PubRank

Jochen Wiesner

Author PubWeight™ 46.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Microbial isoprenoid biosynthesis and human gammadelta T cell activation. FEBS Lett 2003 2.30
2 Fosmidomycin for malaria. Lancet 2002 2.03
3 RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc 2010 1.60
4 Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. J Am Chem Soc 2008 1.57
5 LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. FEBS Lett 2002 1.55
6 Fosmidomycin, a novel chemotherapeutic agent for malaria. Antimicrob Agents Chemother 2003 1.46
7 Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria. Antimicrob Agents Chemother 2006 1.35
8 Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children. J Infect Dis 2004 1.35
9 The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum. J Biol Chem 2004 1.31
10 Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Lett 2002 1.17
11 Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. J Biol Chem 2001 1.05
12 Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. PLoS One 2011 1.04
13 Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors. Bioorg Med Chem Lett 2006 1.03
14 Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates. Bioorg Med Chem 2007 1.00
15 Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum. FEBS Lett 2005 1.00
16 Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria. Antimicrob Agents Chemother 2005 0.99
17 Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 2002 0.98
18 Possible direct involvement of the active-site [4Fe-4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP. FEBS Lett 2006 0.97
19 Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes. J Am Chem Soc 2004 0.97
20 Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues. Arch Pharm (Weinheim) 2007 0.96
21 Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity. Bioorg Med Chem Lett 2003 0.94
22 Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity. Biol Lett 2011 0.94
23 Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions. J Am Chem Soc 2010 0.94
24 Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus. FEBS Lett 2010 0.94
25 Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro. Int J Parasitol 2006 0.93
26 Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. Chem Biodivers 2008 0.91
27 Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human gamma delta T cell activator. J Org Chem 2008 0.90
28 Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity. Arch Pharm (Weinheim) 2005 0.86
29 Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues. J Org Chem 2007 0.86
30 Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito. BMC Genomics 2013 0.86
31 Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors. Bioorg Med Chem Lett 2007 0.86
32 Antimalarial activity of n(6)-substituted adenosine derivatives (part 2). J Comb Chem 2002 0.85
33 Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection. Infect Immun 2008 0.85
34 Lucimycin, an antifungal peptide from the therapeutic maggot of the common green bottle fly Lucilia sericata. Biol Chem 2014 0.84
35 Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. J Med Chem 2006 0.82
36 Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase. ChemMedChem 2008 0.82
37 Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum. FEBS Lett 2013 0.81
38 Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I. Bioorg Med Chem 2002 0.81
39 Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction. Org Lett 2007 0.81
40 Methods to identify enzymes that degrade the main extracellular polysaccharide component of Staphylococcus epidermidis biofilms. Virulence 2013 0.80
41 Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity. Eur J Med Chem 2005 0.79
42 Determination of fosmidomycin in human serum and urine by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci 2004 0.78
43 Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials. ChemMedChem 2008 0.77
44 Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3. Bioorg Med Chem 2004 0.77
45 NMR studies of DOXP reductoisomerase and its inhibitor complex. Chembiochem 2011 0.75