Published in Bone on February 18, 2010
Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales. Proc Natl Acad Sci U S A (2011) 1.49
Dilatational band formation in bone. Proc Natl Acad Sci U S A (2012) 1.32
Nanoscale morphology of Type I collagen is altered in the Brtl mouse model of Osteogenesis Imperfecta. J Struct Biol (2010) 1.08
Effects of bone matrix proteins on fracture and fragility in osteoporosis. Curr Osteoporos Rep (2012) 1.08
Type XII collagen regulates osteoblast polarity and communication during bone formation. J Cell Biol (2011) 1.06
Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice. J Bone Miner Res (2014) 0.99
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One (2011) 0.95
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. EMBO Rep (2010) 0.95
Increased susceptibility to microdamage in Brtl/+ mouse model for osteogenesis imperfecta. Bone (2011) 0.89
Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biol (2011) 0.87
The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness. Bone (2014) 0.85
Structural analysis of cortical porosity applied to HR-pQCT data. Med Phys (2014) 0.83
The fracture mechanics of human bone: influence of disease and treatment. Bonekey Rep (2015) 0.83
Multifunctional ECM proteins in bone and teeth. Exp Cell Res (2014) 0.82
Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells. Food Chem Toxicol (2011) 0.79
Computational and experimental methodology for site-matched investigations of the influence of mineral mass fraction and collagen orientation on the axial indentation modulus of lamellar bone. J Mech Behav Biomed Mater (2013) 0.78
Contribution of extrafibrillar matrix to the mechanical behavior of bone using a novel cohesive finite element model. J Mech Behav Biomed Mater (2016) 0.77
Mechanisms of otoconia and otolith development. Dev Dyn (2014) 0.77
Effect of low-level laser therapy on bone repair: a randomized controlled experimental study. Lasers Med Sci (2015) 0.77
Polarization in Raman spectroscopy helps explain bone brittleness in genetic mouse models. J Biomed Opt (2014) 0.77
Biological regulation of bone quality. Curr Osteoporos Rep (2014) 0.77
A new piezoelectric actuator induces bone formation in vivo: a preliminary study. J Biomed Biotechnol (2012) 0.76
Intrinsically disordered proteins and biomineralization. Matrix Biol (2016) 0.76
Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype. J Appl Physiol (1985) (2015) 0.75
Insights into the effects of tensile and compressive loadings on human femur bone. Adv Biomed Res (2014) 0.75
Coupling Effect of Water and Proteoglycans on the In Situ Toughness of Bone. J Bone Miner Res (2016) 0.75
Do Non-collagenous Proteins Affect Skeletal Mechanical Properties? Calcif Tissue Int (2015) 0.75
Hydroxyapatite-collagen composites. Part I: can the decrease of the interactions between the two components be a physicochemical component of osteoporosis in aged bone? J Mater Sci Mater Med (2011) 0.75
Applying Full Spectrum Analysis to a Raman Spectroscopic Assessment of Fracture Toughness of Human Cortical Bone. Appl Spectrosc (2017) 0.75
Osteopontin in bone mineral density of very old Brazilians. J Bone Miner Metab (2013) 0.75
Biomineralization of Fucoidan-Peptide Blends and Their Potential Applications in Bone Tissue Regeneration. J Funct Biomater (2017) 0.75
Toughening of fibrous scaffolds by mobile mineral deposits. Acta Biomater (2017) 0.75
Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone (2004) 5.27
Mechanistic fracture criteria for the failure of human cortical bone. Nat Mater (2003) 4.05
Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest (1998) 3.56
Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nat Mater (2005) 3.35
The true toughness of human cortical bone measured with realistically short cracks. Nat Mater (2008) 3.03
Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem J (1996) 2.89
From brittle to ductile fracture of bone. Nat Mater (2005) 2.76
Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int (2010) 2.69
Cooperative deformation of mineral and collagen in bone at the nanoscale. Proc Natl Acad Sci U S A (2006) 2.68
Nucleation of hydroxyapatite by bone sialoprotein. Proc Natl Acad Sci U S A (1993) 2.50
Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res (1998) 2.49
Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res (2005) 2.41
Bone mineralization density distribution in health and disease. Bone (2007) 2.35
Osteopontin: a versatile regulator of inflammation and biomineralization. Matrix Biol (2000) 2.24
Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone (1998) 2.20
Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy. Nat Nanotechnol (2009) 2.19
Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner (1993) 2.16
The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res (1999) 2.05
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A (1999) 2.04
Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone. Calcif Tissue Int (2002) 1.91
The design of mineralised hard tissues for their mechanical functions. J Exp Biol (1999) 1.88
Effects of non-enzymatic glycation on cancellous bone fragility. Bone (2006) 1.87
TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A (2005) 1.83
Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6. J Biomech (2004) 1.78
Calcium and collagen binding properties of osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 from bone. J Biol Chem (1992) 1.74
Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice. J Bone Miner Res (2007) 1.73
Crack growth resistance in cortical bone: concept of microcrack toughening. J Biomech (1997) 1.69
Measurement of the toughness of bone: a tutorial with special reference to small animal studies. Bone (2008) 1.65
Molecular modulation of calcium oxalate crystallization by osteopontin and citrate. Proc Natl Acad Sci U S A (2004) 1.64
A biomechanical perspective on bone quality. Bone (2006) 1.53
The influence of bone morphology on fracture toughness of the human femur and tibia. Bone (1997) 1.51
Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength. J Bone Miner Res (2004) 1.47
Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro- and nano-CT. J Bone Miner Res (2007) 1.33
The role of the collagen matrix in skeletal fragility. Curr Osteoporos Rep (2007) 1.32
Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor. J Biol Chem (1988) 1.32
Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair. Microsc Res Tech (1996) 1.27
Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse. J Bone Miner Res (2005) 1.21
Nanoscale ion mediated networks in bone: osteopontin can repeatedly dissipate large amounts of energy. Nano Lett (2007) 1.18
Microstructural heterogeneity and the fracture toughness of bone. J Biomed Mater Res (2000) 1.18
Molecular recognition at the protein-hydroxyapatite interface. Crit Rev Oral Biol Med (2003) 1.08
Exercise alters mineral and matrix composition in the absence of adding new bone. Cells Tissues Organs (2008) 1.07
TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone (2003) 1.07
In situ observation of fluoride-ion-induced hydroxyapatite-collagen detachment on bone fracture surfaces by atomic force microscopy. Nanotechnology (2007) 1.07
Identification of the type I collagen-binding domain of bone sialoprotein and characterization of the mechanism of interaction. J Biol Chem (2005) 1.02
Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone (2009) 1.01
Time-lapsed assessment of microcrack initiation and propagation in murine cortical bone at submicrometer resolution. Bone (2009) 1.00
Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res (2002) 0.99
Osteopontin deficiency and aging on nanomechanics of mouse bone. J Biomed Mater Res A (2007) 0.97
Different approaches to bone densitometry. J Nucl Med (2000) 0.96
Short-term exercise in mice increases tibial post-yield mechanical properties while two weeks of latency following exercise increases tissue-level strength. Calcif Tissue Int (2009) 0.95
Osteopontin facilitates bone resorption, decreasing bone mineral crystallinity and content during calcium deficiency. Calcif Tissue Int (2003) 0.95
Content and distribution of noncollagenous matrix proteins in bone and cementum: relationship to speed of formation and collagen packing density. J Struct Biol (1999) 0.94
Hierarchies of extracellular matrix and mineral organization in bone of the craniofacial complex and skeleton. Cells Tissues Organs (2005) 0.90
Compressive properties of cortical bone: mineral-organic interfacial bonding. Biomaterials (1994) 0.89
The distribution of soluble, mineral-bound, and matrix-bound proteins in osteoporotic and normal bones. Bone (1995) 0.89
Effect of Ca2+ ions on the adhesion and mechanical properties of adsorbed layers of human osteopontin. Biophys J (2008) 0.87
Monte Carlo simulations of electron scattering in bone. Bone (1994) 0.87
Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts. Endocrinology (2006) 0.86
Tensile experiments and SEM fractography on bovine subchondral bone. J Biomech (2000) 0.85
Scanning electron microscopy of human cortical bone failure surfaces. J Biomech (1997) 0.83
Effects of sodium fluoride and alendronate on the bone mineral in minipigs: a small-angle X-ray scattering and backscattered electron imaging study. J Bone Miner Res (1996) 0.81
Changing the structurally effective mineral content of bone with in vitro fluoride treatment. J Biomech (2002) 0.80
A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80
A damage-tolerant glass. Nat Mater (2011) 3.91
Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med (2012) 2.80
Three-dimensional nanopillar-array photovoltaics on low-cost and flexible substrates. Nat Mater (2009) 2.64
Microindentation for in vivo measurement of bone tissue mechanical properties in humans. J Bone Miner Res (2010) 2.52
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J (2005) 2.35
TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A (2005) 1.83
The tissue diagnostic instrument. Rev Sci Instrum (2009) 1.82
Vitamin D deficiency induces early signs of aging in human bone, increasing the risk of fracture. Sci Transl Med (2013) 1.65
The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoids. Arthritis Rheum (2007) 1.65
Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One (2008) 1.60
Real-time quantitative imaging of failure events in materials under load at temperatures above 1,600 °C. Nat Mater (2012) 1.60
A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides. Environ Res (2007) 1.55
Pregnancy outcomes before and after a diagnosis of systemic lupus erythematosus. Am J Obstet Gynecol (2005) 1.50
Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales. Proc Natl Acad Sci U S A (2011) 1.49
Maternal hair--an appropriate matrix for detecting maternal exposure to pesticides during pregnancy. Environ Res (2006) 1.49
A novel biomimetic approach to the design of high-performance ceramic-metal composites. J R Soc Interface (2009) 1.46
Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation. Nat Mater (2009) 1.42
Efficient photovoltaic current generation at ferroelectric domain walls. Phys Rev Lett (2011) 1.40
The quest for stronger, tougher materials. Science (2008) 1.33
Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization. Arthritis Rheum (2008) 1.33
A 14-year retrospective maternal report of alcohol consumption in pregnancy predicts pregnancy and teen outcomes. Alcohol (2009) 1.29
Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone. Aging Cell (2010) 1.24
Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res (2012) 1.22
Executive summary: Evaluating the evidence base to support the inclusion of infants and children from birth to 24 mo of age in the Dietary Guidelines for Americans--"the B-24 Project". Am J Clin Nutr (2014) 1.18
Solution to the problem of the poor cyclic fatigue resistance of bulk metallic glasses. Proc Natl Acad Sci U S A (2009) 1.18
Canine cranial reconstruction using autologous bone marrow stromal cells. Am J Pathol (2006) 1.18
Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. J Biol Chem (2004) 1.14
ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation. Mol Biol Cell (2012) 1.14
Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum (2012) 1.08
The effect of aging on crack-growth resistance and toughening mechanisms in human dentin. Biomaterials (2007) 1.07
Medicine: interfering with bone remodelling. Nature (2002) 1.06
Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells (2013) 1.06
Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides. Environ Res (2008) 1.06
Structure and fracture resistance of alligator gar (Atractosteus spatula) armored fish scales. Acta Biomater (2012) 1.01
Natural flexible dermal armor. Adv Mater (2012) 1.01
Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. J Orthop Res (2013) 0.98
Prolonged treatments with antiresorptive agents and PTH have different effects on bone strength and the degree of mineralization in old estrogen-deficient osteoporotic rats. J Bone Miner Res (2009) 0.98
Mechanical adaptability of the Bouligand-type structure in natural dermal armour. Nat Commun (2013) 0.97
On the effect of X-ray irradiation on the deformation and fracture behavior of human cortical bone. Bone (2010) 0.97
Compositional modulation in In(x)Ga(1-x)N: TEM and X-ray studies. J Electron Microsc (Tokyo) (2005) 0.97
A benchmark dose analysis of prenatal exposure to polychlorinated biphenyls. Environ Health Perspect (2002) 0.97
Mixed-mode fracture of human cortical bone. Biomaterials (2009) 0.97
Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats. Bone (2009) 0.96
Fatty acid ethyl esters in meconium: are they biomarkers of fetal alcohol exposure and effect? Alcohol Clin Exp Res (2006) 0.96
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. EMBO Rep (2010) 0.95
Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice. Bone (2012) 0.95
Strain-induced indirect to direct bandgap transition in multilayer WSe2. Nano Lett (2014) 0.94
Analysis of the material properties of early chondrogenic differentiated adipose-derived stromal cells (ASC) using an in vitro three-dimensional micromass culture system. Biochem Biophys Res Commun (2007) 0.93
p-Type InP nanopillar photocathodes for efficient solar-driven hydrogen production. Angew Chem Int Ed Engl (2012) 0.92
Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone. Biomaterials (2011) 0.92
Size-dependent polar ordering in colloidal GeTe nanocrystals. Nano Lett (2011) 0.92
Fetal exposure to propoxur and abnormal child neurodevelopment at 2 years of age. Neurotoxicology (2011) 0.91
Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism. PLoS One (2013) 0.89
In vitro fatigue-crack growth and fracture toughness behavior of thin-walled superelastic Nitinol tube for endovascular stents: A basis for defining the effect of crack-like defects. Biomaterials (2006) 0.89
Unidirectional freezing of ceramic suspensions: in situ X-ray investigation of the effects of additives. ACS Appl Mater Interfaces (2013) 0.89
Stress-corrosion crack growth of Si-Na-K-Mg-Ca-P-O bioactive glasses in simulated human physiological environment. Biomaterials (2007) 0.87
The significance of crack-resistance curves to the mixed-mode fracture toughness of human cortical bone. Biomaterials (2010) 0.87
A direct thin-film path towards low-cost large-area III-V photovoltaics. Sci Rep (2013) 0.86
Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage. Biophys J (2013) 0.86
Enhanced fatigue endurance of metallic glasses through a staircase-like fracture mechanism. Proc Natl Acad Sci U S A (2013) 0.86
Local tissue properties of human osteoarthritic cartilage correlate with magnetic resonance T(1) rho relaxation times. J Orthop Res (2011) 0.85
Tetrapod nanocrystals as fluorescent stress probes of electrospun nanocomposites. Nano Lett (2013) 0.85
Differential maintenance of cortical and cancellous bone strength following discontinuation of bone-active agents. J Bone Miner Res (2011) 0.84
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium. ACS Chem Biol (2014) 0.83
Changes in REM-sleep percentage over the adult lifespan. Sleep (2007) 0.83
Modifications to nano- and microstructural quality and the effects on mechanical integrity in Paget's disease of bone. J Bone Miner Res (2015) 0.82
Elevated TGF-beta2 signaling in dentin results in sex related enamel defects. Arch Oral Biol (2007) 0.81
On the increasing fragility of human teeth with age: a deep-UV resonance Raman study. J Bone Miner Res (2006) 0.81
Mo-doped BiVO4 photoanodes synthesized by reactive sputtering. ChemSusChem (2015) 0.80
Quantum-coupled radial-breathing oscillations in double-walled carbon nanotubes. Nat Commun (2013) 0.80
Amorphous Si thin film based photocathodes with high photovoltage for efficient hydrogen production. Nano Lett (2013) 0.80
Efficient and sustained photoelectrochemical water oxidation by cobalt oxide/silicon photoanodes with nanotextured interfaces. J Am Chem Soc (2014) 0.78
An equivalent strain/Coffin-Manson approach to multiaxial fatigue and life prediction in superelastic Nitinol medical devices. Biomaterials (2011) 0.77
Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration. Laryngoscope (2013) 0.77
Nonepitaxial Thin-Film InP for Scalable and Efficient Photocathodes. J Phys Chem Lett (2015) 0.77
In situ Materials Characterization using the Tissue Diagnostic Instrument. Polym Test (2010) 0.77
Mixed-mode toughness of human cortical bone containing a longitudinal crack in far-field compression. Bone (2011) 0.76
β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes. Clin Orthop Relat Res (2015) 0.75
The use of polyacrylamide gels for mechanical calibration of cartilage--a combined nanoindentation and unconfined compression study. J Mech Behav Biomed Mater (2011) 0.75
Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage. NMR Biomed (2015) 0.75
Biological materials science. J Mech Behav Biomed Mater (2008) 0.75
Integrated microfluidic test-bed for energy conversion devices. Phys Chem Chem Phys (2013) 0.75
Control of defect concentrations within a semiconductor through adsorption. Phys Rev Lett (2006) 0.75