Michel Sadelain

Author PubWeight™ 190.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 2009 13.16
2 CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 2013 7.99
3 Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 2011 7.49
4 Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 2009 7.04
5 Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med 2003 6.81
6 Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 2014 5.60
7 Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor. Nat Biotechnol 2002 5.49
8 Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther 2010 4.54
9 Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res 2007 4.42
10 Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nat Biotechnol 2012 3.28
11 Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J Immunother 2009 3.11
12 T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med 2007 3.07
13 Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 2012 2.86
14 Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A 2009 2.86
15 CARs on track in the clinic. Mol Ther 2011 2.86
16 Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A 2010 2.67
17 Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol Ther 2009 2.52
18 Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol 2010 2.43
19 A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity. J Immunol 2009 2.43
20 miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells. Cell Stem Cell 2011 2.33
21 Occurrence of leukaemia following gene therapy of X-linked SCID. Nat Rev Cancer 2003 2.08
22 Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase. Nat Med 2009 1.98
23 T-cell therapy at the threshold. Nat Biotechnol 2012 1.91
24 A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. Blood 2002 1.89
25 Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood 2012 1.87
26 Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nat Biotechnol 2003 1.87
27 PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci Transl Med 2013 1.76
28 A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cells. Stem Cells 2010 1.73
29 Targeted elimination of prostate cancer by genetically directed human T lymphocytes. Cancer Res 2005 1.67
30 How do CARs work?: Early insights from recent clinical studies targeting CD19. Oncoimmunology 2012 1.66
31 Multifactorial optimization of gammaretroviral gene transfer into human T lymphocytes for clinical application. Hum Gene Ther 2007 1.62
32 Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain. Nat Biotechnol 2005 1.54
33 Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence. J Clin Oncol 2012 1.50
34 In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Cancer Res 2011 1.48
35 Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial. Clin Cancer Res 2003 1.43
36 Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nat Biotechnol 2013 1.39
37 Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging. J Nucl Med 2008 1.35
38 A method to sequence and quantify DNA integration for monitoring outcome in gene therapy. Nucleic Acids Res 2011 1.33
39 Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene. Blood 2002 1.29
40 IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood 2010 1.29
41 American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells. Mol Ther 2003 1.29
42 The ABCs of artificial antigen presentation. Nat Biotechnol 2004 1.29
43 A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference. Nat Biotechnol 2005 1.28
44 CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems. Vaccine 2004 1.25
45 Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res 2012 1.25
46 Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol 2008 1.24
47 Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells. Proc Natl Acad Sci U S A 2005 1.24
48 CAR therapy: the CD19 paradigm. J Clin Invest 2015 1.20
49 CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. PLoS One 2013 1.19
50 Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J Clin Invest 2016 1.18
51 Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras. J Clin Invest 2008 1.16
52 Stem cell-derived erythroid cells mediate long-term systemic protein delivery. Nat Biotechnol 2006 1.16
53 Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma. Clin Cancer Res 2013 1.16
54 In vivo imaging and quantitation of adoptively transferred human antigen-specific T cells transduced to express a human norepinephrine transporter gene. Cancer Res 2007 1.15
55 The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the ltr, and the promise of lineage-restricted vectors. Mol Ther 2007 1.13
56 Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients. Cancer Immunol Immunother 2011 1.12
57 Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras. Oncogene 2002 1.12
58 Hematopoietic stem cell engineering at a crossroads. Blood 2011 1.10
59 Induction of autoantibodies to syngeneic prostate-specific membrane antigen by xenogeneic vaccination. Int J Cancer 2005 1.07
60 The potential of stem cells as an in vitro source of red blood cells for transfusion. Cell Stem Cell 2012 1.06
61 Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts. Cancer Res 2002 1.03
62 Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model. Exp Hematol 2006 1.03
63 Gene therapy through autologous transplantation of gene-modified hematopoietic stem cells. Biol Blood Marrow Transplant 2012 1.02
64 Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo. Blood 2010 1.01
65 Prostate-specific membrane antigen retargeted measles virotherapy for the treatment of prostate cancer. Prostate 2009 1.00
66 A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. J Nucl Med 2010 1.00
67 Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector. Nat Protoc 2011 0.99
68 Safe mobilization of CD34+ cells in adults with β-thalassemia and validation of effective globin gene transfer for clinical investigation. Blood 2014 0.97
69 High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration. J Virol 2013 0.97
70 Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele. Blood 2003 0.97
71 A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy. J Immunol 2009 0.97
72 Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. J Clin Invest 2013 0.96
73 Ligand binding to inhibitory killer cell Ig-like receptors induce colocalization with Src homology domain 2-containing protein tyrosine phosphatase 1 and interruption of ongoing activation signals. J Immunol 2004 0.95
74 Retroviral transduction of murine primary T lymphocytes. Methods Mol Biol 2009 0.94
75 Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in beta-thalassemic mice. Blood 2007 0.94
76 [131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity. Eur J Nucl Med Mol Imaging 2006 0.94
77 Benefits of utilizing gene-modified iPSCs for clinical applications. Cell Stem Cell 2010 0.92
78 Artificial antigen-presenting cells transduced with telomerase efficiently expand epitope-specific, human leukocyte antigen-restricted cytotoxic T cells. Cancer Res 2005 0.90
79 Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma. Cancer Immunol Immunother 2011 0.90
80 An in vivo platform for tumor biomarker assessment. PLoS One 2011 0.89
81 Current status of globin gene therapy for the treatment of beta-thalassaemia. Br J Haematol 2008 0.88
82 Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One 2013 0.87
83 Erythroid-specific human factor IX delivery from in vivo selected hematopoietic stem cells following nonmyeloablative conditioning in hemophilia B mice. Mol Ther 2008 0.87
84 Animal models and molecular imaging tools to investigate lymph node metastases. J Mol Med (Berl) 2011 0.87
85 Large-scale clinical-grade retroviral vector production in a fixed-bed bioreactor. J Immunother 2015 0.85
86 Fetal gene therapy of alpha-thalassemia in a mouse model. Proc Natl Acad Sci U S A 2007 0.85
87 Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization. J Immunol 2006 0.84
88 Langerhans cells derived from genetically modified human CD34+ hemopoietic progenitors are more potent than peptide-pulsed Langerhans cells for inducing antigen-specific CD8+ cytolytic T lymphocyte responses. J Immunol 2005 0.83
89 Novel approaches to enhance the specificity and safety of engineered T cells. Cancer J 2014 0.83
90 Therapeutic globin gene delivery using lentiviral vectors. Curr Opin Mol Ther 2002 0.83
91 Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rγ mice. Stem Cells Int 2011 0.82
92 Derivation of genetically modified human pluripotent stem cells with integrated transgenes at unique mapped genomic sites. Nat Protoc 2011 0.81
93 Functional assessment of the engraftment potential of gammaretrovirus-modified CD34+ cells, using a short serum-free transduction protocol. Hum Gene Ther 2006 0.81
94 Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. Neoplasia 2013 0.81
95 Frequency of missense mutations in the coding region of a eukaryotic gene transferred by retroviral vectors. J Virol 2002 0.80
96 Transient in vivo beta-globin production after lentiviral gene transfer to hematopoietic stem cells in the nonhuman primate. Hum Gene Ther 2009 0.80
97 Novel strategies for cancer therapy: the potential of genetically modified T lymphocytes. Curr Hematol Rep 2004 0.79
98 Fulminant experimental autoimmune encephalo-myelitis induced by retrovirally mediated TCR gene transfer. Eur J Immunol 2005 0.79
99 Development of a new reporter gene system--dsRed/xanthine phosphoribosyltransferase-xanthine for molecular imaging of processes behind the intact blood-brain barrier. Mol Imaging 2003 0.79
100 T cell activation upon exposure to patient-derived tumor tissue: a functional assay to select patients for adoptive T cell therapy. J Immunol Methods 2010 0.79
101 Gene therapy for homozygous beta-thalassemia. Is it a reality? Hemoglobin 2009 0.78
102 Production of clinical-grade plasmid DNA for human Phase I clinical trials and large animal clinical studies. Vaccine 2007 0.78
103 PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer Res 2013 0.78
104 Tolerance induction by allogeneic hematopoietic stem cells. Cell Stem Cell 2011 0.78
105 Eliminating cells gone astray. N Engl J Med 2011 0.78
106 CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models. Biochem Biophys Res Commun 2013 0.77
107 Highly divergent integration profile of adeno-associated virus serotype 5 revealed by high-throughput sequencing. J Virol 2013 0.77
108 Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints. Virol J 2014 0.77
109 Towards the genetic treatment of beta-thalassemia: new disease models, new vectors, new cells. Haematologica 2008 0.77
110 The need for genetically engineering therapeutic pluripotent stem cells. Mol Ther 2010 0.77
111 Reconstructing blood from induced pluripotent stem cells. F1000 Med Rep 2010 0.77
112 Langerhans-type dendritic cells genetically modified to express full-length antigen optimally stimulate CTLs in a CD4-dependent manner. J Immunol 2006 0.76
113 A New Induction to the Gene and Cell Therapy Hall Of Fame: Genome Editing. Mol Ther 2016 0.75
114 Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia. J Clin Invest 2016 0.75
115 A "vector drain" in US gene therapy development? Mol Ther 2008 0.75
116 Somatic cell engineering and the immunotherapy of leukemias and lymphomas. Adv Pharmacol 2004 0.75
117 Scalable expansion of potent genetically modified human langerhans cells in a closed system for clinical applications. J Immunother 2007 0.75
118 The meaning of translation. Cancer Invest 2006 0.75
119 Genetic strategies for the treatment of sickle cell anaemia. Br J Haematol 2011 0.75