| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
|
Nat Genet
|
2008
|
12.51
|
|
2
|
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis.
|
N Engl J Med
|
2005
|
6.83
|
|
3
|
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
|
Nat Genet
|
2008
|
3.71
|
|
4
|
Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study.
|
Ann Rheum Dis
|
2010
|
2.64
|
|
5
|
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.
|
Nat Genet
|
2011
|
2.54
|
|
6
|
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
|
Proc Natl Acad Sci U S A
|
2009
|
2.31
|
|
7
|
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.
|
J Clin Invest
|
2003
|
2.26
|
|
8
|
Vitamin D deficiency in systemic lupus erythematosus.
|
Autoimmun Rev
|
2005
|
2.25
|
|
9
|
The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture.
|
Arthritis Rheum
|
2008
|
2.13
|
|
10
|
Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus.
|
Arthritis Rheum
|
2010
|
1.98
|
|
11
|
Common variants within MECP2 confer risk of systemic lupus erythematosus.
|
PLoS One
|
2008
|
1.98
|
|
12
|
Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice.
|
J Immunol
|
2003
|
1.89
|
|
13
|
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
|
Nat Genet
|
2013
|
1.82
|
|
14
|
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
|
FASEB J
|
2008
|
1.71
|
|
15
|
Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype.
|
Arthritis Rheum
|
2005
|
1.58
|
|
16
|
A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.
|
Invest Ophthalmol Vis Sci
|
2009
|
1.54
|
|
17
|
Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience.
|
Cell Transplant
|
2013
|
1.53
|
|
18
|
Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus.
|
Clin Immunol
|
2012
|
1.53
|
|
19
|
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.
|
PLoS Genet
|
2011
|
1.49
|
|
20
|
Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.
|
Arthritis Rheum
|
2009
|
1.43
|
|
21
|
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.
|
Am J Hum Genet
|
2010
|
1.43
|
|
22
|
The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus.
|
PLoS One
|
2010
|
1.42
|
|
23
|
Lifetime exposure to trichloroethylene (TCE) does not accelerate autoimmune disease in MRL +/+ mice.
|
J Environ Sci Health A Tox Hazard Subst Environ Eng
|
2008
|
1.42
|
|
24
|
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.
|
Am J Hum Genet
|
2012
|
1.41
|
|
25
|
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.
|
Ann Rheum Dis
|
2011
|
1.41
|
|
26
|
Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid.
|
J Immunol
|
2004
|
1.40
|
|
27
|
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.
|
Ann Rheum Dis
|
2011
|
1.38
|
|
28
|
Role for Msh5 in the regulation of Ig class switch recombination.
|
Proc Natl Acad Sci U S A
|
2007
|
1.35
|
|
29
|
Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.
|
PLoS One
|
2008
|
1.31
|
|
30
|
Occupational risk factors for the development of systemic lupus erythematosus.
|
J Rheumatol
|
2004
|
1.31
|
|
31
|
Mechanisms of tissue injury in lupus nephritis.
|
Arthritis Res Ther
|
2011
|
1.31
|
|
32
|
Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage.
|
Invest Ophthalmol Vis Sci
|
2007
|
1.30
|
|
33
|
Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United States.
|
Arthritis Rheum
|
2002
|
1.29
|
|
34
|
Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
|
Ann Rheum Dis
|
2010
|
1.26
|
|
35
|
Autoantibody prevalence and lupus characteristics in a unique African American population.
|
Arthritis Rheum
|
2008
|
1.25
|
|
36
|
A polymorphism within IL21R confers risk for systemic lupus erythematosus.
|
Arthritis Rheum
|
2009
|
1.23
|
|
37
|
The lupus family registry and repository.
|
Rheumatology (Oxford)
|
2010
|
1.21
|
|
38
|
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.
|
Arthritis Rheum
|
2011
|
1.19
|
|
39
|
Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of patients with systemic lupus erythematosus and family members.
|
Arthritis Rheum
|
2012
|
1.19
|
|
40
|
The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice.
|
J Immunol
|
2008
|
1.16
|
|
41
|
Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
|
J Immunol
|
2010
|
1.16
|
|
42
|
Effects of complement factor D deficiency on the renal disease of MRL/lpr mice.
|
Kidney Int
|
2004
|
1.15
|
|
43
|
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.
|
PLoS Genet
|
2013
|
1.14
|
|
44
|
Hormonal and reproductive risk factors for development of systemic lupus erythematosus: results of a population-based, case-control study.
|
Arthritis Rheum
|
2002
|
1.14
|
|
45
|
Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells.
|
Arthritis Rheum
|
2006
|
1.14
|
|
46
|
Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate.
|
Toxicol Sci
|
2008
|
1.12
|
|
47
|
High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
|
Arthritis Rheum
|
2009
|
1.11
|
|
48
|
Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history.
|
J Clin Epidemiol
|
2002
|
1.10
|
|
49
|
The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy.
|
Am J Physiol Renal Physiol
|
2007
|
1.08
|
|
50
|
Sociodemographic associations with early disease damage in patients with systemic lupus erythematosus.
|
Arthritis Rheum
|
2007
|
1.08
|
|
51
|
The role of genetic variation near interferon-kappa in systemic lupus erythematosus.
|
J Biomed Biotechnol
|
2010
|
1.07
|
|
52
|
Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL/lpr mice.
|
J Immunol
|
2008
|
1.07
|
|
53
|
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.
|
Ann Rheum Dis
|
2012
|
1.07
|
|
54
|
Absence of functional alternative complement pathway alleviates lupus cerebritis.
|
Eur J Immunol
|
2007
|
1.06
|
|
55
|
Two aspects of the clinical and humanistic burden of systemic lupus erythematosus: mortality risk and quality of life early in the course of disease.
|
Arthritis Rheum
|
2008
|
1.06
|
|
56
|
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.
|
Ann Rheum Dis
|
2011
|
1.06
|
|
57
|
Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis.
|
Arthritis Rheum
|
2008
|
1.05
|
|
58
|
The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice.
|
J Autoimmun
|
2008
|
1.04
|
|
59
|
Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse.
|
Clin Immunol
|
2008
|
1.03
|
|
60
|
Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of systemic lupus erythematosus.
|
J Immunol
|
2006
|
1.01
|
|
61
|
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations.
|
Arthritis Rheum
|
2012
|
1.01
|
|
62
|
Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase.
|
Kidney Int
|
2002
|
1.01
|
|
63
|
Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.
|
J Rheumatol
|
2003
|
0.99
|
|
64
|
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.
|
Arthritis Rheum
|
2012
|
0.99
|
|
65
|
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.
|
PLoS Genet
|
2013
|
0.99
|
|
66
|
The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus.
|
Clin Immunol
|
2006
|
0.98
|
|
67
|
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.
|
Arthritis Rheum
|
2011
|
0.98
|
|
68
|
Enrichment of anti-glomerular antigen antibody-producing cells in the kidneys of MRL/MpJ-Fas(lpr) mice.
|
J Immunol
|
2004
|
0.98
|
|
69
|
Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice.
|
Eur J Immunol
|
2006
|
0.96
|
|
70
|
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.
|
Ann Rheum Dis
|
2012
|
0.96
|
|
71
|
A novel PPAR response element in the murine iNOS promoter.
|
Mol Immunol
|
2005
|
0.96
|
|
72
|
Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms.
|
Am J Pathol
|
2007
|
0.96
|
|
73
|
Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.
|
Arthritis Rheum
|
2012
|
0.96
|
|
74
|
ABIN1 dysfunction as a genetic basis for lupus nephritis.
|
J Am Soc Nephrol
|
2013
|
0.95
|
|
75
|
Ethnic disparities among patients with systemic lupus erythematosus in South Carolina.
|
J Rheumatol
|
2008
|
0.95
|
|
76
|
Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation.
|
Mol Immunol
|
2011
|
0.94
|
|
77
|
Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide.
|
J Pharmacol Exp Ther
|
2004
|
0.93
|
|
78
|
Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes.
|
Mol Immunol
|
2007
|
0.93
|
|
79
|
Use of genetic knockouts to modulate disease expression in a murine model of lupus, MRL/lpr mice.
|
Immunol Res
|
2002
|
0.92
|
|
80
|
Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism.
|
Hum Immunol
|
2004
|
0.92
|
|
81
|
PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.
|
PLoS One
|
2013
|
0.91
|
|
82
|
Mediators of injury in lupus nephritis.
|
Curr Opin Rheumatol
|
2002
|
0.91
|
|
83
|
The impact of systemic lupus erythematosus on employment.
|
J Rheumatol
|
2009
|
0.90
|
|
84
|
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.
|
PLoS Genet
|
2013
|
0.90
|
|
85
|
The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice.
|
Arthritis Rheum
|
2011
|
0.89
|
|
86
|
Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.
|
Arthritis Rheum
|
2011
|
0.89
|
|
87
|
Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.
|
PLoS Genet
|
2013
|
0.89
|
|
88
|
Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
|
Rheumatol Int
|
2012
|
0.88
|
|
89
|
Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene.
|
J Investig Med
|
2008
|
0.87
|
|
90
|
A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis.
|
Arthritis Res Ther
|
2010
|
0.87
|
|
91
|
Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunity.
|
J Rheumatol
|
2003
|
0.86
|
|
92
|
Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice.
|
Clin Immunol
|
2012
|
0.86
|
|
93
|
Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice.
|
Clin Immunol
|
2003
|
0.85
|
|
94
|
Nitric oxide induces apoptosis in spleen lymphocytes from MRL/lpr mice.
|
J Investig Med
|
2004
|
0.85
|
|
95
|
Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice.
|
J Immunol
|
2005
|
0.85
|
|
96
|
Evaluation of TRAF6 in a large multiancestral lupus cohort.
|
Arthritis Rheum
|
2012
|
0.84
|
|
97
|
Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus.
|
Clin Dev Immunol
|
2012
|
0.84
|
|
98
|
Inflammatory modulation of PPAR gamma expression and activity.
|
Clin Immunol
|
2005
|
0.83
|
|
99
|
Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort.
|
Autoimmune Dis
|
2012
|
0.83
|
|
100
|
The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition.
|
Mol Immunol
|
2011
|
0.82
|
|
101
|
Developmental immunotoxicity of trichloroethylene (TCE): studies in B6C3F1 mice.
|
J Environ Sci Health A Tox Hazard Subst Environ Eng
|
2006
|
0.82
|
|
102
|
A critical role of the transcription factor fli-1 in murine lupus development by regulation of interleukin-6 expression.
|
Arthritis Rheumatol
|
2014
|
0.82
|
|
103
|
Assessment of trichloroethylene (TCE) exposure in murine strains genetically-prone and non-prone to develop autoimmune disease.
|
J Environ Sci Health A Tox Hazard Subst Environ Eng
|
2009
|
0.81
|
|
104
|
Regulation of Fli1 gene expression and lupus.
|
Autoimmun Rev
|
2005
|
0.81
|
|
105
|
Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients.
|
Arthritis Rheum
|
2007
|
0.80
|
|
106
|
A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.
|
Adv Exp Med Biol
|
2010
|
0.80
|
|
107
|
In vitro evaluation of the effects of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on IL-2 production in human T-cells.
|
J Appl Toxicol
|
2014
|
0.79
|
|
108
|
Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.
|
J Rheumatol
|
2013
|
0.78
|
|
109
|
Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy.
|
Clin Rheumatol
|
2014
|
0.77
|
|
110
|
N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus.
|
J Rheumatol
|
2004
|
0.77
|
|
111
|
Estrogen Receptor Alpha Binding to ERE is Required for Full Tlr7- and Tlr9-Induced Inflammation.
|
SOJ Immunol
|
2014
|
0.77
|
|
112
|
Peroxisome proliferator-activated receptor gamma agonists: potential use for treating chronic inflammatory diseases.
|
Arthritis Rheum
|
2002
|
0.77
|
|
113
|
Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching".
|
J Immunol
|
2009
|
0.76
|
|
114
|
N,N,-diethyl-m-toluamide (DEET) suppresses humoral immunological function in B6C3F1 mice.
|
Toxicol Sci
|
2009
|
0.76
|
|
115
|
Estrogen receptor alpha modulates mesangial cell responses to toll-like receptor ligands.
|
Am J Med Sci
|
2014
|
0.76
|
|
116
|
Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis.
|
Am J Med Sci
|
2011
|
0.75
|
|
117
|
Impact of sphingosine kinase on inflammatory pathways in fibroblast-like synoviocytes.
|
Inflamm Allergy Drug Targets
|
2011
|
0.75
|