Helmut Klocker

Author PubWeight™ 113.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The relationship between prostate-specific antigen and prostate cancer risk: the Prostate Biopsy Collaborative Group. Clin Cancer Res 2010 2.87
2 Tyrol Prostate Cancer Demonstration Project: early detection, treatment, outcome, incidence and mortality. BJU Int 2008 2.60
3 Prostate-specific antigen (PSA) isoform p2PSA in combination with total PSA and free PSA improves diagnostic accuracy in prostate cancer detection. Eur Urol 2010 2.47
4 Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy. Proc Natl Acad Sci U S A 2009 2.33
5 Expression and prognostic relevance of annexin A3 in prostate cancer. Eur Urol 2008 2.32
6 Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics 2011 2.24
7 Large-scale study of clinical impact of PSA velocity: long-term PSA kinetics as method of differentiating men with from those without prostate cancer. Urology 2007 1.69
8 Longitudinal PSA changes in men with and without prostate cancer: assessment of prostate cancer risk. Prostate 2005 1.68
9 Annexin A3 in urine: a highly specific noninvasive marker for prostate cancer early detection. J Urol 2008 1.68
10 Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J Steroid Biochem Mol Biol 2005 1.67
11 Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients. Am J Hum Genet 2010 1.67
12 Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients. Cancer Res 2005 1.62
13 Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205. Am J Pathol 2012 1.48
14 Proenzyme psa for the early detection of prostate cancer in the 2.5-4.0 ng/ml total psa range: preliminary analysis. Urology 2003 1.46
15 Serum pro-prostate specific antigen preferentially detects aggressive prostate cancers in men with 2 to 4 ng/ml prostate specific antigen. J Urol 2004 1.44
16 Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative Group. World J Urol 2011 1.42
17 Serum pro prostate specific antigen improves cancer detection compared to free and complexed prostate specific antigen in men with prostate specific antigen 2 to 4 ng/ml. J Urol 2003 1.40
18 hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis. Cancer Res 2006 1.33
19 The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. J Exp Ther Oncol 2004 1.32
20 Plexin-B1 mutations in prostate cancer. Proc Natl Acad Sci U S A 2007 1.28
21 The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. J Mol Med (Berl) 2012 1.23
22 Reduction of prostate cancer mortality in Tyrol, Austria, after introduction of prostate-specific antigen testing. Am J Epidemiol 2006 1.21
23 Targeting the insulin-like growth factor network in cancer therapy. Cancer Biol Ther 2011 1.21
24 Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours. J Steroid Biochem Mol Biol 2006 1.19
25 Modulated expression of WFDC1 during carcinogenesis and cellular senescence. Carcinogenesis 2008 1.13
26 Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. Prostate 2005 1.12
27 The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection. Prostate 2010 1.10
28 Genetic alterations in the PI3K pathway in prostate cancer. Anticancer Res 2009 1.09
29 Androgen receptors in prostate cancer. J Urol 2003 1.07
30 The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor. Mol Cell Biol 2003 1.07
31 Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells. Prostate 2004 1.06
32 Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. Carcinogenesis 2012 1.06
33 The expression of transcription factor activating transcription factor 3 in the human prostate and its regulation by androgen in prostate cancer. J Urol 2006 1.05
34 Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer. Cancer Res 2005 1.04
35 Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1. Carcinogenesis 2009 1.03
36 Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer. Mol Cancer 2009 1.02
37 PIAS1 is increased in human prostate cancer and enhances proliferation through inhibition of p21. Am J Pathol 2012 1.02
38 Molecular effects of the isoflavonoid genistein in prostate cancer. Clin Prostate Cancer 2005 1.01
39 Proteomics profiling of microdissected low- and high-grade prostate tumors identifies Lamin A as a discriminatory biomarker. J Proteome Res 2010 1.00
40 Importance of prostate volume in the European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators: results from the prostate biopsy collaborative group. World J Urol 2011 1.00
41 Novel therapeutic approaches for the treatment of castration-resistant prostate cancer. J Steroid Biochem Mol Biol 2013 0.99
42 Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia. Prostate 2003 0.99
43 Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility. Endocr Relat Cancer 2009 0.99
44 Prostate-specific antigen testing in Tyrol, Austria: prostate cancer mortality reduction was supported by an update with mortality data up to 2008. Int J Public Health 2011 0.96
45 Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2010 0.96
46 Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor. Cancer Gene Ther 2002 0.95
47 The transcriptional co-activator cAMP response element-binding protein-binding protein is expressed in prostate cancer and enhances androgen- and anti-androgen-induced androgen receptor function. Am J Pathol 2003 0.95
48 Evaluating the Prostate Cancer Prevention Trial High Grade Prostate Cancer Risk Calculator in 10 international biopsy cohorts: results from the Prostate Biopsy Collaborative Group. World J Urol 2012 0.94
49 Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells. Endocrinology 2012 0.94
50 Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians. PLoS One 2009 0.94
51 Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells. FEBS J 2013 0.94
52 A new rule-based algorithm for identifying metabolic markers in prostate cancer using tandem mass spectrometry. Bioinformatics 2008 0.93
53 Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells. Mol Endocrinol 2012 0.93
54 High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. Mod Pathol 2012 0.93
55 Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor beta. Eur Urol 2004 0.93
56 Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk. Proc Natl Acad Sci U S A 2012 0.91
57 Stromal insulin-like growth factor binding protein 3 (IGFBP3) is elevated in the diseased human prostate and promotes ex vivo fibroblast-to-myofibroblast differentiation. Endocrinology 2013 0.91
58 Accumulation of mutations over the entire mitochondrial genome of breast cancer cells obtained by tissue microdissection. Breast Cancer Res Treat 2010 0.91
59 Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias. BJU Int 2013 0.90
60 Clinical and pathologic features of prostate cancer detected after repeat false-negative biopsy in a screening population. Prostate 2004 0.90
61 Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3. Proteomics 2007 0.89
62 In vitro model systems to study androgen receptor signaling in prostate cancer. Endocr Relat Cancer 2013 0.89
63 SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer. Endocr Relat Cancer 2014 0.89
64 Insulin-like growth factor binding protein-3 (IGFBP-3) in the prostate and in prostate cancer: local production, distribution and secretion pattern indicate a role in stromal-epithelial interaction. Prostate 2008 0.89
65 Serum-autoantibodies for discovery of prostate cancer specific biomarkers. Prostate 2011 0.88
66 Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC Cancer 2013 0.88
67 Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy. Int J Cancer 2010 0.88
68 Characterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y. PLoS One 2013 0.88
69 Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis. Oncotarget 2014 0.88
70 Screening for prostate cancer: updated experience from the Tyrol study. Can J Urol 2005 0.88
71 Expression of the IGF axis is decreased in local prostate cancer but enhanced after benign prostate epithelial differentiation and TGF-β treatment. Am J Pathol 2011 0.87
72 Identification of genes involved in estrogenic action in the human prostate using microarray analysis. Genomics 2004 0.86
73 Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats. Asian J Androl 2009 0.86
74 Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target? Prostate 2013 0.85
75 Epithelial-to-mesenchymal transition and estrogen receptor α mediated epithelial dedifferentiation mark the development of benign prostatic hyperplasia. Prostate 2014 0.85
76 Real-time quantitative RT-PCR assay of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood for detection of prostate cancer micrometastasis. Urol Oncol 2008 0.85
77 Microsatellite alterations in human bladder cancer: detection of tumor cells in urine sediment and tumor tissue. Eur Urol 2002 0.85
78 Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase expression in prostatic stromal cells via prostaglandin E2. J Endocrinol 2007 0.84
79 Genetic aberrations in prostate carcinoma detected by comparative genomic hybridization and microsatellite analysis: association with progression and angiogenesis. Prostate 2004 0.84
80 Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A. Int J Cancer 2010 0.84
81 Targeting the androgen receptor in hormone-refractory prostate cancer--new concepts. Future Oncol 2005 0.84
82 Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP prostate cancer cells. Urology 2011 0.83
83 Human kallikrein 7 induces epithelial-mesenchymal transition-like changes in prostate carcinoma cells: a role in prostate cancer invasion and progression. Anticancer Res 2010 0.82
84 Screening with low PSA cutoff values results in low rates of positive surgical margins in radical prostatectomy specimens. Prostate 2002 0.81
85 MALDI-MS tissue imaging identification of biliverdin reductase B overexpression in prostate cancer. J Proteomics 2013 0.81
86 Impact of age on complexed PSA levels in men with total PSA levels of up to 20 ng/mL. Urology 2003 0.81
87 Insulin-like growth factor-binding protein-5 enters vesicular structures but not the nucleus. Traffic 2007 0.81
88 Adverse pathological findings in needle biopsy gleason score 6 prostate cancers with low and intermediate preoperative PSA levels following radical prostatectomy. Anticancer Res 2012 0.81
89 Gene expression changes following androgen receptor elimination in LNCaP prostate cancer cells. Mol Carcinog 2003 0.81
90 A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling. Mol Cancer 2014 0.80
91 Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055. Phytomedicine 2013 0.79
92 Estrogens and aspects of prostate disease. Int J Urol 2007 0.79
93 Elevated levels of Dickkopf-related protein 3 in seminal plasma of prostate cancer patients. J Transl Med 2011 0.79
94 Gene therapy strategies in prostate cancer. Curr Gene Ther 2005 0.79
95 Influence of blood sampling on protein profiling and pattern analysis using matrix-assisted laser desorption/ionisation mass spectrometry. BJU Int 2007 0.79
96 Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro. J Urol 2004 0.79
97 Characterization of normal and malignant prostate tissue by Fourier transform infrared microspectroscopy. Mol Biosyst 2010 0.78
98 Estrogen receptor-related receptor alpha mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells. Mol Endocrinol 2010 0.78
99 Measurement of intracellular versus extracellular prostate-specific antigen levels in peripheral macrophages: a new approach to noninvasive diagnosis of prostate cancer. Clin Prostate Cancer 2004 0.78
100 Material-enhanced laser desorption/ionization (MELDI)--a new protein profiling tool utilizing specific carrier materials for time of flight mass spectrometric analysis. J Am Soc Mass Spectrom 2006 0.78
101 Studies on androgen receptor mutations and amplification in human prostate cancer. Methods Mol Med 2003 0.78
102 Derivatized cellulose combined with MALDI-TOF MS: a new tool for serum protein profiling. J Proteome Res 2005 0.77
103 Is real-time PCR the correct method to evaluate the incidence of human papillomavirus in prepuces of asymptomatic boys and men? World J Urol 2013 0.77
104 Prostaglandin E2 induces stromal cell-derived factor-1 expression in prostate stromal cells by activating protein kinase A and transcription factor Sp1. Int J Biochem Cell Biol 2012 0.76
105 Development of a cell-isolation method for human prostatic smooth muscle cells based on cell type-specific activation of the SM22 gene promoter. BJU Int 2006 0.75
106 Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type iα of protein kinase a in vivo. Int J Mol Sci 2013 0.75
107 Ability of PSA-positive circulating macrophages to detect prostate cancer. Prostate 2005 0.75
108 Clinically insignificant improvement of prostate cancer prediction by addition of sex steroid hormones and SHBG serum levels to serum PSA, fPSA%, and age in a screening setting. Horm Mol Biol Clin Investig 2012 0.75
109 Screening for prostate cancer: updated experience from the Tyrol study. Curr Urol Rep 2004 0.75
110 Patient-reported urinary incontinence and erectile dysfunction following radical prostatectomy: results from the European Prostate Centre Innsbruck. Urol Int 2015 0.75
111 Curbing tobacco's toll starts with the professionals: World No Tobacco Day. Lancet 2005 0.75
112 PGE2 modulates the transcriptional activity of ERRa in prostate stromal cells. Endocrine 2014 0.75