PubRank

Rakez Kayed

Author PubWeight™ 108.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006 16.19
2 Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003 14.03
3 Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 2004 5.14
4 Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem 2005 4.23
5 Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. J Biol Chem 2007 3.42
6 Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling. J Biol Chem 2002 3.37
7 Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A 2004 2.32
8 Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology 2006 2.27
9 Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem 2012 1.79
10 Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep 2012 1.77
11 Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J 2012 1.70
12 Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener 2011 1.67
13 Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J Gen Physiol 2006 1.64
14 Preparation and characterization of neurotoxic tau oligomers. Biochemistry 2010 1.53
15 Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes 2007 1.52
16 Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A 2005 1.49
17 Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab 2006 1.47
18 Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry 2007 1.44
19 Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest 2006 1.43
20 Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci 2014 1.28
21 ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem 2006 1.28
22 Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. J Biol Chem 2011 1.24
23 Soluble and mature amyloid fibrils in drusen deposits. Invest Ophthalmol Vis Sci 2009 1.18
24 Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice. J Neurosci Res 2010 1.17
25 Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res 2005 1.16
26 Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Aging Cell 2008 1.15
27 Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proc Natl Acad Sci U S A 2007 1.12
28 Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest 2013 1.12
29 Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromolecular Med 2007 1.12
30 Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging 2006 1.10
31 Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate. PLoS One 2009 1.07
32 Formation and propagation of tau oligomeric seeds. Front Neurol 2013 1.04
33 Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci 2010 1.04
34 Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation 2005 1.03
35 Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem 2013 1.01
36 A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol 2009 0.98
37 α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem 2011 0.96
38 Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Mol Neurodegener 2008 0.93
39 Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener 2012 0.92
40 TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo. Hum Mol Genet 2013 0.92
41 LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein. J Lipid Res 2004 0.90
42 Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Res 2005 0.90
43 Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies. Exp Dermatol 2010 0.90
44 Tau aggregates as immunotherapeutic targets. Front Biosci (Schol Ed) 2013 0.89
45 Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. J Alzheimers Dis 2010 0.89
46 CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. J Exp Med 2008 0.88
47 Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration. J Alzheimers Dis 2010 0.87
48 Advances in therapeutics for neurodegenerative tauopathies: moving toward the specific targeting of the most toxic tau species. ACS Chem Neurosci 2014 0.87
49 Inhaled insulin forms toxic pulmonary amyloid aggregates. Endocrinology 2010 0.86
50 Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. J Mol Biol 2009 0.85
51 ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function. Int J Alzheimers Dis 2011 0.84
52 Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity. Biochem Biophys Res Commun 2012 0.83
53 Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine 2006 0.83
54 Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. Int J Alzheimers Dis 2009 0.82
55 Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains. FEBS Lett 2011 0.80
56 The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med 2002 0.80
57 Differential activation of the ER stress factor XBP1 by oligomeric assemblies. Neurochem Res 2012 0.80
58 Design of metastable β-sheet oligomers from natively unstructured peptide. ACS Chem Neurosci 2013 0.78
59 Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis. J Am Acad Dermatol 2011 0.77
60 Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis. Front Neurol 2012 0.76
61 Tau protein: function and pathology. Int J Alzheimers Dis 2012 0.76
62 New vaccine development for chronic brain disease. Neuropsychopharmacology 2010 0.76
63 Alzheimer's disease imaging with a novel Tau targeted near infrared ratiometric probe. Am J Nucl Med Mol Imaging 2013 0.75
64 Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity. Sci Rep 2017 0.75
65 Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation. Mol Cell Neurosci 2005 0.75