem Lett (2005) 1.25
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem (2006) 1.25
Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II), Cu(II), Ni(II), and Zn(II) Complexes With Amino Acid-Derived Compounds. Bioinorg Chem Appl (2006) 1.21
Nationwide epidemiological survey of autoimmune pancreatitis in Japan. Pancreas (2012) 1.20
Sulfonamides and sulfonylated derivatives as anticancer agents. Curr Cancer Drug Targets (2002) 1.19
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J Biol Chem (2003) 1.19
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. Chem Commun (Camb) (2006) 1.19
A new coral carbonic anhydrase in Stylophora pistillata. Mar Biotechnol (NY) (2011) 1.18
Is a universal model of organic acidity possible: comparison of the acid/base properties of dissolved organic carbon in the boreal and temperate zones. Environ Sci Technol (2003) 1.17
Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa. J Physiol (2006) 1.17
Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Biochemistry (2003) 1.17
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem (2010) 1.16
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiother Oncol (2011) 1.15
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J Am Chem Soc (2009) 1.13
Root effect hemoglobin may have evolved to enhance general tissue oxygen delivery. Science (2013) 1.13
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem (2011) 1.13
Sulfamates and their therapeutic potential. Med Res Rev (2005) 1.12
In vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes. J Enzyme Inhib Med Chem (2006) 1.11
Bacterial protease inhibitors. Med Res Rev (2002) 1.10
Zinc complexes of benzothiazole-derived Schiff bases with antibacterial activity. J Enzyme Inhib Med Chem (2003) 1.10
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. Med Res Rev (2008) 1.09
New strategies for targeting the hypoxic tumour microenvironment in breast cancer. Cancer Treat Rev (2012) 1.08
The intramacrophagic environment of Brucella suis and bacterial response. Vet Microbiol (2002) 1.08