PubRank

Jeffrey E Saffitz

Author PubWeight™ 112.82‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation 2010 6.71
2 PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 2005 5.80
3 A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med 2009 4.54
4 Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J 2010 4.13
5 Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm 2004 3.54
6 Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res 2006 2.95
7 Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ Res 2002 2.94
8 Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res 2004 2.66
9 A national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: a stakeholder summit. Am J Clin Pathol 2011 2.58
10 Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A 2004 2.32
11 Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart. Circulation 2005 2.29
12 Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res 2004 2.25
13 3D MRI-based multicomponent FSI models for atherosclerotic plaques. Ann Biomed Eng 2004 2.17
14 c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res 2002 2.11
15 Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ Res 2006 1.97
16 A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet 2007 1.91
17 Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm 2012 1.91
18 Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment. Ann Biomed Eng 2005 1.89
19 Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks. Heart Rhythm 2010 1.85
20 Structural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol 2004 1.82
21 A call to action: training pathology residents in genomics and personalized medicine. Am J Clin Pathol 2010 1.81
22 Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm 2009 1.78
23 Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Circulation 2007 1.57
24 Matrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load. Circ Res 2005 1.55
25 A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Heart Rhythm 2011 1.54
26 Protein kinase Cepsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning. Heart Rhythm 2007 1.54
27 Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. Eur J Heart Fail 2012 1.51
28 Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43. Circ Res 2003 1.44
29 End stage of arrhythmogenic cardiomyopathy with severe involvement of the interventricular septum. Heart Rhythm 2012 1.40
30 Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models. J Biomech Eng 2005 1.38
31 Autocrine regulation of myocyte Cx43 expression by VEGF. Circ Res 2002 1.34
32 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol 2011 1.24
33 Echocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction. J Am Soc Echocardiogr 2002 1.24
34 Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J 2012 1.24
35 Mortality and morbidity in pre-sensitized pediatric heart transplant recipients with a positive donor crossmatch utilizing peri-operative plasmapheresis and cytolytic therapy. J Heart Lung Transplant 2007 1.18
36 Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch. Circ Res 2005 1.18
37 Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning. Circ Res 2003 1.17
38 Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol 2011 1.11
39 Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. J Biol Chem 2004 1.07
40 Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J Am Coll Cardiol 2003 1.06
41 Transmural distribution of connexins in rodent hearts. J Cardiovasc Electrophysiol 2004 1.05
42 Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem 2007 1.05
43 Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res 2002 1.03
44 Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation 2011 1.00
45 Cardiac ischemia activates calcium-independent phospholipase A2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiologic phenotype by mechanism-based inhibition. J Biol Chem 2003 1.00
46 Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem 2011 0.98
47 Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm 2009 0.98
48 Diminished zonula occludens-1 expression in the failing human heart. Cardiovasc Pathol 2007 0.96
49 Genomic oncology education: an urgent need, a new approach. Cancer J 2014 0.92
50 Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Cardiovasc Res 2010 0.92
51 Gap junction remodeling in a case of arrhythmogenic right ventricular dysplasia due to plakophilin-2 mutation. J Cardiovasc Electrophysiol 2008 0.91
52 Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy. Cardiovasc Res 2005 0.90
53 Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circ Res 2012 0.88
54 Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo. Magn Reson Med 2005 0.88
55 Unique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations. J Cutan Pathol 2008 0.87
56 Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy? Heart Rhythm 2010 0.87
57 Gap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm 2011 0.86
58 Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford) 2013 0.85
59 Desmosome mutations in arrhythmogenic right ventricular cardiomyopathy: important insight but only part of the picture. Circ Cardiovasc Genet 2009 0.85
60 Cardiac structure and function in young and senescent mice heterozygous for a connexin43 null mutation. J Mol Cell Cardiol 2002 0.84
61 Gap junctions, slow conduction, and ventricular tachycardia after myocardial infarction. J Am Coll Cardiol 2012 0.83
62 Sympathetic neural activity and the pathogenesis of sudden cardiac death. Heart Rhythm 2007 0.82
63 Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele. Cardiovasc Pathol 2011 0.81
64 The role of endomyocardial biopsy in ARVC: looking beyond histology in search of new diagnostic markers. J Cardiovasc Electrophysiol 2010 0.81
65 Connexins, conduction, and atrial fibrillation. N Engl J Med 2006 0.80
66 Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy. Cell Commun Adhes 2014 0.80
67 Is CaMKII a therapeutic target for ventricular rate control? Heart Rhythm 2005 0.79
68 Spontaneous and inducible ventricular arrhythmias after myocardial infarction in mice. Cardiovasc Pathol 2004 0.78
69 Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations. Cardiovasc Pathol 2013 0.78
70 Structural heart disease, SCN5A gene mutations, and Brugada syndrome: a complex ménage à trois. Circulation 2005 0.76
71 Non-ischemic left ventricular dysfunction after pediatric cardiac transplantation: treatment with plasmapheresis and OKT3. J Heart Lung Transplant 2004 0.76
72 Altered atrial structure begets atrial fibrillation, but how? J Cardiovasc Electrophysiol 2004 0.75
73 Pathologic basis of conduction disturbances: the challenge to move beyond microscopic anatomy. J Cardiovasc Electrophysiol 2002 0.75
74 Mutations in desmosomal protein genes and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm 2009 0.75
75 Expanding the spectrum of arrhythmogenic cardiomyopathy. J Am Coll Cardiol 2008 0.75
76 Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arterioscler Thromb Vasc Biol 2003 0.75