N J Wareham

Author PubWeight™ 203.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997 7.33
2 Diabetes risk score: towards earlier detection of type 2 diabetes in general practice. Diabetes Metab Res Rev 2000 4.01
3 Interventions to prevent weight gain: a systematic review of psychological models and behaviour change methods. Int J Obes Relat Metab Disord 2000 3.90
4 Reliability and validity of the combined heart rate and movement sensor Actiheart. Eur J Clin Nutr 2005 3.84
5 The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening. Int J Obes Relat Metab Disord 2000 3.83
6 The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol 2003 2.89
7 Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study. Eur J Clin Nutr 2003 2.68
8 The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion. Diabet Med 1995 2.56
9 Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia 2011 2.43
10 The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int J Obes (Lond) 2007 2.37
11 Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia 2007 2.23
12 A confidential enquiry into deaths caused by asthma in an English health region: implications for general practice. Br J Gen Pract 1996 2.22
13 Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project. Diabet Med 1995 2.20
14 Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction. Am J Respir Crit Care Med 2001 2.11
15 Sample size determination for studies of gene-environment interaction. Int J Epidemiol 2001 2.11
16 Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis. Diabetologia 2009 1.96
17 Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct. Diabetologia 2013 1.93
18 How much does screening bring forward the diagnosis of type 2 diabetes and reduce complications? Twelve year follow-up of the Ely cohort. Diabetologia 2012 1.89
19 Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia 2012 1.87
20 Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 2009 1.81
21 Elevated plasma adiponectin in humans with genetically defective insulin receptors. J Clin Endocrinol Metab 2006 1.71
22 Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study. Diabetologia 2008 1.70
23 Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000. Diabet Med 2007 1.67
24 Derivation and validation of diabetes risk score for urban Asian Indians. Diabetes Res Clin Pract 2005 1.66
25 A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome. Br J Nutr 2000 1.66
26 Cardiovascular risk assessment scores for people with diabetes: a systematic review. Diabetologia 2009 1.65
27 Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 2007 1.60
28 Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia 2007 1.59
29 Cigarette smoking and glycaemia: the EPIC-Norfolk Study. European Prospective Investigation into Cancer. Int J Epidemiol 2001 1.56
30 Evidence for gene-nutrient interaction at the PPARgamma locus. Diabetes 2001 1.54
31 Implications of the United Kingdom Prospective Diabetes Study for general practice care of type 2 diabetes. Br J Gen Pract 1999 1.53
32 Psychological distress, major depressive disorder, and risk of stroke. Neurology 2008 1.52
33 What determines the cost-effectiveness of diabetes screening? Diabetologia 2006 1.51
34 Non-diabetic hyperglycaemia and cardiovascular risk: moving beyond categorisation to individual interpretation of absolute risk. Diabetologia 2010 1.49
35 Correlated measurement error--implications for nutritional epidemiology. Int J Epidemiol 2004 1.49
36 Who attends a UK diabetes screening programme? Findings from the ADDITION-Cambridge study. Diabet Med 2010 1.48
37 Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis. Eur J Clin Nutr 2012 1.46
38 Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening. Trials 2010 1.45
39 Estimation of magnitude in gene-environment interactions in the presence of measurement error. Stat Med 2004 1.41
40 Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. Diabetes Care 2011 1.39
41 Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort. Diabetologia 2010 1.39
42 Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial. Diabetologia 2008 1.39
43 Is platelet phospholipid-dependent thrombin generation altered by acute myocardial infarction or aspirin? Thromb Res 1996 1.38
44 Family history of diabetes identifies a group at increased risk for the metabolic consequences of obesity and physical inactivity in EPIC-Norfolk: a population-based study. The European Prospective Investigation into Cancer. Int J Obes Relat Metab Disord 2000 1.37
45 The performance of a risk score in predicting undiagnosed hyperglycemia. Diabetes Care 2002 1.36
46 Do simple questions about diet and physical activity help to identify those at risk of Type 2 diabetes? Diabet Med 2007 1.30
47 Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study. Eur J Clin Nutr 2001 1.29
48 Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia 2012 1.29
49 Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care 2000 1.28
50 Refractive error, axial length and anterior chamber depth of the eye in British adults: the EPIC-Norfolk Eye Study. Br J Ophthalmol 2010 1.28
51 The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study. Diabetologia 2012 1.28
52 Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. Diabetologia 2006 1.27
53 Accessibility and health service utilization for asthma in Norfolk, England. J Public Health Med 1998 1.27
54 Objectively measured physical activity correlates with indices of insulin resistance in Danish children. The European Youth Heart Study (EYHS). Int J Obes Relat Metab Disord 2004 1.25
55 What is the risk of mortality for people who are screen positive in a diabetes screening programme but who do not have diabetes on biochemical testing? Diabetes screening programmes from a public health perspective. J Med Screen 2002 1.24
56 The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial. Diabetologia 2010 1.23
57 Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study. J Intern Med 2007 1.22
58 The validation of physical activity instruments for measuring energy expenditure: problems and pitfalls. Public Health Nutr 1998 1.21
59 Do different dimensions of the metabolic syndrome change together over time? Evidence supporting obesity as the central feature. Diabetes Care 2001 1.20
60 A cross-sectional analysis of physical activity and obesity indicators in European participants of the EPIC-PANACEA study. Int J Obes (Lond) 2009 1.18
61 Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids. Diabetologia 1994 1.18
62 Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study. Diabetologia 2012 1.17
63 The association of intensity and overall level of physical activity energy expenditure with a marker of insulin resistance. Diabetologia 2008 1.17
64 Genetic predisposition to obesity leads to increased risk of type 2 diabetes. Diabetologia 2011 1.17
65 Fat consumption and HbA(1c) levels: the EPIC-Norfolk study. Diabetes Care 2001 1.15
66 How much might achievement of diabetes prevention behaviour goals reduce the incidence of diabetes if implemented at the population level? Diabetologia 2006 1.14
67 Frequent salad vegetable consumption is associated with a reduction in the risk of diabetes mellitus. J Clin Epidemiol 1999 1.14
68 Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia 2009 1.13
69 Measurement error in epidemiology: the design of validation studies II: bivariate situation. Stat Med 1999 1.12
70 How should peripheral neuropathy be assessed in people with diabetes in primary care? A population-based comparison of four measures. Diabet Med 2003 1.11
71 Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study. J Intern Med 2004 1.11
72 The threshold for diagnosing impaired fasting glucose: a position statement by the European Diabetes Epidemiology Group. Diabetologia 2006 1.07
73 Screening for diabetes using an oral glucose tolerance test within a western multi-ethnic population identifies modifiable cardiovascular risk: the ADDITION-Leicester study. Diabetologia 2011 1.07
74 Dietary antioxidants and asthma in adults. Thorax 2006 1.07
75 Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women. Int J Obes (Lond) 2009 1.06
76 Respiratory function and self-reported functional health: EPIC-Norfolk population study. Eur Respir J 2005 1.04
77 Low faecal elastase 1 concentrations in type 2 diabetes mellitus. Scand J Gastroenterol 2001 1.04
78 Screening for type 2 diabetes. Lessons from the ADDITION-Europe study. Diabet Med 2011 1.02
79 The changing classification and diagnosis of diabetes. New classification is based on pathogenesis, not insulin dependence. BMJ 1998 1.02
80 Studies of the SIM1 gene in relation to human obesity and obesity-related traits. Int J Obes (Lond) 2006 1.01
81 Smoking and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 2012 1.01
82 Psychosocial factors and incident asthma hospital admissions in the EPIC-Norfolk cohort study. Allergy 2007 1.00
83 No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach. Diabetologia 2011 0.99
84 Effects of body size and sociodemographic characteristics on differences between self-reported and measured anthropometric data in middle-aged men and women: the EPIC-Norfolk study. Eur J Clin Nutr 2010 0.99
85 No evidence of an increased mortality risk associated with low levels of glycated haemoglobin in a non-diabetic UK population. Diabetologia 2011 0.99
86 Rate of weight gain predicts change in physical activity levels: a longitudinal analysis of the EPIC-Norfolk cohort. Int J Obes (Lond) 2012 0.99
87 Habitual fish consumption and glycated haemoglobin: the EPIC-Norfolk study. Eur J Clin Nutr 2004 0.98
88 Does physical activity equally predict gain in fat mass among obese and nonobese young adults? Int J Obes (Lond) 2006 0.98
89 Eating out, weight and weight gain. A cross-sectional and prospective analysis in the context of the EPIC-PANACEA study. Int J Obes (Lond) 2010 0.97
90 Intake of total, animal and plant protein and subsequent changes in weight or waist circumference in European men and women: the Diogenes project. Int J Obes (Lond) 2010 0.97
91 Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism 2004 0.96
92 Are insulin resistance, impaired fasting glucose and impaired glucose tolerance all equally strongly related to age? Diabet Med 2005 0.96
93 Cost-effectiveness of alternative methods for diabetic retinopathy screening. Diabetes Care 1993 0.96
94 Physical health-related quality of life predicts stroke in the EPIC-Norfolk. Neurology 2007 0.96
95 How much might cardiovascular disease risk be reduced by intensive therapy in people with screen-detected diabetes? Diabet Med 2008 0.95
96 Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples. Int J Obes (Lond) 2012 0.95
97 Dietary glycaemic index, glycaemic load and subsequent changes of weight and waist circumference in European men and women. Int J Obes (Lond) 2009 0.95
98 Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia 2013 0.93
99 Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study. J Lipid Res 2009 0.93
100 Cardiorespiratory fitness and physical activity in Luo, Kamba, and Maasai of rural Kenya. Am J Hum Biol 2012 0.93
101 Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease. Diabetologia 2011 0.93
102 A combined heart rate and movement sensor: proof of concept and preliminary testing study. Eur J Clin Nutr 2000 0.92
103 Physical activity patterns in a nationally representative sample of adults in Ireland. Public Health Nutr 2001 0.91
104 Absolute level and rate of change of albuminuria over 1 year independently predict mortality and cardiovascular events in patients with diabetic nephropathy. Diabet Med 2003 0.91
105 Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites. FASEB J 2008 0.91
106 The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals. Int J Obes (Lond) 2008 0.91
107 Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. Int J Obes Relat Metab Disord 2001 0.90
108 Childhood smoking is an independent risk factor for obstructive airways disease in women. Thorax 2004 0.90
109 Cross-sectional but not longitudinal associations between non-esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome. Diabet Med 1999 0.89
110 Altered respiratory function is associated with increased metabolic risk, independently of adiposity, fitness and physical activity. Diabet Med 2009 0.88
111 Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. J Intern Med 2012 0.88
112 Estimating the potential population impact of stepwise screening strategies for identifying and treating individuals at high risk of Type 2 diabetes: a modelling study. Diabet Med 2012 0.88
113 Self-reported and measured anthropometric data and risk of colorectal cancer in the EPIC-Norfolk study. Int J Obes (Lond) 2011 0.88
114 The CART gene and human obesity: mutational analysis and population genetics. Diabetes 2000 0.87
115 Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes. Diabetologia 2006 0.87
116 PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge. Diabetologia 2007 0.87
117 Is the association between dietary fat intake and insulin resistance modified by physical activity? Metabolism 2001 0.86
118 Association between serotonin 5-HT-2C receptor gene (HTR2C) polymorphisms and obesity- and mental health-related phenotypes in a large population-based cohort. Int J Obes (Lond) 2010 0.86
119 Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF-beta levels. Atherosclerosis 1998 0.85
120 Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men. Biochim Biophys Acta 2003 0.85
121 Prospective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity. Int J Obes Relat Metab Disord 1999 0.85
122 Researching how to realize the potential of diabetes prevention. Diabet Med 2007 0.85
123 Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. Int J Obes Relat Metab Disord 2004 0.85
124 Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 2012 0.85
125 Effect of screening for Type 2 diabetes on population-level self-rated health outcomes and measures of cardiovascular risk: 13-year follow-up of the Ely cohort. Diabet Med 2012 0.85
126 Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British cohort study. J Nutr Health Aging 2015 0.84
127 Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women. Diabet Med 1997 0.84
128 The association of lifetime alcohol use with measures of abdominal and general adiposity in a large-scale European cohort. Eur J Clin Nutr 2011 0.83
129 Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study. Biochim Biophys Acta 2001 0.83
130 PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene x environment interactions in children from the European Youth Heart Study. Diabetologia 2009 0.83
131 Patterns of physical activity and ultrasound attenuation by heel bone among Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): population based study. BMJ 2001 0.82
132 Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study. Eur J Clin Nutr 2002 0.82
133 PARL Leu262Val is not associated with fasting insulin levels in UK populations. Diabetologia 2006 0.82
134 Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. European Prospective Investigation into Cancer and Nutrition. Eur Respir J 2000 0.82
135 Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations. Diabetologia 2007 0.82
136 Does early intensive multifactorial therapy reduce modelled cardiovascular risk in individuals with screen-detected diabetes? Results from the ADDITION-Europe cluster randomized trial. Diabet Med 2014 0.82
137 Excessive secretion of insulin precursors characterizes and predicts gestational diabetes. Diabetes 1995 0.81
138 A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men. Atherosclerosis 2000 0.81
139 Inflammatory biomarkers and the prediction of coronary events among people at intermediate risk: the EPIC-Norfolk prospective population study. Heart 2009 0.81
140 Hormone replacement therapy and glucose tolerance in EPIC-Norfolk: a population-based study. Diabetes Metab Res Rev 2000 0.80
141 Factor VII, blood lipids and fat intake: gene-nutrient interaction and risk of coronary heart disease with the factor VII R353Q polymorphism. Eur J Clin Nutr 2008 0.80
142 The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity. J Clin Endocrinol Metab 2001 0.80
143 Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study. J Intern Med 2011 0.80
144 The effect of varying the screening interval on false positives and duration of undiagnosed disease in a screening programme for type 2 diabetes. J Med Screen 2000 0.79
145 Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. Int J Obes (Lond) 2013 0.79
146 Fibre intake in relation to serum total cholesterol levels and CHD risk: a comparison of dietary assessment methods. Eur J Clin Nutr 2011 0.78
147 The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide. Atherosclerosis 1996 0.78
148 Benign recurrent intrahepatic cholestasis. J R Soc Med 1985 0.78
149 Screening for coeliac disease: what evidence is required before population programmes could be considered? Arch Dis Child 2004 0.78
150 The association of education with long-term weight change in the EPIC-PANACEA cohort. Eur J Clin Nutr 2012 0.78
151 Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. J Thromb Haemost 2006 0.78
152 Change in HbA1c over 3 years does not improve the prediction of cardiovascular disease over and above HbA1c measured at a single time point. Diabetologia 2013 0.77
153 Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial. Diabet Med 2012 0.77
154 Relationship between plasma fibrinogen and fiber intake in the EPIC-Norfolk cohort. Eur J Clin Nutr 2011 0.77
155 Changes in diet, cardiovascular risk factors and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort. Diabet Med 2013 0.77
156 The association between prior infection with five serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the EPIC-Norfolk study. Diabetologia 2012 0.76
157 Estimating energy expenditure by heart-rate monitoring without individual calibration. Med Sci Sports Exerc 2001 0.76
158 Changes in physical activity and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort. Diabet Med 2013 0.76
159 Analysis of TBC1D4 in patients with severe insulin resistance. Diabetologia 2010 0.76
160 Is an exaggerated postprandial triglyceride response associated with the component features of the insulin resistance syndrome? Diabet Med 1997 0.76
161 Fibrinogen plasma levels modify the association between the factor XIII Val34Leu variant and risk of coronary artery disease: the EPIC-Norfolk prospective population study. J Thromb Haemost 2006 0.76
162 Using cohort studies in lifecourse epidemiology. Public Health 2012 0.75
163 Autografting for chronic granulocytic leukemia. N Engl J Med 1981 0.75
164 The diagnosis and classification of diabetes mellitus in nonpregnant adults. Prim Care 1999 0.75
165 Relationship of the duration of the chronic phase in chronic granulocytic leukaemia to the need for treatment during the first year after diagnosis. Cancer Chemother Pharmacol 1982 0.75
166 Hypertension and its treatment influence changes in fasting nonesterified fatty acid concentrations: a link between the sympathetic nervous system and the metabolic syndrome? Metabolism 2000 0.75
167 The role of insulin and proinsulin in the regulation of triglyceride metabolism. Exp Clin Endocrinol Diabetes 1997 0.75
168 Descriptive epidemiology short reports in Diabetic Medicine--an opportunity to present data with the population as the unit of variation. Diabet Med 2000 0.75
169 Gestational diabetes mellitus is associated with an increase in the total concentration of amylin molecules. Diabetes Care 1998 0.75
170 Chemotherapy and autografting for chronic granulocytic leukaemia in transformation: probable prolongation of survival for some patients. Br J Haematol 1984 0.75
171 Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance. Diabetologia 1995 0.75
172 Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity. J Appl Physiol (1985) 2007 0.75