|
1
|
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.
|
Cancer Cell
|
2012
|
1.52
|
|
2
|
Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma.
|
Hepatology
|
2007
|
1.21
|
|
3
|
A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.
|
Cancer Res
|
2007
|
1.15
|
|
4
|
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor.
|
Mol Cancer Ther
|
2008
|
1.15
|
|
5
|
AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
|
Blood
|
2010
|
1.11
|
|
6
|
The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.
|
PLoS One
|
2010
|
1.11
|
|
7
|
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator.
|
J Biol Chem
|
2011
|
1.10
|
|
8
|
Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
|
Hepatology
|
2011
|
1.07
|
|
9
|
Development of novel adenosine monophosphate-activated protein kinase activators.
|
J Med Chem
|
2010
|
1.04
|
|
10
|
Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent.
|
Antimicrob Agents Chemother
|
2009
|
0.98
|
|
11
|
Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent.
|
J Biomed Sci
|
2009
|
0.97
|
|
12
|
Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors.
|
Cancer Res
|
2008
|
0.96
|
|
13
|
Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma.
|
Mol Pharmacol
|
2009
|
0.94
|
|
14
|
alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis.
|
Carcinogenesis
|
2009
|
0.93
|
|
15
|
OSU03012 activates Erk1/2 and Cdks leading to the accumulation of cells in the S-phase and apoptosis.
|
Int J Cancer
|
2008
|
0.91
|
|
16
|
G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cells.
|
Chem Biol Interact
|
2013
|
0.87
|
|
17
|
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.
|
J Biol Chem
|
2011
|
0.86
|
|
18
|
Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.
|
Sci Signal
|
2013
|
0.86
|
|
19
|
Suppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent.
|
Cancer Prev Res (Phila)
|
2012
|
0.82
|
|
20
|
OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling.
|
Carcinogenesis
|
2009
|
0.77
|
|
21
|
Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus.
|
Bioorg Med Chem
|
2012
|
0.77
|
|
22
|
Sensitivity to the non-COX inhibiting celecoxib derivative, OSU03012, is p21(WAF1/CIP1) dependent.
|
Int J Cancer
|
2008
|
0.77
|