Published in Drug Discov Today on February 17, 2010
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
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Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function. Am J Physiol Regul Integr Comp Physiol (2003) 1.32
Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring. Hypertension (2008) 1.28
Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring. J Pharmacol Exp Ther (2007) 1.28
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Foetal nicotine exposure causes PKCε gene repression by promoter methylation in rat hearts. Cardiovasc Res (2010) 1.14
Fetal and neonatal nicotine exposure differentially regulates vascular contractility in adult male and female offspring. J Pharmacol Exp Ther (2006) 1.14
Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C epsilon. J Pharmacol Exp Ther (2009) 1.11
Direct effect of cocaine on epigenetic regulation of PKCepsilon gene repression in the fetal rat heart. J Mol Cell Cardiol (2009) 1.09
Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway. Am J Physiol Heart Circ Physiol (2006) 1.09
Prenatal cocaine exposure increases heart susceptibility to ischaemia-reperfusion injury in adult male but not female rats. J Physiol (2005) 1.06
ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy. Am J Physiol Heart Circ Physiol (2002) 1.06
Norepinephrine causes epigenetic repression of PKCε gene in rodent hearts by activating Nox1-dependent reactive oxygen species production. FASEB J (2012) 1.05
Hypoxia-derived oxidative stress mediates epigenetic repression of PKCε gene in foetal rat hearts. Cardiovasc Res (2011) 1.05
Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring. Biol Reprod (2008) 1.04
Chronic hypoxia during gestation causes epigenetic repression of the estrogen receptor-α gene in ovine uterine arteries via heightened promoter methylation. Hypertension (2012) 1.03
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The effect of prenatal nicotine on expression of nicotine receptor subunits in the fetal brain. Neurotoxicology (2008) 1.01
Direct chronic effect of steroid hormones in attenuating uterine arterial myogenic tone: role of protein kinase c/extracellular signal-regulated kinase 1/2. Hypertension (2009) 1.01
Maturation and the role of PKC-mediated contractility in ovine cerebral arteries. Am J Physiol Heart Circ Physiol (2009) 1.01
Prenatal cocaine exposure increases apoptosis of neonatal rat heart and heart susceptibility to ischemia-reperfusion injury in 1-month-old rat. Br J Pharmacol (2005) 1.00
Chronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy. Hypertension (2010) 0.98
Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts: role of PKCepsilon. Am J Physiol Heart Circ Physiol (2009) 0.98
Pregnancy upregulates large-conductance Ca(2+)-activated K(+) channel activity and attenuates myogenic tone in uterine arteries. Hypertension (2011) 0.98
Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. Stroke (2012) 0.98
Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions. Prog Neurobiol (2012) 0.97
Chronic hypoxia suppresses pregnancy-induced upregulation of large-conductance Ca2+-activated K+ channel activity in uterine arteries. Hypertension (2012) 0.97
Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway. Am J Physiol Heart Circ Physiol (2009) 0.97
Gestational hypoxia induces preeclampsia-like symptoms via heightened endothelin-1 signaling in pregnant rats. Hypertension (2013) 0.96
Adaptation of uterine artery thick- and thin-filament regulatory pathways to pregnancy. Am J Physiol Heart Circ Physiol (2004) 0.95
Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells. Drug Discov Today (2012) 0.95
Effects of chronic hypoxia on maternal vasodilation and vascular reactivity in guinea pig and ovine pregnancy. High Alt Med Biol (2003) 0.93
Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspring. Br J Pharmacol (2011) 0.92
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Hypoxia inhibits cardiomyocyte proliferation in fetal rat hearts via upregulating TIMP-4. Am J Physiol Regul Integr Comp Physiol (2013) 0.92
Role of the hypothalamic-pituitary-adrenal axis in developmental programming of health and disease. Front Neuroendocrinol (2012) 0.92
Regulation of alpha1-adrenoceptor-mediated contractions of uterine arteries by PKC: effect of pregnancy. Am J Physiol Heart Circ Physiol (2006) 0.92
Development of AT(1) and AT(2) receptors in the ovine fetal brain. Brain Res Dev Brain Res (2004) 0.92
Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC. Am J Physiol Heart Circ Physiol (2005) 0.91
Estrogen normalizes perinatal nicotine-induced hypertensive responses in adult female rat offspring. Hypertension (2013) 0.91
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Short- and long-term adverse effects of cocaine abuse during pregnancy on the heart development. Ther Adv Cardiovasc Dis (2009) 0.90
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Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats. Am J Physiol Heart Circ Physiol (2011) 0.90
Prenatal exposure to nicotine with associated in utero hypoxia decreased fetal brain muscarinic mRNA in the rat. Brain Res (2007) 0.89
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High-salt diet during pregnancy and angiotensin-related cardiac changes. J Hypertens (2010) 0.89
Vasopressin mechanism-mediated pressor responses caused by central angiotensin II in the ovine fetus. Pediatr Res (2004) 0.89
Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats. Cardiovasc Res (2013) 0.88
Chronic hypoxia during gestation enhances uterine arterial myogenic tone via heightened oxidative stress. PLoS One (2013) 0.88
The effect of fetal and neonatal nicotine exposure on renal development of AT(1) and AT(2) receptors. Reprod Toxicol (2009) 0.88
Direct effects of nicotine on contractility of the uterine artery in pregnancy. J Pharmacol Exp Ther (2007) 0.88
Epigenetic mechanisms in developmental programming of adult disease. Drug Discov Today (2011) 0.88
Fetal and adult cerebral artery K(ATP) and K(Ca) channel responses to long-term hypoxia. J Appl Physiol (1985) (2002) 0.87
Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring. Hypertension (2009) 0.87
Chronic hypoxia alters the function of NOS nerves in cerebral arteries of near-term fetal and adult sheep. J Appl Physiol (1985) (2002) 0.87
Nitric oxide inhibits ACTH-induced cortisol production in near-term, long-term hypoxic ovine fetal adrenocortical cells. Reprod Sci (2010) 0.87
PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries. Am J Physiol Regul Integr Comp Physiol (2005) 0.86
alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries. Am J Physiol Heart Circ Physiol (2010) 0.86
Promoter methylation represses AT2R gene and increases brain hypoxic-ischemic injury in neonatal rats. Neurobiol Dis (2013) 0.86
Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility. Am J Physiol Regul Integr Comp Physiol (2010) 0.86
Pregnancy downregulates actin polymerization and pressure-dependent myogenic tone in ovine uterine arteries. Hypertension (2010) 0.85
Calcium homeostasis and contraction of the uterine artery: effect of pregnancy and chronic hypoxia. Biol Reprod (2003) 0.85
Chronic exercise normalizes changes in Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats. Br J Pharmacol (2015) 0.85
Regulation of baseline Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy. Am J Physiol Heart Circ Physiol (2006) 0.85
Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are age dependent in fetal and adult ovine carotid arteries. J Appl Physiol (1985) (2006) 0.85
Losartan chemistry and its effects via AT1 mechanisms in the kidney. Curr Med Chem (2009) 0.85
Hepatic insulin signaling changes: possible mechanism in prenatal hypoxia-increased susceptibility of fatty liver in adulthood. Endocrinology (2012) 0.85
Cortisol-mediated potentiation of uterine artery contractility: effect of pregnancy. Am J Physiol Heart Circ Physiol (2002) 0.84
Changes of renal AT1/AT2 receptors and structures in ovine fetuses following exposure to long-term hypoxia. Am J Nephrol (2009) 0.84
Cardiovascular effects of losartan and its relevant clinical application. Curr Med Chem (2009) 0.84
Fetal functional capabilities in response to maternal hypertonicity associated with altered central and peripheral angiotensinogen mRNA in rats. Peptides (2007) 0.84