PubRank

Xian-Zheng Zhang

Author PubWeight™ 89.29‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Injectable hydrogel helps bone marrow-derived mononuclear cells restore infarcted myocardium. Cardiology 2010 1.47
2 Novel thermosensitive hydrogel injection inhibits post-infarct ventricle remodelling. Eur J Heart Fail 2009 1.06
3 Injection of a novel synthetic hydrogel preserves left ventricle function after myocardial infarction. J Biomed Mater Res A 2009 1.00
4 Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery. J Am Chem Soc 2013 0.98
5 Low molecular weight polyethylenimine grafted N-maleated chitosan for gene delivery: properties and in vitro transfection studies. Biomacromolecules 2008 0.97
6 Bone marrow stem cells implantation with alpha-cyclodextrin/MPEG-PCL-MPEG hydrogel improves cardiac function after myocardial infarction. Acta Biomater 2009 0.94
7 Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate). Biomaterials 2005 0.92
8 Targeted gene delivery mediated by folate-polyethylenimine-block-poly(ethylene glycol) with receptor selectivity. Bioconjug Chem 2009 0.90
9 Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems. Int J Pharm 2008 0.90
10 Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property. Colloids Surf B Biointerfaces 2008 0.89
11 The influence of RGD addition on the gene transfer characteristics of disulfide-containing polyethyleneimine/DNA complexes. Biomaterials 2008 0.88
12 Novel stimuli-responsive micelle self-assembled from Y-shaped P(UA-Y-NIPAAm) copolymer for drug delivery. Biomacromolecules 2006 0.88
13 Biodegradable and pH-sensitive hydrogels for cell encapsulation and controlled drug release. Biomacromolecules 2008 0.88
14 Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei. J Control Release 2010 0.88
15 Toward the development of partially biodegradable and injectable thermoresponsive hydrogels for potential biomedical applications. ACS Appl Mater Interfaces 2009 0.87
16 Self-assembled terplexes for targeted gene delivery with improved transfection. Bioconjug Chem 2010 0.86
17 Effect of the molecular weight of polyethylene glycol (PEG) on the properties of chitosan-PEG-poly(N-isopropylacrylamide) hydrogels. J Mater Sci Mater Med 2008 0.86
18 Hybrid nanospheres and vesicles based on pectin as drug carriers. Langmuir 2009 0.85
19 Encapsulation of an adamantane-doxorubicin prodrug in pH-responsive polysaccharide capsules for controlled release. ACS Appl Mater Interfaces 2012 0.85
20 Graphene-based anticancer nanosystem and its biosafety evaluation using a zebrafish model. Biomacromolecules 2013 0.85
21 A dual-responsive mesoporous silica nanoparticle for tumor-triggered targeting drug delivery. Small 2013 0.85
22 The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel. Biomaterials 2009 0.85
23 In situ formation of thermosensitive PNIPAAm-based hydrogels by Michael-type addition reaction. ACS Appl Mater Interfaces 2010 0.85
24 A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles. Chem Commun (Camb) 2013 0.85
25 Activable Cell-Penetrating Peptide Conjugated Prodrug for Tumor Targeted Drug Delivery. ACS Appl Mater Interfaces 2015 0.84
26 Peptide hydrogel as an intraocular drug delivery system for inhibition of postoperative scarring formation. ACS Appl Mater Interfaces 2010 0.84
27 Galactosylated fluorescent labeled micelles as a liver targeting drug carrier. Biomaterials 2008 0.84
28 Study on novel hydrogels based on thermosensitive PNIPAAm with pH sensitive PDMAEMA grafts. Colloids Surf B Biointerfaces 2008 0.84
29 Core-shell nanosized assemblies mediated by the alpha-beta cyclodextrin dimer with a tumor-triggered targeting property. ACS Nano 2010 0.84
30 PEGylated PEI-based biodegradable polymers as non-viral gene vectors. Acta Biomater 2010 0.84
31 Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery. J Control Release 2009 0.83
32 A coumarin derivative as a fluorogenic glycoproteomic probe for biological imaging. Chem Commun (Camb) 2013 0.83
33 Cellular internalization and in vivo tracking of thermosensitive luminescent micelles based on luminescent lanthanide chelate. ACS Nano 2008 0.83
34 Dendrimer/DNA complexes encapsulated functional biodegradable polymer for substrate-mediated gene delivery. J Gene Med 2008 0.83
35 Prevention of filtering surgery failure by subconjunctival injection of a novel peptide hydrogel into rabbit eyes. Biomed Mater 2010 0.83
36 Synthesis of thermo- and pH-sensitive polyion complex micelles for fluorescent imaging. Chemistry 2012 0.82
37 A low-toxic and efficient gene vector: carboxymethyl dextran-graft-polyethylenimine. J Biomed Mater Res A 2008 0.82
38 Amphiphilic star-block copolymers and supramolecular transformation of nanogel-like micelles to nanovesicles. Chem Commun (Camb) 2011 0.82
39 Protamine sulfate/poly(L-aspartic acid) polyionic complexes self-assembled via electrostatic attractions for combined delivery of drug and gene. Biomaterials 2008 0.82
40 Fabrication of fast responsive, thermosensitive poly(N-isopropylacrylamide) hydrogels by using diethyl ether as precipitation agent. J Biomed Mater Res A 2008 0.82
41 Degradation and drug release property of star poly(epsilon-caprolactone)s with dendritic cores. J Biomed Mater Res B Appl Biomater 2007 0.82
42 Self-assembled thermo- and pH responsive micelles of poly(10-undecenoic acid-b-N-isopropylacrylamide) for drug delivery. J Control Release 2006 0.81
43 Theranostic GO-based nanohybrid for tumor induced imaging and potential combinational tumor therapy. Small 2013 0.81
44 In situ recognition of cell-surface glycans and targeted imaging of cancer cells. Sci Rep 2013 0.81
45 Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide for effective cell uptake and drug release. Nanotechnology 2009 0.81
46 Functionalized amphiphilic hyperbranched polymers for targeted drug delivery. Biomacromolecules 2008 0.81
47 Fabrication of supramolecular hydrogels for drug delivery and stem cell encapsulation. Langmuir 2008 0.81
48 Biotinylated transferrin/avidin/biotinylated disulfide containing PEI bioconjugates mediated p53 gene delivery system for tumor targeted transfection. Biomaterials 2010 0.81
49 Enhanced cardioprotective effects mediated by plasmid containing the short-hairpin RNA of angiotensin converting enzyme with a biodegradable hydrogel after myocardial infarction. J Biomed Mater Res A 2013 0.80
50 Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate. Bioconjug Chem 2011 0.80
51 Functionalized thermoresponsive micelles self-assembled from biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA for tumor cell target. Bioconjug Chem 2008 0.80
52 Strategy to introduce a pendent micellar structure into poly(N-isopropylacrylamide) hydrogels. Langmuir 2007 0.80
53 Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors. J Control Release 2008 0.80
54 Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for drug delivery. J Biomater Sci Polym Ed 2010 0.80
55 Formulation and characterization of chitosan-based hydrogel films having both temperature and pH sensitivity. J Mater Sci Mater Med 2007 0.79
56 Synergistic gene and drug tumor therapy using a chimeric peptide. Biomaterials 2013 0.79
57 Biotinylated thermoresponsive micelle self-assembled from double-hydrophilic block copolymer for drug delivery and tumor target. Biomaterials 2007 0.79
58 Hyperbranched polycarbonate-based multimolecular micelle with enhanced stability and loading efficiency. Macromol Rapid Commun 2010 0.79
59 Thermo-responsive shell cross-linked PMMA-b-P(NIPAAm-co-NAS) micelles for drug delivery. Int J Pharm 2011 0.79
60 Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery. Small 2006 0.79
61 Polyethyleneimine modified biocompatible poly(N-isopropylacrylamide)-based nanogels for drug delivery. J Nanosci Nanotechnol 2008 0.79
62 Thermo-triggered and biotinylated biotin-P(NIPAAm-co-HMAAm)-b-PMMA micelles for controlled drug release. J Biomed Mater Res A 2009 0.78
63 Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity. ACS Appl Mater Interfaces 2013 0.78
64 Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo. Biomaterials 2013 0.78
65 Self-Assembled Micelles Based on PEG-Polypeptide Hybrid Copolymers for Drug Delivery. Macromol Rapid Commun 2009 0.78
66 Self-assembly behavior of peptide amphiphiles (PAs) with different length of hydrophobic alkyl tails. Colloids Surf B Biointerfaces 2010 0.78
67 Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection. Macromol Rapid Commun 2012 0.78
68 Synthesis and applications of shell cross-linked thermoresponsive hybrid micelles based on poly(N-isopropylacrylamide-co-3-(trimethoxysilyl)propyl methacrylate)-b-poly(methyl methacrylate). Langmuir 2008 0.78
69 Coassembly of oppositely charged short peptides into well-defined supramolecular hydrogels. J Phys Chem B 2010 0.78
70 Enhanced nuclear import and transfection efficiency of TAT peptide-based gene delivery systems modified by additional nuclear localization signals. Bioconjug Chem 2011 0.78
71 N-Succinyl-chitosan grafted with low molecular weight polyethylenimine as a serum-resistant gene vector. Mol Biosyst 2009 0.78
72 Inhibition of enhanced green fluorescent protein expression by (dextran-hexamethylenediisocyanate)-g-polyethylenimine/siRNA complexes. J Microencapsul 2010 0.78
73 Controlled arrays of self-assembled peptide nanostructures in solution and at interface. Langmuir 2013 0.77
74 A peptide nanofibrous indicator for eye-detectable cancer cell identification. Small 2012 0.77
75 Fabrication of a novel temperature sensitive poly(N-isopropyl-3-butenamide) hydrogel. Colloids Surf B Biointerfaces 2007 0.77
76 Biotinylated disulfide containing PEI/avidin bioconjugate shows specific enhanced transfection efficiency in HepG2 cells. Org Biomol Chem 2009 0.77
77 Bioreducible polypeptide containing cell-penetrating sequence for efficient gene delivery. Pharm Res 2013 0.77
78 MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery. Chem Commun (Camb) 2014 0.77
79 Water soluble polymer protected lipofectamine 2000/DNA complexes for solid-phase transfection. Macromol Biosci 2009 0.77
80 A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery. Nanoscale 2015 0.77
81 Amphiphilic cationic lipopeptides with RGD sequences as gene vectors. Org Biomol Chem 2010 0.77
82 Evaluating the effects of charged oligopeptide motifs coupled with RGD on osteogenic differentiation of mesenchymal stem cells. ACS Appl Mater Interfaces 2015 0.77
83 Self-assembled thermosensitive micelles based on poly(L-lactide-star block-N-isopropylacrylamide) for drug delivery. J Biomed Mater Res A 2007 0.77
84 Design of a cellular-uptake-shielding "plug and play" template for photo controllable drug release. Adv Mater 2011 0.77
85 Fabrication of a novel pH-sensitive glutaraldehyde cross-linked pectin nanogel for drug delivery. J Biomater Sci Polym Ed 2007 0.77
86 Fabrication of lactobionic-loaded chitosan microcapsules as potential drug carriers targeting the liver. Acta Biomater 2010 0.77
87 Long-term thiol monitoring in living cells using bioorthogonal chemistry. Chem Commun (Camb) 2015 0.77
88 Avidin-biotin interaction mediated peptide assemblies as efficient gene delivery vectors for cancer therapy. Mol Pharm 2012 0.77
89 Porphyrin and galactosyl conjugated micelles for targeting photodynamic therapy. Pharm Res 2009 0.77
90 Polymeric assembly of hyperbranched building blocks to establish tunable nanoplatforms for lysosome acidity-responsive gene/drug co-delivery. Biomater Sci 2014 0.77
91 Cancer-targeted functional gold nanoparticles for apoptosis induction and real-time imaging based on FRET. Nanoscale 2014 0.76
92 Construction of surfactant-like tetra-tail amphiphilic peptide with RGD ligand for encapsulation of porphyrin for photodynamic therapy. Biomaterials 2010 0.76
93 Photo-switched self-assembly of a gemini α-helical peptide into supramolecular architectures. Nanoscale 2013 0.76
94 Modular Synthesis of Thermosensitive P(NIPAAm-co-HEMA)/β-CD Based Hydrogels via Click Chemistry. Macromol Rapid Commun 2008 0.76
95 Controllable exploding microcapsules as drug carriers. Chem Commun (Camb) 2011 0.76
96 Evaluation of RGD peptide hydrogel in the posterior segment of the rabbit eye. J Biomater Sci Polym Ed 2012 0.76
97 Dendrimer/DNA complexes encapsulated in a water soluble polymer and supported on fast degrading star poly(DL-lactide) for localized gene delivery. J Control Release 2007 0.76
98 Galactosyl conjugated N-succinyl-chitosan-graft-polyethylenimine for targeting gene transfer. Mol Biosyst 2010 0.76
99 Design of a cellular-uptake-shielding magnetic catcher for cancer cell separation. Macromol Biosci 2012 0.76
100 Evaluation of the biocompatibility of novel peptide hydrogel in rabbit eye. J Biomed Mater Res B Appl Biomater 2010 0.76
101 Self-assembled micelles of novel graft amphiphilic copolymers for drug controlled release. Colloids Surf B Biointerfaces 2010 0.76
102 Design of a photoswitchable hollow microcapsular drug delivery system by using a supramolecular drug-loading approach. J Phys Chem B 2011 0.76
103 Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug. Chem Commun (Camb) 2015 0.76
104 A multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy. Nanoscale 2015 0.76
105 A smart micellar system with an amine-containing polycarbonate shell. Acta Biomater 2011 0.76
106 Preparation of novel ferrocene-based shell cross-linked thermoresponsive hybrid micelles with antitumor efficacy. J Phys Chem B 2010 0.76
107 One-pot construction of functional mesoporous silica nanoparticles for the tumor-acidity-activated synergistic chemotherapy of glioblastoma. ACS Appl Mater Interfaces 2013 0.76
108 High length-diameter ratio nanotubes self-assembled from a facial cyclopeptide. Soft Matter 2014 0.75
109 Self-assembled BolA-like amphiphilic peptides as viral-mimetic gene vectors for cancer cell targeted gene delivery. Macromol Biosci 2012 0.75
110 Peptide-functionalized thermo-sensitive hydrogels for sustained drug delivery. Macromol Biosci 2009 0.75
111 Surface self-assembly of N-fluorenyl-9-methoxycarbonyl diphenylalanine on silica wafer. Colloids Surf B Biointerfaces 2011 0.75
112 PEG-stabilized micellar system with positively charged polyester core for fast pH-responsive drug release. Pharm Res 2012 0.75
113 Morphology transformation via pH-triggered self-assembly of peptides. Langmuir 2011 0.75
114 A plug and play polymeric template driven by supramolecular interactions. J Biomed Mater Res A 2011 0.75
115 Fabrication and characterization of a novel composite PNIPAAm hydrogel for controlled drug release. J Biomed Mater Res A 2007 0.75
116 Controlling the growth behaviour of multilayered films via layer-by-layer assembly with multiple interactions. Phys Chem Chem Phys 2009 0.75
117 Poly(β-amino amine) cross-linked PEIs as highly efficient gene vectors. Acta Biomater 2011 0.75
118 Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) graft copolymers. Colloids Surf B Biointerfaces 2007 0.75
119 Mimicking the biological ligand-receptor principle for universal target gene delivery mediated by avidin-biotin interaction. Adv Healthc Mater 2012 0.75
120 Fabrication and in vitro drug release of drug-loaded star oligo/poly(DL-lactide) microspheres made by novel ultrasonic-dispersion method. J Biomed Mater Res A 2007 0.75
121 A FRET-based dual-targeting theranostic chimeric peptide for tumor therapy and real-time apoptosis imaging. Adv Healthc Mater 2014 0.75
122 Co-delivery of proapoptotic peptide and p53 DNA by reduction-sensitive polypeptides for cancer therapy. Biomater Sci 2015 0.75
123 Bilayer matrix composed of polycation/DNA complex and sodium alginate gel as a tumor cell catcher. Macromol Biosci 2011 0.75
124 Acidity-promoted cellular uptake and drug release mediated by amine-functionalized block polycarbonates prepared via one-shot ring-opening copolymerization. Macromol Biosci 2013 0.75
125 Cucurbit[8]uril-mediated supramolecular photoswitching for self-preservation of mesoporous silica nanoparticle delivery system. Chem Commun (Camb) 2015 0.75
126 Enzyme-Driven Membrane-Targeted Chimeric Peptide for Enhanced Tumor Photodynamic-Immunotherapy. ACS Nano 2019 0.75
127 An innovative pre-targeting strategy for tumor cell specific imaging and therapy. Nanoscale 2015 0.75
128 A novel function of BMHP1 and cBMHP1 peptides to induce the osteogenic differentiation of mesenchymal stem cells. Biomater Sci 2014 0.75
129 Fabrication of microparticle protein delivery systems based on calcium alginate. J Microencapsul 2010 0.75
130 One-step preparation and pH-tunable self-aggregation of amphoteric aliphatic polycarbonates bearing plenty of amine and carboxyl groups. Macromol Biosci 2012 0.75
131 Epigenetics-Based Tumor Cells Pyroptosis for Enhancing Immunological Effect of Chemotherapeutic Nano-Carriers. Nano Lett 2019 0.75
132 Nanofibers Self-assembled from Structural Complementary Borono-decapeptides. Macromol Rapid Commun 2010 0.75
133 Study on drug release behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) nano- and microparticles. Biomacromolecules 2006 0.75
134 Convenient preparation of biodegradable PEI-containing polymers as non-viral vectors for gene transfection. Macromol Biosci 2009 0.75
135 Effect of peptides and their introduction methods on target gene transfer of gene vector based on disulfide-containing polyethyleneimine. Int J Pharm 2012 0.75
136 A potential targeting gene vector based on biotinylated polyethyleneimine/avidin bioconjugates. Pharm Res 2009 0.75
137 Poly(methyl methacrylate)-graft-oligoamines as low cytotoxic and efficient nonviral gene vectors. Mol Biosyst 2009 0.75
138 A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy. Chem Commun (Camb) 2014 0.75
139 Calcium phosphate/DNA co-precipitates encapsulated fast-degrading polymer films for substrate-mediated gene delivery. J Biomed Mater Res B Appl Biomater 2009 0.75
140 Interface self-assembly to construct vertical peptide nanorods on quartz template. Chem Commun (Camb) 2011 0.75
141 A nanosized, thermo-sensitive drug carrier: self-assembled Fe(3)O(4)-OA-g-P(OA-co-NIPAAm) magnetomicelles. J Biomater Sci Polym Ed 2008 0.75
142 The tuned-morphology studies of the complexes between poly(N-isopropylacrylamide)-b-poly(vinylpyridine) and poly(N-isopropylacrylamide-co-hydroxylethyl methacrylate)-b-poly(vinylphenol). J Colloid Interface Sci 2008 0.75
143 Novel gene transfer vectors based on artificial recombinant multi-functional oligopeptides. Int J Pharm 2012 0.75
144 Supramolecular architectures self-assembled from asymmetrical hetero cyclopeptides. Macromol Rapid Commun 2011 0.75
145 Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery. ACS Appl Mater Interfaces 2016 0.75
146 Peptide-based vector of VEGF plasmid for efficient gene delivery in vitro and vessel formation in vivo. Bioconjug Chem 2013 0.75
147 Tyroserleutide-based gene vector for suppressing VEGF expression in cancer therapy. Biomaterials 2012 0.75
148 Influential factors associated with biotinylated disulfide containing PEI/avidin bioconjugate mediated gene delivery in HepG2 cells. Mol Biosyst 2010 0.75
149 Synthesis, characterization, and degradation behavior of amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone). Biomacromolecules 2005 0.75
150 Effect of ions on the aggregation behavior of natural polymer alginate. J Phys Chem B 2009 0.75
151 Novel cholic acid functionalized star oligo/poly(DL-lactide)s for biomedical applications. J Biomed Mater Res B Appl Biomater 2007 0.75
152 Stepwise-acid-active multifunctional mesoporous silica nanoparticles for tumor-specific nucleus-targeted drug delivery. ACS Appl Mater Interfaces 2014 0.75
153 Stimuli-Responsive "Cluster Bomb" for Programmed Tumor Therapy. ACS Nano 2017 0.75
154 Facile construction of nanofibers as a functional template for surface boron coordination reaction. Small 2011 0.75
155 Novel thermoresponsive nonviral gene vector: P(NIPAAm-co-NDAPM)-b-PEI with adjustable gene transfection efficiency. Bioconjug Chem 2008 0.75
156 Novel vesicles self-assembled from amphiphilic star-armed PEG/polypeptide hybrid copolymers for drug delivery. Macromol Biosci 2010 0.75
157 Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs. Chem Commun (Camb) 2015 0.75
158 PEGylated peptide based reductive polycations as efficient nonviral gene vectors. Adv Healthc Mater 2012 0.75
159 Thermosensitive P(NIPAAm-co-PAAc-co-HEMA) nanogels conjugated with transferrin for tumor cell targeting delivery. Nanotechnology 2008 0.75
160 Cholic acid functionalized star poly(DL-lactide) for promoting cell adhesion and proliferation. J Tissue Eng Regen Med 2007 0.75
161 Fabrication of novel reduction-sensitive gene vectors based on three-armed peptides. Macromol Biosci 2013 0.75
162 Synthesis and properties of pH and temperature sensitive P(NIPAAm-co-DMAEMA) hydrogels. Colloids Surf B Biointerfaces 2008 0.75
163 Degradable nanogels as a nanoreactor for growing silica colloids. Langmuir 2009 0.75
164 Gene expression mediated by dendrimer/DNA complexes encapsulated in biodegradable polymer microspheres. J Microencapsul 2010 0.75
165 Rational Design of Multifunctional Gold Nanoparticles via Host-Guest Interaction for Cancer-Targeted Therapy. ACS Appl Mater Interfaces 2015 0.75
166 A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3. Chem Commun (Camb) 2015 0.75
167 Synthesis of novel cholic acid functionalized branched oligo/poly(epsilon-caprolactone)s for biomedical applications. J Biomed Mater Res A 2007 0.75