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1
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The tuberous sclerosis complex.
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N Engl J Med
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2006
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13.53
|
|
2
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Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
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Proc Natl Acad Sci U S A
|
2011
|
2.73
|
|
3
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Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.
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Am J Respir Crit Care Med
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2002
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2.56
|
|
4
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Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways.
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Am J Physiol Lung Cell Mol Physiol
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2003
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2.54
|
|
5
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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.
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EMBO J
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2007
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2.27
|
|
6
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Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
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J Biol Chem
|
2004
|
1.75
|
|
7
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Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures.
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Am J Pathol
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2003
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1.57
|
|
8
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Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
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J Biol Chem
|
2006
|
1.36
|
|
9
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The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
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J Biol Chem
|
2007
|
1.34
|
|
10
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Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.
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J Biol Chem
|
2004
|
1.28
|
|
11
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The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.
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J Clin Invest
|
2009
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1.17
|
|
12
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Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
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EMBO Mol Med
|
2011
|
1.07
|
|
13
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mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis.
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Lymphat Res Biol
|
2010
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1.05
|
|
14
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Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy.
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Proc Am Thorac Soc
|
2010
|
0.99
|
|
15
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Analysis of published PKD1 gene sequence variants.
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Nat Genet
|
2007
|
0.98
|
|
16
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Autophagy: an 'Achilles' heel of tumorigenesis in TSC and LAM.
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Autophagy
|
2011
|
0.97
|
|
17
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Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
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J Exp Med
|
2014
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0.97
|
|
18
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Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.
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J Biol Chem
|
2003
|
0.95
|
|
19
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Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.
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Proc Natl Acad Sci U S A
|
2013
|
0.92
|
|
20
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Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.
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Cancer Res
|
2006
|
0.88
|
|
21
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The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?
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Ann N Y Acad Sci
|
2005
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0.85
|
|
22
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Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.
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Hum Mol Genet
|
2005
|
0.84
|
|
23
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Mutational analysis of the von hippel lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients.
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Mod Pathol
|
2002
|
0.80
|
|
24
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Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.
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J Child Neurol
|
2004
|
0.77
|
|
25
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TORC1 activation and autophagy inhibition: opposing forces in Rheb-driven tumorigenesis.
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Cell Cycle
|
2011
|
0.76
|
|
26
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Mutation detection in tumor suppressor genes using archival tissue specimens.
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Methods Mol Med
|
2006
|
0.75
|