Published in Blood on May 01, 1991
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci U S A (1996) 2.70
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67
Developmental and adult phenotyping directly from mutant embryonic stem cells. Proc Natl Acad Sci U S A (2007) 2.61
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc Natl Acad Sci U S A (1992) 2.22
Immune regulation by the ST6Gal sialyltransferase. Proc Natl Acad Sci U S A (1998) 2.08
Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. Am J Pathol (1995) 2.04
Theiler's virus infection: a model for multiple sclerosis. Clin Microbiol Rev (2004) 1.92
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med (1998) 1.88
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Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. Microbiol Rev (1995) 1.63
A primer on cytokines: sources, receptors, effects, and inducers. Clin Microbiol Rev (1997) 1.57
Inhibition of angiogenesis by interleukin 4. J Exp Med (1998) 1.53
Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc Natl Acad Sci U S A (1992) 1.48
Route and type of nutrition influence IgA-mediating intestinal cytokines. Ann Surg (1999) 1.38
Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement. EMBO J (1992) 1.35
Osteoporosis induced in mice by overproduction of interleukin 4. Proc Natl Acad Sci U S A (1993) 1.33
HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain. Mol Pain (2006) 1.32
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32
STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells. Neoplasia (2002) 1.32
Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions. Br J Cancer (2005) 1.31
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A (1993) 1.30
Involvement of cyclic AMP and nitric oxide in immunoglobulin E-dependent activation of Fc epsilon RII/CD23+ normal human keratinocytes. J Clin Invest (1994) 1.29
Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J Exp Med (1999) 1.29
A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain. Proc Natl Acad Sci U S A (1997) 1.28
Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity. Am J Pathol (1996) 1.26
PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc Natl Acad Sci U S A (1994) 1.24
In vivo modulation of vaccine-induced immune responses toward a Th1 phenotype increases potency and vaccine effectiveness in a herpes simplex virus type 2 mouse model. J Virol (1999) 1.23
T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol (2007) 1.20
Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis. Proc Natl Acad Sci U S A (1997) 1.18
Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors. Mol Cell Biol (2000) 1.15
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J Exp Med (1995) 1.14
Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation. EMBO J (1993) 1.14
Molecular aspects of regulation of collagen gene expression in fibrosis. J Clin Immunol (2005) 1.13
Enhanced interleukin-4 production in CD4+ T cells and elevated immunoglobulin E levels in antigen-primed mice by bisphenol A and nonylphenol, endocrine disruptors: involvement of nuclear factor-AT and Ca2+. Immunology (2003) 1.11
Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med (1994) 1.10
Gene expression profile in interleukin-4-stimulated human vascular endothelial cells. Mol Med (2004) 1.09
Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J Exp Med (1999) 1.08
Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis. J Exp Med (2000) 1.06
Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc Natl Acad Sci U S A (1995) 1.05
CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive. Immunology (2007) 1.04
Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema. J Physiol (2006) 1.03
Distribution and phenotype of Epstein-Barr virus-infected cells in inflammatory bowel disease. Am J Pathol (2000) 1.03
Interleukin 4 signals through two related pathways. Proc Natl Acad Sci U S A (1995) 1.02
Gene therapy and targeted toxins for glioma. Curr Gene Ther (2005) 1.02
Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4. Biochem J (1996) 1.02
Phage display selection of peptides that home to atherosclerotic plaques: IL-4 receptor as a candidate target in atherosclerosis. J Cell Mol Med (2008) 1.01
Asthma and the common cold: can viruses imitate worms? Thorax (1994) 1.01
Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun (2000) 1.00
Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter. Mol Cell Biol (2011) 1.00
Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM. J Biol Chem (2009) 0.99
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis. Arthritis Res (2001) 0.97
Effects of anti-IL-4 receptor monoclonal antibody on in vitro T cell cytokine levels: IL-4 production by T cells from non-atopic donors. Clin Exp Immunol (1998) 0.97
Gene therapy and targeted toxins for glioma. Curr Gene Ther (2011) 0.97
T helper 1 (Th1)/Th2 cytokine expression shift of peripheral blood CD4+ and CD8+ T cells in patients at the post-acute phase of stroke. Clin Exp Immunol (2008) 0.96
A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor. BMC Biol (2006) 0.95
Distinct lymphokine production by CD4+ T cells isolated from mucosal and systemic lymphoid organs. Immunology (1993) 0.95
The foreign body reaction in T-cell-deficient mice. J Biomed Mater Res A (2009) 0.94
Responsiveness of human neutrophils to interleukin-4: induction of cytoskeletal rearrangements, de novo protein synthesis and delay of apoptosis. Biochem J (1997) 0.94
Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy. Am J Pathol (2005) 0.94
The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome. Clin Exp Immunol (2001) 0.93
Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype. J Virol (2000) 0.92
Intestinal epithelial barrier dysfunction in food hypersensitivity. J Allergy (Cairo) (2011) 0.92
Nuclear factor of activated T cells is associated with a mast cell interleukin 4 transcription complex. Mol Cell Biol (1996) 0.91
T-cell lymphokine response to orally administered proteins during priming and unresponsiveness. Immunology (1993) 0.90
Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. J Virol (2010) 0.90
Interleukin-4 may contribute to the abundant T-cell reaction and paucity of neoplastic B cells in T-cell-rich B-cell lymphomas. Am J Pathol (1992) 0.90
The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis Inactivate the Th2 cytokines interleukin-4 and interleukin-5. Infect Immun (2009) 0.90
In situ detection of activated cytotoxic cells in follicular lymphomas. Am J Pathol (1994) 0.89
Quantitative assessment of IgG and IgA subclass producing cells in rectal mucosa during shigellosis. J Clin Pathol (1997) 0.89
Role of direct estrogen receptor signaling in wear particle-induced osteolysis. Biomaterials (2012) 0.89
Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6. Proc Natl Acad Sci U S A (1998) 0.89
Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite. Infect Immun (2001) 0.88
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor. Proc Natl Acad Sci U S A (1994) 0.88
Probabilistic regulation of IL-4 production. J Clin Immunol (2005) 0.88
Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections--a phase I dose toxicity trial. Br J Cancer (1992) 0.87
IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line. Immunology (1995) 0.87
Identification of a cDNA for a human high-molecular-weight B-cell growth factor. Proc Natl Acad Sci U S A (1993) 0.86
Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells. J Clin Pathol (1995) 0.86
Distinct immunoregulatory cytokine pattern in Egyptian patients with occult Hepatitis C infection and unexplained persistently elevated liver transaminases. Asian J Transfus Sci (2012) 0.86
MHC class II transactivator represses human IL-4 gene transcription by interruption of promoter binding with CBP/p300, STAT6 and NFAT1 via histone hypoacetylation. Immunology (2007) 0.86
IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes. J Exp Med (1994) 0.85
Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells. J Immunol (2009) 0.82
Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13. Clin Exp Immunol (1995) 0.82
Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis. Biomol Ther (Seoul) (2010) 0.82
Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria. Mol Med (1997) 0.81
Phase I trial of continuous infusion recombinant human interleukin-4 in patients with cancer. Invest New Drugs (2004) 0.81
Dendritic cell-derived nitric oxide is involved in IL-4-induced suppression of experimental allergic encephalomyelitis (EAE) in Lewis rats. Clin Exp Immunol (1999) 0.81
Inhibition by interleukin-4 of constitutive beta interferon synthesis in mouse macrophages. J Virol (1994) 0.81
Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium. Cytokine (2009) 0.81
Haplotype diversity in the interleukin-4 gene is not associated with HIV-1 transmission and AIDS progression. Immunogenetics (2003) 0.81
Role of peptide antigen for induction of inhibitory antibodies to Streptococcus mutans in human oral cavity. Clin Exp Immunol (2004) 0.81
Helicobacter pylori cag pathogenicity island is associated with reduced expression of interleukin-4 (IL-4) mRNA and modulation of the IL-4delta2 mRNA isoform in human gastric mucosa. Infect Immun (2003) 0.81
Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124). Br J Cancer (1996) 0.81
Hydroquinone, a reactive metabolite of benzene, enhances interleukin-4 production in CD4+ T cells and increases immunoglobulin E levels in antigen-primed mice. Immunology (2002) 0.81
Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes. J Exp Med (1997) 0.80
IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblasts. Inflammation (2004) 0.80
B-cell activation and the one B cell/one antibody paradigm. Immunol Rev (1990) 0.75