Published in J Bioenerg Biomembr on February 24, 2010
Prospects for minocycline neuroprotection. Arch Neurol (2010) 1.27
Acute minocycline treatment mitigates the symptoms of mild blast-induced traumatic brain injury. Front Neurol (2012) 1.20
Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol (2011) 0.93
Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol (2013) 0.88
Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. J Neuroimmune Pharmacol (2011) 0.88
Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells. J Biol Chem (2011) 0.83
Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock/resuscitation. Shock (2014) 0.78
Cytoprotective activity of minocycline includes improvement of mitochondrial coupling: the importance of minocycline concentration and the presence of VDAC. J Bioenerg Biomembr (2012) 0.76
Minocycline Promotes Neurite Outgrowth of PC12 Cells Exposed to Oxygen-Glucose Deprivation and Reoxygenation Through Regulation of MLCP/MLC Signaling Pathways. Cell Mol Neurobiol (2016) 0.75
Mechanisms by which mitochondria transport calcium. Am J Physiol (1990) 6.06
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature (2002) 4.21
Barrel-stave model or toroidal model? A case study on melittin pores. Biophys J (2001) 3.80
Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol (2006) 3.02
Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem (1997) 2.64
Minocycline and doxycycline are not beneficial in a model of Huntington's disease. Ann Neurol (2003) 2.57
Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem (1998) 2.32
Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A (2003) 2.05
Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem (2004) 1.79
Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential. Biochem J (1980) 1.76
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. Proc Natl Acad Sci U S A (2004) 1.63
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. J Am Coll Cardiol (2004) 1.12
A mechanism for tamoxifen-mediated inhibition of acidification. J Biol Chem (1999) 1.03
Inhibition of mitochondrial and plastid activity of Plasmodium falciparum by minocycline. FEBS Lett (2002) 1.02
Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. Neuroscience (2005) 0.99
Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline. Biochem Biophys Res Commun (2003) 0.97
Comparative kinetic analysis reveals that inducer-specific ion release precedes the mitochondrial permeability transition. Biochim Biophys Acta (2005) 0.96
Effects of minocycline on Fas-mediated fulminant hepatitis in mice. Br J Pharmacol (2005) 0.91
Characterization of chlortetracycline (aureomycin) as a calcium ionophore. Biochemistry (1982) 0.89
Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline. Neurobiol Dis (2006) 0.87
Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death. Neurobiol Dis (2005) 0.85
Impairment of mitochondrial function by minocycline. FEBS J (2009) 0.83
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline. Eur J Pharmacol (2004) 0.83
Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis. Biochem Biophys Res Commun (2005) 0.81
Inhibition of tumor angiogenesis. Ann N Y Acad Sci (1994) 0.81
Novobiocin forms cation-permeable ion channels in rat fetal distal lung epithelium. Am J Physiol (1993) 0.78
The properties of ion channels formed by the coumarin antibiotic, novobiocin, in lipid bilayers. Biochim Biophys Acta (1995) 0.78
Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci (2002) 1.92
Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones. J Neurochem (2011) 1.54
Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation. J Biol Chem (2006) 1.48
Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy. Crit Care Med (2011) 1.43
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol Med (2010) 1.27
Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import. Biophys J (2004) 1.24
Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology. J Exp Med (2004) 1.19
Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy. Neurotherapeutics (2010) 1.19
Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. J Biol Chem (2001) 1.13
Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons. J Neurosci Res (2006) 1.12
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry (2005) 1.08
Letter to the editor: μ-crystallin/CRYM functions as a ketimine-reducing enzyme and plays a role in thyroid hormone bioavailability due to strong inhibition/regulation by thyroid hormones. J Clin Endocrinol Metab (2015) 1.07
Transglutaminases and neurodegeneration. J Neurochem (2009) 1.03
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.01
Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency. Age (Dordr) (2008) 1.01
Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase. Arch Biochem Biophys (2008) 1.00
Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents. Amino Acids (2010) 0.98
Mechanism for the inhibition of transglutaminase 2 by cystamine. Biochem Pharmacol (2005) 0.98
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry (2005) 0.98
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. J Neurochem (2005) 0.97
Chemopreventive mechanisms of α-keto acid metabolites of naturally occurring organoselenium compounds. Amino Acids (2010) 0.96
Comparative kinetic analysis reveals that inducer-specific ion release precedes the mitochondrial permeability transition. Biochim Biophys Acta (2005) 0.96
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. Biochemistry (2006) 0.93
Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination. Biochimie (2009) 0.92
Increased levels of gamma-glutamylamines in Huntington disease CSF. J Neurochem (2008) 0.90
Lysine metabolism in mammalian brain: an update on the importance of recent discoveries. Amino Acids (2013) 0.90
Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.89
Urinary 2-hydroxy-5-oxoproline, the lactam form of α-ketoglutaramate, is markedly increased in urea cycle disorders. Anal Bioanal Chem (2011) 0.87
Modular drug transporters with diphtheria toxin translocation domain form edged holes in lipid membranes. J Control Release (2008) 0.87
The mitochondrial permeability transition as a target for neuroprotection. J Bioenerg Biomembr (2004) 0.87
Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases. Neurochem Res (2007) 0.87
Derivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplers. J Biol Chem (2011) 0.86
Novel photosensitizers trigger rapid death of malignant human cells and rodent tumor transplants via lipid photodamage and membrane permeabilization. PLoS One (2010) 0.86
Assay and purification of omega-amidase/Nit2, a ubiquitously expressed putative tumor suppressor, that catalyzes the deamidation of the alpha-keto acid analogues of glutamine and asparagine. Anal Biochem (2009) 0.86
Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives. J Nutr (2006) 0.86
The role of transglutaminases in neurodegenerative diseases: overview. Neurochem Int (2002) 0.86
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochem Res (2005) 0.86
Metabolism of the cysteine S-conjugate of busulfan involves a beta-lyase reaction. Drug Metab Dispos (2008) 0.85
Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. J Pharmacol Exp Ther (2008) 0.85
Novel mitochondria-targeted antioxidants: plastoquinone conjugated with cationic plant alkaloids berberine and palmatine. Pharm Res (2011) 0.84
Transglutaminases - possible drug targets in human diseases. Curr Drug Targets CNS Neurol Disord (2004) 0.83
Tuning the membrane surface potential for efficient toxin import. Proc Natl Acad Sci U S A (2002) 0.83
A GC/MS-based metabolomic approach for diagnosing citrin deficiency. Anal Bioanal Chem (2011) 0.83
N-terminally glutamate-substituted analogue of gramicidin A as protonophore and selective mitochondrial uncoupler. PLoS One (2012) 0.81
Methodology for use of mitochondria-targeted cations in the field of oxidative stress-related research. Methods Mol Biol (2015) 0.80
Spectrophotometric assays for L-lysine alpha-oxidase and gamma-glutamylamine cyclotransferase. Anal Biochem (2002) 0.79
Expression in Escherichia coli and purification of hexahistidine-tagged human tissue transglutaminase. Protein Expr Purif (2002) 0.79
Synthetic and natural polyanions induce cytochrome c release from mitochondria in vitro and in situ. Am J Physiol Cell Physiol (2011) 0.79
Penetrating cations enhance uncoupling activity of anionic protonophores in mitochondria. PLoS One (2013) 0.79
Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation. J Biol Chem (2012) 0.78
Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2. Acta Crystallogr D Biol Crystallogr (2013) 0.78
Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate. Comp Biochem Physiol B Biochem Mol Biol (2012) 0.78
From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D. Adv Nutr (2014) 0.78
Enzymatic analysis of α-ketoglutaramate--a biomarker for hyperammonemia. Talanta (2012) 0.77
New mechanistic explanation for the localization of ulcers in the rat duodenum: role of iron and selective uptake of cysteamine. Arch Biochem Biophys (2012) 0.77
Metabolism of cisplatin to a nephrotoxin. Toxicology (2008) 0.77
A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases. Adv Enzymol Relat Areas Mol Biol (2011) 0.77
Effect of liposomes on energy-dependent uptake of the antioxidant SkQR1 by isolated mitochondria. J Bioenerg Biomembr (2012) 0.77
A nonradioactive dot blot assay for transglutaminase activity. Anal Biochem (2009) 0.76
γ-Glutamylamines and neurodegenerative diseases. Amino Acids (2012) 0.76
New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase. Arch Biochem Biophys (2011) 0.76
Stable isotope gas chromatography-tandem mass spectrometry determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples. Anal Biochem (2012) 0.76
Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions. Neurochem Res (2015) 0.76
Food and Chemical Toxicology, 2011, 'Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity', R. Katayama, S. Nagata, H. Iida, N. Yamagishi, T. Yamashita, K. Furuhama. Food Chem Toxicol (2011) 0.75
Measurement of cysteine S-conjugate β-lyase activity. Curr Protoc Toxicol (2010) 0.75
Imine reductases: a comparison of glutamate dehydrogenase to ketimine reductases in the brain. Neurochem Res (2013) 0.75
Inhibition of human glutamine synthetase by L-methionine-S,R-sulfoximine-relevance to the treatment of neurological diseases. Metab Brain Dis (2013) 0.75
Comment on absorption of aminoethyl cysteine ketimine decarboxylated dimer in mice: effect on plasma antioxidant potential. J Agric Food Chem (2013) 0.75
Structure-(Dys)function relationships in mitochondrial electron transport chain complex II? Sci Aging Knowledge Environ (2003) 0.75
Histidine 440 controls the opening of colicin E1 channels in a lipid-dependent manner. Biochim Biophys Acta (2009) 0.75
Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons. Toxicol Sci (2016) 0.75