PubRank

Zeger Debyser

Author PubWeight™ 168.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J Biol Chem 2002 4.91
2 LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J Biol Chem 2003 3.97
3 Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum Gene Ther 2007 2.64
4 Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. Hum Gene Ther 2010 2.51
5 Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat Chem Biol 2010 2.48
6 Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication. J Biol Chem 2005 2.44
7 Transportin-SR2 imports HIV into the nucleus. Curr Biol 2008 2.35
8 The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. J Biol Chem 2005 2.28
9 Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J Virol 2006 2.09
10 Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy. J Gene Med 2013 2.02
11 Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication. J Virol 2006 1.82
12 LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Mol Ther 2010 1.72
13 Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction. J Am Coll Cardiol 2010 1.70
14 Cellular co-factors of HIV-1 integration. Trends Biochem Sci 2006 1.68
15 Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction. J Virol 2003 1.61
16 Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. Hum Gene Ther 2009 1.54
17 Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations. J Virol 2003 1.54
18 Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Hum Gene Ther 2002 1.50
19 Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. J Biol Chem 2004 1.47
20 Comparison of lentiviral vector titration methods. BMC Biotechnol 2006 1.42
21 Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. PLoS Pathog 2007 1.41
22 Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization. Antimicrob Agents Chemother 2012 1.40
23 Upscaling of lentiviral vector production by tangential flow filtration. J Gene Med 2005 1.38
24 Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem 2008 1.33
25 Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ. J Biol Chem 2009 1.30
26 Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS 2004 1.28
27 The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites. Cell Rep 2013 1.26
28 LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. PLoS Pathog 2012 1.25
29 Identification of the LEDGF/p75 binding site in HIV-1 integrase. J Mol Biol 2006 1.24
30 Lentiviral nuclear import: a complex interplay between virus and host. Bioessays 2007 1.22
31 LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions. Retrovirology 2013 1.17
32 Interplay between HIV entry and transportin-SR2 dependency. Retrovirology 2011 1.17
33 Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. Bioorg Med Chem Lett 2007 1.16
34 Fetal surgery is a clinical reality. Semin Fetal Neonatal Med 2009 1.15
35 Novel targets for HIV therapy. Antiviral Res 2008 1.15
36 Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75. J Mol Biol 2007 1.14
37 New class of HIV integrase inhibitors that block viral replication in cell culture. Curr Biol 2002 1.13
38 Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Mol Ther 2006 1.11
39 Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function. J Med Chem 2011 1.11
40 Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. Hum Gene Ther 2003 1.11
41 Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci 2011 1.11
42 Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J Med Chem 2012 1.10
43 The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy. Virology 2013 1.10
44 Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain. Neuroimage 2012 1.10
45 Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Antimicrob Agents Chemother 2008 1.10
46 High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region. Nucleic Acids Res 2010 1.08
47 The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering. Nucleic Acids Res 2010 1.08
48 HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. AIDS Rev 2005 1.04
49 Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. J Med Chem 2005 1.04
50 Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Mol Cancer Res 2008 1.04
51 env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrob Agents Chemother 2002 1.04
52 Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting. J Biol Chem 2011 1.03
53 Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75. ChemMedChem 2009 1.01
54 Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrob Agents Chemother 2002 1.01
55 Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology. J Neurosci 2010 1.00
56 State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations. Curr Gene Ther 2009 1.00
57 Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain Pathol 2003 1.00
58 Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther 2006 1.00
59 Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75. FASEB J 2005 1.00
60 Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging. Stem Cells 2008 0.99
61 Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease. Mol Ther 2006 0.99
62 miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol 2011 0.99
63 Single-cell imaging of HIV-1 provirus (SCIP). Proc Natl Acad Sci U S A 2013 0.98
64 Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. AIDS 2011 0.97
65 Galectin-1 in melanoma biology and related neo-angiogenesis processes. J Invest Dermatol 2012 0.96
66 Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis. FEBS Lett 2008 0.95
67 Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). J Biol Chem 2012 0.94
68 Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions. J Med Chem 2009 0.94
69 In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75. J Mol Biol 2011 0.94
70 The remarkable conformational plasticity of alpha-synuclein: blessing or curse? Trends Mol Med 2013 0.94
71 HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. Retrovirology 2012 0.94
72 Immunohistochemical detection of transgene expression in the brain using small epitope tags. BMC Biotechnol 2010 0.93
73 Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis. Stem Cells 2006 0.93
74 Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors. J Biomol Screen 2012 0.93
75 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. Eur J Med Chem 2010 0.92
76 The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity. Mol Cancer Res 2012 0.90
77 The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication. Biochem Biophys Res Commun 2006 0.90
78 In search of small molecules blocking interactions between HIV proteins and intracellular cofactors. Mol Biosyst 2008 0.90
79 Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity. Virology 2008 0.90
80 Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells. Prostate 2011 0.89
81 Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. ChemMedChem 2011 0.89
82 Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication. Mol Ther 2012 0.89
83 The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. FASEB J 2006 0.88
84 Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Mol Ther 2012 0.88
85 DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy. J Biol Chem 2002 0.88
86 Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer. Nucl Med Biol 2011 0.87
87 Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS). J Fluoresc 2008 0.87
88 Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors. Biochem Biophys Res Commun 2005 0.87
89 A PET brain reporter gene system based on type 2 cannabinoid receptors. J Nucl Med 2011 0.87
90 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. ACS Chem Biol 2013 0.87
91 Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents. J Med Chem 2008 0.86
92 LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014). Expert Opin Ther Pat 2014 0.86
93 Discovery of small molecule HIV-1 integrase dimerization inhibitors. Bioorg Med Chem Lett 2012 0.86
94 Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2. Mol Ther 2010 0.86
95 Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography. Bioconjug Chem 2008 0.86
96 FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T. J Neurochem 2008 0.85
97 Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiol Aging 2006 0.85
98 Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model. Am J Obstet Gynecol 2007 0.85
99 Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors. Antimicrob Agents Chemother 2008 0.84
100 Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system. FASEB J 2012 0.84
101 Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. J Med Chem 2008 0.84
102 Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem 2008 0.84
103 Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity. Bioorg Med Chem Lett 2012 0.84
104 Simple criterion for selection of flavonoid compounds with anti-HIV activity. Bioorg Med Chem Lett 2006 0.84
105 N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. J Med Chem 2003 0.83
106 HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation. Eur J Med Chem 2010 0.83
107 Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1. Brain Struct Funct 2007 0.83
108 Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. Bioorg Med Chem 2011 0.83
109 Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD. Mol Ther Nucleic Acids 2013 0.83
110 Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor. Bioorg Med Chem 2010 0.83
111 A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series. Bioorg Med Chem Lett 2008 0.82
112 Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors. J Med Chem 2013 0.82
113 Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors. J Med Chem 2014 0.82
114 Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein. J Biol Chem 2012 0.82
115 Rilpivirine: a step forward in tailored HIV treatment. Lancet 2011 0.82
116 The total synthesis of fukiic acid, an HIV-1 integrase inhibitor. Eur J Med Chem 2007 0.82
117 Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation. J Biol Chem 2011 0.81
118 Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication. J Gene Med 2004 0.81
119 Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. Bioorg Med Chem Lett 2009 0.81
120 Cellular cofactors of lentiviral integrase: from target validation to drug discovery. Mol Biol Int 2012 0.81
121 Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration. Mol Neurobiol 2011 0.81
122 Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways. Hum Gene Ther 2014 0.81
123 Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging. Bioorg Med Chem 2009 0.80
124 Synthesis and antiviral properties of some polyphenols related to Salvia genus. Bioorg Med Chem Lett 2008 0.80
125 The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis. J Neurosci 2013 0.80
126 Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction. Bioorg Med Chem 2013 0.80
127 Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI. MAGMA 2010 0.80
128 4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process. Antiviral Res 2011 0.79
129 Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats. AIDS Rev 2005 0.79
130 HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology 2015 0.79
131 A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication. PLoS One 2012 0.79
132 Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. Nucl Med Biol 2012 0.78
133 Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem 2007 0.78
134 New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays. Eur J Med Chem 2013 0.78
135 Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. J Med Chem 2013 0.78
136 Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions. Bioorg Med Chem 2012 0.78
137 Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase. J Biol Chem 2013 0.78
138 Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes revealed by scanning force microscopy. Nanoscale 2014 0.78
139 New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors. Arch Pharm (Weinheim) 2007 0.78
140 Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. J Virol Methods 2003 0.77
141 A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors. ChemMedChem 2011 0.77
142 Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology. Antivir Chem Chemother 2005 0.77
143 HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme. ACS Nano 2014 0.77
144 Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells. Biochem Biophys Res Commun 2005 0.77
145 Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors. AIDS 2013 0.77
146 Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF. Expert Opin Pharmacother 2012 0.77
147 Seeing genes at work in the living brain with non-invasive molecular imaging. Curr Gene Ther 2009 0.77
148 Elvitegravir: a once daily alternative to raltegravir. Lancet Infect Dis 2011 0.77
149 A novel surgical approach for intratracheal administration of bioactive agents in a fetal mouse model. J Vis Exp 2012 0.77
150 Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor. J Pept Sci 2013 0.77
151 New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent. Bioorg Med Chem 2010 0.76
152 Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies. Bioorg Med Chem Lett 2007 0.76
153 Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors. J Enzyme Inhib Med Chem 2012 0.76
154 Bioluminescence imaging of therapy response does not correlate with FDG-PET response in a mouse model of Burkitt lymphoma. Am J Nucl Med Mol Imaging 2012 0.76
155 In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer. Future Med Chem 2009 0.75
156 Efficient 3D database screening for novel HIV-1 IN inhibitors. J Chem Inf Comput Sci 2004 0.75
157 Quad's in it for antiretroviral therapy? Lancet 2012 0.75
158 A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. J Med Chem 2007 0.75
159 Targeting the HIV integration process in antiviral therapy. J HIV Ther 2008 0.75
160 Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorg Med Chem Lett 2007 0.75
161 New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action. Bioorg Med Chem 2010 0.75
162 Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity. J Enzyme Inhib Med Chem 2012 0.75
163 Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection. Drug Discov Today Technol 2013 0.75
164 Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors. J Enzyme Inhib Med Chem 2013 0.75
165 Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors. J Chem Inf Model 2007 0.75
166 Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. J Chromatogr A 2007 0.75