Upregulation of Salmonella-induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor: involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 2828125)

Published in Mediators Inflamm on February 24, 2010

Authors

Fu-Chen Huang1

Author Affiliations

1: Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao-sung Hsiang, Kaohsiung Hsien 833, Taiwan. huang817@adm.cgmh.org.tw

Articles cited by this

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest (1995) 7.68

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol (1990) 6.57

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest (1998) 4.77

The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med (1998) 3.16

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med (2001) 2.91

Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest (1993) 2.79

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J (1999) 2.75

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation. Biol Chem (1999) 2.06

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model. Infect Immun (1993) 1.77

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem Pharmacol (2000) 1.71

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. J Exp Med (1997) 1.47

Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid. J Invest Dermatol (2004) 1.35

Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J Biol Chem (2005) 1.33

Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit Care Med (2002) 1.32

A gene-expression program reflecting the innate immune response of cultured intestinal epithelial cells to infection by Listeria monocytogenes. Genome Biol (2002) 1.31

Physical shock wave mediates membrane hyperpolarization and Ras activation for osteogenesis in human bone marrow stromal cells. Biochem Biophys Res Commun (2001) 1.26

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res (2001) 1.22

Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase. Biochem J (2000) 1.18

Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut (2008) 1.16

Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Gastroenterology (1999) 1.15

Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations. J Biol Chem (2007) 1.10

IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B. J Surg Res (1997) 1.10

Intestinal mucosal responses to microbial infection. Springer Semin Immunopathol (2005) 1.10

Obstructive jaundice impairs reticuloendothelial function and promotes bacterial translocation in the rat. J Surg Res (1994) 1.08

Regulatory effects of interleukin-6 in immunoglobulin G immune-complex-induced lung injury. Am J Pathol (1997) 1.07

Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. Am J Physiol Gastrointest Liver Physiol (2000) 1.06

Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells. Mol Pharmacol (2005) 1.05

Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Infect Immun (2004) 1.02

Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis. Immunology (2004) 1.00

Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells. Am J Physiol Regul Integr Comp Physiol (2002) 0.97

Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. Mol Med (2002) 0.96

A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells. FEMS Microbiol Lett (2005) 0.93

The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts. J Pharmacol Exp Ther (2005) 0.89

Local administration of the Poly ADP-Ribose Polymerase (PARP) inhibitor, PJ34 during hindlimb ischemia modulates skeletal muscle reperfusion injury. J Surg Res (2006) 0.89

PARP inhibition reduces acute colonic inflammation in rats. Eur J Pharmacol (2007) 0.88

Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism. Am J Physiol Regul Integr Comp Physiol (2007) 0.85

Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. J Surg Res (1998) 0.82

GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat. Biochem Pharmacol (2002) 0.82

Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice. Clin Sci (Lond) (2000) 0.81

Role of mitogen-activated protein kinases in the iNOS production and cytokine secretion by Salmonella enterica serovar Typhimurium porins. Cytokine (2008) 0.81

Poly(adp-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge. Shock (2001) 0.77