Published in J Mol Cell Cardiol on February 25, 2010
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2011) 1.58
The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure. J Mol Cell Cardiol (2010) 1.22
C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting. EMBO J (2011) 1.19
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1. Nat Struct Mol Biol (2013) 1.01
p38 MAPK in cardioprotection - are we there yet? Br J Pharmacol (2014) 0.90
TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α. Mol Cancer Res (2012) 0.90
p38β MAPK upregulates atrogin1/MAFbx by specific phosphorylation of C/EBPβ. Skelet Muscle (2012) 0.88
Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation. J Transplant (2012) 0.86
Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point. Drug Discov Today Dis Mech (2010) 0.82
Role of p38 inhibition in cardiac ischemia/reperfusion injury. Eur J Clin Pharmacol (2011) 0.81
Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Biochim Biophys Acta (2013) 0.79
Oxygen surrounding the heart during ischemic conservation determines the myocardial injury during reperfusion. Am J Cardiovasc Dis (2015) 0.77
Profiling of cell stress protein expression in cardiac tissue of cardiosurgical patients undergoing remote ischemic preconditioning: implications for thioredoxin in cardioprotection. J Transl Med (2015) 0.76
Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase. J Cachexia Sarcopenia Muscle (2016) 0.75
Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line. Cytotechnology (2017) 0.75
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem (1998) 3.80
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc Natl Acad Sci U S A (2003) 2.75
The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol (2006) 2.68
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J Biol Chem (2004) 2.24
Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol (2005) 2.19
Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580. FEBS Lett (1999) 2.05
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. J Biol Chem (2004) 1.20
The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. FASEB J (2000) 1.20
Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation. J Biol Chem (2007) 1.20
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease. Pharmacol Ther (2007) 1.10
Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion. Biochem Biophys Res Commun (2003) 1.05
Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? J Mol Cell Cardiol (2008) 0.96
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580. J Biol Chem (2009) 0.96
Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart. Circ Res (2001) 0.93
Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase. Circ Res (2001) 0.88
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J (2003) 3.29
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol (2002) 3.17
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J (2003) 2.74
Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res (2002) 2.73
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity (2005) 2.56
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol (2008) 2.37
The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol (2008) 2.34
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol (2006) 2.21
Late intervention after anterior myocardial infarction: effects on left ventricular size, function, quality of life, and exercise tolerance: results of the Open Artery Trial (TOAT Study). J Am Coll Cardiol (2002) 2.19
Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol (2005) 2.19
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J (2004) 2.11
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A (2013) 1.97
Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins. Biochem J (2010) 1.94
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol (2006) 1.89
Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? Basic Res Cardiol (2011) 1.81
Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. Am J Physiol Heart Circ Physiol (2007) 1.77
MSK1 activity is controlled by multiple phosphorylation sites. Biochem J (2005) 1.72
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol (2006) 1.72
Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase. Cardiovasc Res (2006) 1.64
The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol (2008) 1.61
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2011) 1.58
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol (2007) 1.53
Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury. Basic Res Cardiol (2015) 1.52
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A (2012) 1.52
Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse. Circ Res (2008) 1.44
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med (2011) 1.42
MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling. Biochem J (2005) 1.42
m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol (2006) 1.37
Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol (2003) 1.36
Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β. J Biol Chem (2011) 1.35
PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol (2012) 1.35
C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J (2006) 1.35
Thymosin beta4 facilitates epicardial neovascularization of the injured adult heart. Ann N Y Acad Sci (2010) 1.33
Regulation of miRNA transcription in macrophages in response to Candida albicans. PLoS One (2010) 1.33
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. J Biol Chem (2009) 1.30
CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal (2006) 1.29
Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol (2004) 1.28
Bioactivity and pharmacological actions of carbon monoxide-releasing molecules. Curr Pharm Des (2003) 1.27
Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men. Arterioscler Thromb Vasc Biol (2007) 1.24
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23
Metal carbonyls: a new class of pharmaceuticals? Angew Chem Int Ed Engl (2003) 1.19
Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imaging (2012) 1.18
Identification of cardiac myosin-binding protein C as a candidate biomarker of myocardial infarction by proteomics analysis. Mol Cell Proteomics (2009) 1.18
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. Nat Struct Biol (2003) 1.16
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J (2008) 1.15
Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol (2012) 1.15
Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent. Nat Med (2011) 1.13
Future treatment strategies in ST-segment elevation myocardial infarction. Lancet (2013) 1.12
Targeting p38-MAPK in the ischaemic heart: kill or cure? Curr Opin Pharmacol (2008) 1.11
Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide. J Biol Chem (2006) 1.11
New therapeutic targets in cardiology: p38 alpha mitogen-activated protein kinase for ischemic heart disease. Circulation (2012) 1.11
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease. Pharmacol Ther (2007) 1.10
p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res (2009) 1.10
Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Coll Cardiol (2002) 1.10
Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support. Circulation (2004) 1.09
Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res (2002) 1.09
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. Proc Natl Acad Sci U S A (2012) 1.08
A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J (2004) 1.08
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. Biochem J (2007) 1.07
MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages. Biochem J (2010) 1.06
Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS One (2013) 1.06
miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One (2013) 1.06
Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1. J Neurochem (2007) 1.05
Waist-hip ratio and low HDL predict the risk of coronary artery disease in Pakistanis. Curr Med Res Opin (2004) 1.05
Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease. J Cardiovasc Magn Reson (2012) 1.05
Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J (2006) 1.05
The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells. BMC Mol Biol (2003) 1.03
IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc Res (2005) 1.02
Short bowel syndrome: clinical guidelines for nutrition management. Nutr Clin Pract (2005) 1.01
Systemic inflammation in unstable angina is the result of myocardial necrosis. J Am Coll Cardiol (2002) 1.00
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system. Biochem J (2012) 1.00
Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J (2012) 1.00
Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo. Basic Res Cardiol (2002) 1.00
The microbiota and its metabolites in colonic mucosal health and cancer risk. Nutr Clin Pract (2012) 0.99
Remote ischaemic preconditioning in coronary artery bypass surgery: a meta-analysis. Heart (2012) 0.99
Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol (2013) 0.99
Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects. Atherosclerosis (2008) 0.98
Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon. Am J Physiol Heart Circ Physiol (2006) 0.97
CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling. Biochem J (2014) 0.96
Evaluation of approaches to generation of tissue-specific knock-in mice. J Biol Chem (2006) 0.96
The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem (2008) 0.96
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580. J Biol Chem (2009) 0.96
Generation of a conditional CREB Ser133Ala knockin mouse. Genesis (2009) 0.95
p38 MAP kinase inhibitors. Part 5: discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold. Bioorg Med Chem Lett (2006) 0.94