Receptor tyrosine kinase transmembrane domains: Function, dimer structure and dimerization energetics.

PubWeight™: 1.06‹?› | Rank: Top 15%

🔗 View Article (PMC 2900622)

Published in Cell Adh Migr on April 23, 2010

Authors

Edwin Li1, Kalina Hristova

Author Affiliations

1: Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.

Articles citing this

The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization. Sci Signal (2010) 1.22

Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry (2013) 1.07

Physical-chemical principles underlying RTK activation, and their implications for human disease. Biochim Biophys Acta (2011) 1.06

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases. Nat Rev Cancer (2012) 0.99

Physical basis behind achondroplasia, the most common form of human dwarfism. J Biol Chem (2010) 0.99

Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies. Structure (2013) 0.93

Leukemia and benzene. Int J Environ Res Public Health (2012) 0.93

Glycophorin A transmembrane domain dimerization in plasma membrane vesicles derived from CHO, HEK 293T, and A431 cells. Biochim Biophys Acta (2013) 0.92

Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain. Biochim Biophys Acta (2010) 0.91

FGFR3 heterodimerization in achondroplasia, the most common form of human dwarfism. J Biol Chem (2011) 0.91

Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells. BMC Biophys (2013) 0.90

Strong dimerization of wild-type ErbB2/Neu transmembrane domain and the oncogenic Val664Glu mutant in mammalian plasma membranes. Biochim Biophys Acta (2014) 0.85

The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. PLoS Genet (2014) 0.85

Robust driving forces for transmembrane helix packing. Biophys J (2012) 0.85

High-throughput selection of transmembrane sequences that enhance receptor tyrosine kinase activation. J Mol Biol (2011) 0.84

Multiple consequences of a single amino acid pathogenic RTK mutation: the A391E mutation in FGFR3. PLoS One (2013) 0.81

Tie2 and Eph receptor tyrosine kinase activation and signaling. Cold Spring Harb Perspect Biol (2014) 0.79

Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6. Biosci Rep (2015) 0.79

The SCHOOL of nature: III. From mechanistic understanding to novel therapies. Self Nonself (2010) 0.77

VEGFR-2 conformational switch in response to ligand binding. Elife (2016) 0.77

Understanding the FRET Signatures of Interacting Membrane Proteins. J Biol Chem (2017) 0.75

Articles cited by this

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28

Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev (2005) 9.62

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell (1986) 7.06

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature (1985) 6.23

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell (2002) 5.61

Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol (1994) 5.24

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27

Signalling by receptor tyrosine kinases. Annu Rev Biochem (1993) 4.11

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature (1989) 3.27

Common and distinct elements in cellular signaling via EGF and FGF receptors. Science (2004) 2.99

The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell (2009) 2.90

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol Cell (2004) 2.64

Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet (1995) 2.51

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J (1993) 2.46

ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol (2006) 2.39

The single transmembrane domains of ErbB receptors self-associate in cell membranes. J Biol Chem (2001) 2.25

Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc Natl Acad Sci U S A (2007) 2.20

Juxtamembrane autoinhibition in receptor tyrosine kinases. Nat Rev Mol Cell Biol (2004) 2.19

Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies. Biochemistry (2006) 1.96

A putative molecular-activation switch in the transmembrane domain of erbB2. Proc Natl Acad Sci U S A (2002) 1.86

Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator. J Mol Biol (1996) 1.86

Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state. J Biol Chem (2008) 1.81

Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environment. Anal Biochem (2005) 1.81

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp Cell Res (2004) 1.78

Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells (2005) 1.76

Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders. Eur J Hum Genet (2002) 1.72

The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding. J Biol Chem (2009) 1.64

A sequence motif in the transmembrane region of growth factor receptors with tyrosine kinase activity mediates dimerization. Protein Eng (1990) 1.62

FGFR3 dimer stabilization due to a single amino acid pathogenic mutation. J Mol Biol (2005) 1.59

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and forster resonance energy transfer suggest weak interactions between fibroblast growth factor receptor 3 (FGFR3) transmembrane domains in the absence of extracellular domains and ligands. Biochemistry (2005) 1.59

Strong hydrogen bonding interactions involving a buried glutamic acid in the transmembrane sequence of the neu/erbB-2 receptor. Nat Struct Biol (1996) 1.50

Dynamic helix interactions in transmembrane signaling. Cell (2006) 1.49

Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol Cell Biol (2000) 1.47

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A (2003) 1.44

Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. J Biol Chem (2008) 1.33

Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. J Biol Chem (1998) 1.31

Energetics of ErbB1 transmembrane domain dimerization in lipid bilayers. Biophys J (2009) 1.24

Signal transduction by several KIT juxtamembrane domain mutations. Oncogene (2003) 1.20

In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry (2009) 1.16

Pathogenic activation of receptor tyrosine kinases in mammalian membranes. J Mol Biol (2008) 1.15

FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation. FEBS Lett (2002) 1.14

Two motifs within a transmembrane domain, one for homodimerization and the other for heterodimerization. J Biol Chem (2004) 1.14

A dimerization hierarchy in the transmembrane domains of the HER receptor family. Biochemistry (2007) 1.11

Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR(622-660) and its interaction with Ca2+/calmodulin. Biochemistry (2006) 1.10

Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL. Protein Expr Purif (2009) 1.09

The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper. J Biol Chem (2003) 1.08

Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization. J Bone Miner Res (2002) 1.07

Transmembrane helix heterodimerization in lipid bilayers: probing the energetics behind autosomal dominant growth disorders. J Mol Biol (2006) 1.06

Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers. Biochemistry (2007) 1.05

Forster resonance energy transfer measurements of transmembrane helix dimerization energetics. Methods Enzymol (2008) 1.05

Transmembrane domain of EphA1 receptor forms dimers in membrane-like environment. Biochim Biophys Acta (2008) 1.04

Two GxxxG-like motifs facilitate promiscuous interactions of the human ErbB transmembrane domains. J Mol Biol (2009) 1.03

Transmembrane interactions in the activation of the Neu receptor tyrosine kinase. Biochemistry (2002) 1.02

Neutron diffraction studies of fluid bilayers with transmembrane proteins: structural consequences of the achondroplasia mutation. Biophys J (2006) 1.00

The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor. FEBS J (2007) 0.99

The transmembrane domains of ErbB receptors do not dimerize strongly in micelles. J Mol Biol (2005) 0.98

Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region. J Biol Chem (1999) 0.95

The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J Biol Chem (2004) 0.93

Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization. Biochim Biophys Acta (2009) 0.92

Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance. Cell Signal (2002) 0.87

Hill coefficient analysis of transmembrane helix dimerization. J Membr Biol (2009) 0.80

Articles by these authors

Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies. Biochemistry (2006) 1.96

MPEx: a tool for exploring membrane proteins. Protein Sci (2009) 1.89

Antimicrobial peptides: successes, challenges and unanswered questions. J Membr Biol (2011) 1.83

Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environment. Anal Biochem (2005) 1.81

FGFR3 dimer stabilization due to a single amino acid pathogenic mutation. J Mol Biol (2005) 1.59

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and forster resonance energy transfer suggest weak interactions between fibroblast growth factor receptor 3 (FGFR3) transmembrane domains in the absence of extracellular domains and ligands. Biochemistry (2005) 1.59

Measuring the energetics of membrane protein dimerization in mammalian membranes. J Am Chem Soc (2010) 1.45

Spontaneous membrane-translocating peptides by orthogonal high-throughput screening. J Am Chem Soc (2011) 1.35

The achondroplasia mutation does not alter the dimerization energetics of the fibroblast growth factor receptor 3 transmembrane domain. Biochemistry (2006) 1.28

Transmembrane helix dimerization: beyond the search for sequence motifs. Biochim Biophys Acta (2011) 1.26

Energetics of ErbB1 transmembrane domain dimerization in lipid bilayers. Biophys J (2009) 1.24

The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization. Sci Signal (2010) 1.22

Quantitative measurements of protein interactions in a crowded cellular environment. Anal Chem (2008) 1.21

Pathogenic activation of receptor tyrosine kinases in mammalian membranes. J Mol Biol (2008) 1.15

Studies of receptor tyrosine kinase transmembrane domain interactions: the EmEx-FRET method. J Membr Biol (2007) 1.13

Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL. Protein Expr Purif (2009) 1.09

Physical-chemical principles underlying RTK activation, and their implications for human disease. Biochim Biophys Acta (2011) 1.06

Transmembrane helix heterodimerization in lipid bilayers: probing the energetics behind autosomal dominant growth disorders. J Mol Biol (2006) 1.06

Synthesis and initial characterization of FGFR3 transmembrane domain: consequences of sequence modifications. Biochim Biophys Acta (2005) 1.06

Forster resonance energy transfer measurements of transmembrane helix dimerization energetics. Methods Enzymol (2008) 1.05

Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers. Biochemistry (2007) 1.05

Imaging forster resonance energy transfer measurements of transmembrane helix interactions in lipid bilayers on a solid support. Langmuir (2004) 1.05

Direct assessment of the effect of the Gly380Arg achondroplasia mutation on FGFR3 dimerization using quantitative imaging FRET. PLoS One (2012) 1.04

Directed assembly of surface-supported bilayers with transmembrane helices. Langmuir (2006) 1.02

Neutron diffraction studies of fluid bilayers with transmembrane proteins: structural consequences of the achondroplasia mutation. Biophys J (2006) 1.00

Physical basis behind achondroplasia, the most common form of human dwarfism. J Biol Chem (2010) 0.99

Production of plasma membrane vesicles with chloride salts and their utility as a cell membrane mimetic for biophysical characterization of membrane protein interactions. Anal Chem (2012) 0.99

A simple "proximity" correction for Förster resonance energy transfer efficiency determination in membranes using lifetime measurements. Anal Biochem (2008) 0.96

FGFR3 transmembrane domain interactions persist in the presence of its extracellular domain. Biophys J (2013) 0.95

Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies. Structure (2013) 0.93

Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization. Biochim Biophys Acta (2009) 0.92

The A391E mutation enhances FGFR3 activation in the absence of ligand. Biochim Biophys Acta (2011) 0.92

Glycophorin A transmembrane domain dimerization in plasma membrane vesicles derived from CHO, HEK 293T, and A431 cells. Biochim Biophys Acta (2013) 0.92

The physical basis of FGFR3 response to fgf1 and fgf2. Biochemistry (2011) 0.91

Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain. Biochim Biophys Acta (2010) 0.91

A membrane-translocating peptide penetrates into bilayers without significant bilayer perturbations. Biophys J (2013) 0.91

FGFR3 heterodimerization in achondroplasia, the most common form of human dwarfism. J Biol Chem (2011) 0.91

Characterization of antimicrobial peptide activity by electrochemical impedance spectroscopy. Biochim Biophys Acta (2008) 0.90

Assembly of the m2 tetramer is strongly modulated by lipid chain length. Biophys J (2010) 0.90

The electrical response of bilayers to the bee venom toxin melittin: evidence for transient bilayer permeabilization. Biochim Biophys Acta (2013) 0.88

Protein folding in membranes: insights from neutron diffraction studies of a membrane beta-sheet oligomer. Biophys J (2007) 0.88

Effect of a polymer cushion on the electrical properties and stability of surface-supported lipid bilayers. Langmuir (2010) 0.87

Surface-supported bilayers with transmembrane proteins: role of the polymer cushion revisited. Langmuir (2006) 0.87

A highly charged voltage-sensor helix spontaneously translocates across membranes. Angew Chem Int Ed Engl (2012) 0.87

Fully quantified spectral imaging reveals in vivo membrane protein interactions. Integr Biol (Camb) (2016) 0.86

On-the-resin N-terminal modification of long synthetic peptides. Anal Biochem (2012) 0.86

Electrical measurements of bilayer membranes formed by Langmuir-Blodgett deposition on single-crystal silicon. Langmuir (2007) 0.85

Interactions of membrane active peptides with planar supported bilayers: an impedance spectroscopy study. Langmuir (2012) 0.84

Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence. Sci Rep (2012) 0.84

High-throughput selection of transmembrane sequences that enhance receptor tyrosine kinase activation. J Mol Biol (2011) 0.84

Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide. J Am Chem Soc (2014) 0.84

Spectral Förster resonance energy transfer detection of protein interactions in surface-supported bilayers. Langmuir (2006) 0.83

Multiple consequences of a single amino acid pathogenic RTK mutation: the A391E mutation in FGFR3. PLoS One (2013) 0.81

Direct cytosolic delivery of polar cargo to cells by spontaneous membrane-translocating peptides. J Biol Chem (2013) 0.81

Hill coefficient analysis of transmembrane helix dimerization. J Membr Biol (2009) 0.80

Utility of surface-supported bilayers in studies of transmembrane helix dimerization. J Struct Biol (2009) 0.79

Bias-dependent admittance in hybrid bilayer membranes. Langmuir (2006) 0.78

Impedance spectroscopy of bilayer membranes on single crystal silicon. Biointerphases (2008) 0.78

Viewing the bilayer hydrocarbon core using neutron diffraction. J Membr Biol (2009) 0.78

Electrically addressable, biologically relevant surface-supported bilayers. Langmuir (2010) 0.77

Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines. Biotechnol Appl Biochem (2012) 0.76

Effect of the G375C and G346E achondroplasia mutations on FGFR3 activation. PLoS One (2012) 0.76

Surface supported bilayer platform for studies of lateral association of proteins in membranes (Mini Review). Biointerphases (2008) 0.76

Analysis of HIV-1 fusion peptide inhibition by synthetic peptides from E1 protein of GB virus C. J Colloid Interface Sci (2011) 0.76

Influence of applied potential on the impedance of alkanethiol SAMs. Langmuir (2007) 0.76

Quantification of the effects of mutations on receptor tyrosine kinase (RTK) activation in mammalian cells. Methods Mol Biol (2015) 0.75