Stephen J Polyak

Author PubWeight™ 43.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins. Virology 2002 2.55
2 Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology 2010 1.92
3 A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One 2010 1.62
4 Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol 2002 1.44
5 Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection. Gastroenterology 2009 1.40
6 Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology 2012 1.36
7 Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation. PLoS One 2011 1.27
8 Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C. J Infect Dis 2006 1.19
9 Expressed gene clusters associated with cellular sensitivity and resistance towards anti-viral and anti-proliferative actions of interferon. J Mol Biol 2004 1.18
10 Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection. J Virol 2006 1.12
11 Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop. Hepatology 2008 1.11
12 Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J Virol 2004 1.10
13 Effects of the hepatitis C virus core protein on innate cellular defense pathways. J Interferon Cytokine Res 2004 1.09
14 Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. Virol J 2005 1.08
15 Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C. Hepatology 2005 1.05
16 Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity. Alcohol Clin Exp Res 2006 1.05
17 Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. J Gastroenterol Hepatol 2010 1.03
18 A versatile ribosomal protein promoter-based reporter system for selective assessment of RNA stability and post-transcriptional control. RNA 2010 0.98
19 Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection. J Virol 2013 0.98
20 Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking. Cell Microbiol 2013 0.97
21 Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism. J Hepatol 2011 0.97
22 Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancer. Clin Cancer Res 2013 0.96
23 Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes. J Hepatol 2013 0.96
24 Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Biochemistry 2007 0.96
25 In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models. ACS Nano 2012 0.91
26 Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection. Virol J 2006 0.89
27 Relationships between hepatitis C virus replication and CXCL-8 production in vitro. J Virol 2006 0.89
28 Stability of CXCL-8 and related AU-rich mRNAs in the context of hepatitis C virus replication in vitro. J Infect Dis 2006 0.88
29 Enhanced bioactivity of silybin B methylation products. Bioorg Med Chem 2012 0.87
30 Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology 2013 0.86
31 Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation. PLoS One 2012 0.86
32 Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling. J Nat Prod 2015 0.83
33 Hepatitis C virus-host interactions: the NS5A protein and the interferon/chemokine systems. J Interferon Cytokine Res 2002 0.83
34 Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle. Bioorg Med Chem 2013 0.82
35 Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking. Antiviral Res 2013 0.79
36 Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology 2007 0.79
37 Antiviral effects of silymarin against hepatitis C: the jury is still out. Hepatology 2008 0.78
38 HCV research 20 years after discovery: a summary of the 16th international symposium on hepatitis C virus and related viruses. Gastroenterology 2009 0.77
39 Functional characterization of core genes from patients with acute hepatitis C virus infection. J Infect Dis 2010 0.76
40 Enantioselective synthesis, stereochemical correction, and biological investigation of the rodgersinine family of 1,4-benzodioxane neolignans. Org Lett 2015 0.75
41 Detection of hepatitis C virus RNA in normal cervical smears. Clin Infect Dis 2003 0.75
42 The circulatory orbit of micro-RNAs in hepatitis C. Hepatology 2013 0.75