Chlamydia pneumoniae-induced memory CD4+ T-cell activation in human peripheral blood correlates with distinct antibody response patterns.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 2863398)

Published in Clin Vaccine Immunol on March 10, 2010

Authors

Sebastian Bunk1, Hanne Schaffert, Bianca Schmid, Christoph Goletz, Sabine Zeller, Marina Borisova, Florian Kern, Jan Rupp, Corinna Hermann

Author Affiliations

1: Department of Biochemical Pharmacology, University of Konstanz, Konstanz, Germany. sebastian.bunk@gmx.net

Articles cited by this

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47

Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis. Proc Natl Acad Sci U S A (2003) 4.00

Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev (2004) 3.98

Understanding the generation and function of memory T cell subsets. Curr Opin Immunol (2005) 3.22

Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol (2005) 3.04

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med (2005) 2.92

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med (2005) 2.83

Chlamydial persistence: beyond the biphasic paradigm. Infect Immun (2004) 2.78

Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol Rev (2006) 2.75

Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat Rev Immunol (2006) 2.52

Chlamydia pneumoniae--an infectious risk factor for atherosclerosis? Nat Rev Microbiol (2004) 2.34

Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis (2002) 2.33

Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load. Eur J Immunol (2004) 2.05

Cutting edge: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function. J Immunol (2002) 1.98

Chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies. Clin Microbiol Rev (2002) 1.45

Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol (1999) 1.39

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc Natl Acad Sci U S A (2003) 1.37

In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7. J Immunol (2002) 1.32

Chlamydia pneumoniae and atherosclerosis. Cell Microbiol (2004) 1.23

Antigen-specific central memory CD4+ T lymphocytes produce multiple cytokines and proliferate in vivo in humans. J Immunol (2006) 1.17

Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response. J Clin Invest (2005) 1.17

The intracellular life of chlamydiae. Semin Pediatr Infect Dis (2002) 1.13

Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen. J Immunol (2002) 1.11

Proteomic analysis of differentially expressed Chlamydia pneumoniae genes during persistent infection of HEp-2 cells. Infect Immun (2002) 1.10

Local immune responses to Chlamydia pneumoniae in the lungs of BALB/c mice during primary infection and reinfection. Infect Immun (1998) 1.09

Involvement of Chlamydia pneumoniae in atherosclerosis: more evidence for lack of evidence. J Clin Microbiol (2005) 1.08

Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J Immunol (2005) 1.05

Macrophages, CD4+ or CD8+ cells are each sufficient for protection against Chlamydia pneumoniae infection through their ability to secrete IFN-gamma. J Immunol (2004) 1.04

Depletion of CD8+ cells abolishes memory in acquired immunity against Chlamydia pneumoniae in BALB/c mice. Immunology (1999) 1.03

Cross-presentation: dendritic cells and macrophages bite off more than they can chew! Immunology (2004) 1.01

Immunoproteomic identification and serological responses to novel Chlamydia pneumoniae antigens that are associated with persistent C. pneumoniae infections. J Immunol (2008) 1.01

Protein expression profiles of Chlamydia pneumoniae in models of persistence versus those of heat shock stress response. Infect Immun (2006) 0.96

Regulation of transcriptional activity of the murine CD40 ligand promoter in response to signals through TCR and the costimulatory molecules CD28 and CD2. J Immunol (2001) 0.92

Characterization of a subset of antigen-specific human central memory CD4+ T lymphocytes producing effector cytokines. Eur J Immunol (2008) 0.91

Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. Immunobiology (2004) 0.89

Identification of an in vivo CD4+ T cell-mediated response to polymorphic membrane proteins of Chlamydia pneumoniae during experimental infection. FEMS Immunol Med Microbiol (2004) 0.85

Chlamydia trachomatis infection alters the development of memory CD8+ T cells. J Immunol (2006) 0.84

CD8+ T cells specific for a potential HLA-A*0201 epitope from Chlamydophila pneumoniae are present in the PBMCs from infected patients. Int Immunol (2005) 0.80

Chlamydia pneumoniae, stroke, and serological associations: anything learned from the atherosclerosis-cardiovascular literature or do we have to start over again? Stroke (2006) 0.78

Articles by these authors

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med (2005) 7.18

Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol (2004) 3.13

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids. Proc Natl Acad Sci U S A (2005) 2.82

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut (2011) 2.80

Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells. J Exp Med (2005) 2.28

Diagnosis of childhood tuberculosis and host RNA expression in Africa. N Engl J Med (2014) 2.12

Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J Allergy Clin Immunol (2011) 2.06

Raf-1 addiction in Ras-induced skin carcinogenesis. Cancer Cell (2009) 1.99

Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Med (2013) 1.91

Random screening of proteins for HLA-A*0201-binding nine-amino acid peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A*0201. J Immunol (2004) 1.68

High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med (Berl) (2003) 1.66

Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J Clin Invest (2006) 1.58

Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination. J Infect Dis (2010) 1.58

Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes. Infect Immun (2006) 1.57

The T-helper cell type 1 immune response to gram-negative bacterial infections is impaired in COPD. Am J Respir Crit Care Med (2010) 1.56

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol (2005) 1.49

Association between azithromycin therapy and duration of bacterial shedding among patients with Shiga toxin-producing enteroaggregative Escherichia coli O104:H4. JAMA (2012) 1.47

Structural decomposition and heterogeneity of commercial lipoteichoic Acid preparations. Infect Immun (2002) 1.46

Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model. Blood (2011) 1.44

Loss of receptor on tuberculin-reactive T-cells marks active pulmonary tuberculosis. PLoS One (2007) 1.39

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology (2011) 1.34

Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J Infect Dis (2003) 1.28

Mapping T cell epitopes by flow cytometry. Methods (2003) 1.27

Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses. J Virol (2011) 1.24

Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis. J Immunol (2004) 1.24

Analysis of antigen-specific T-cell responses with synthetic peptides--what kind of peptide for which purpose? Hum Immunol (2004) 1.24

Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immun Ageing (2010) 1.22

D-alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract. Environ Microbiol (2007) 1.20

Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing (2011) 1.19

CMV and Immunosenescence: from basics to clinics. Immun Ageing (2012) 1.17

Genotypic differences in the Chlamydia pneumoniae tyrP locus related to vascular tropism and pathogenicity. J Infect Dis (2003) 1.16

Cytokine induction by Gram-positive bacteria. Immunobiology (2008) 1.15

High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function. Transpl Immunol (2008) 1.10

CMV-specific central memory T cells reside in bone marrow. Eur J Immunol (2007) 1.08

How flow cytometry is changing the study of TB immunology and clinical diagnosis. Cytometry A (2008) 1.08

Mycoplasma pneumoniae and Chlamydia spp. infection in community-acquired pneumonia, Germany, 2011-2012. Emerg Infect Dis (2015) 1.08

Hypoxia abrogates antichlamydial properties of IFN-γ in human fallopian tube cells in vitro and ex vivo. Proc Natl Acad Sci U S A (2010) 1.07

Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material. Pathol Res Pract (2005) 1.04

Confirmation of Mycobacterium tuberculosis infection by flow cytometry after ex vivo incubation of peripheral blood T cells with an ESAT-6-derived peptide pool. Cytometry B Clin Cytom (2004) 1.02

MDP and other muropeptides--direct and synergistic effects on the immune system. J Endotoxin Res (2006) 1.01

Gender difference in cytokine secretion on immune stimulation with LPS and LTA. J Interferon Cytokine Res (2006) 1.01

Immunoproteomic identification and serological responses to novel Chlamydia pneumoniae antigens that are associated with persistent C. pneumoniae infections. J Immunol (2008) 1.01

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol (2009) 1.01

The TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae. Respir Res (2010) 1.00

Targeting of a chlamydial protease impedes intracellular bacterial growth. PLoS Pathog (2011) 0.98

Persistence of HCV in quiescent hepatic cells under conditions of an interferon-induced antiviral response. Gastroenterology (2012) 0.98

Modulation of the inflammatory response to Streptococcus pneumoniae in a model of acute lung tissue infection. Am J Respir Cell Mol Biol (2008) 0.98

Disparate innate immune responses to persistent and acute Chlamydia pneumoniae infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 0.97

Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β - A Possible Pathway of Exacerbations in COPD. PLoS One (2013) 0.97

Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun (2004) 0.97

Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction. J Biol Chem (2003) 0.97

The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease. Am J Pathol (2010) 0.96

Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation. Circulation (2003) 0.96

Internalization and coreceptor expression are critical for TLR2-mediated recognition of lipoteichoic acid in human peripheral blood. J Immunol (2010) 0.95

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA. J Immunol (2013) 0.95

Exploitation of integrin function by pathogenic microbes. Curr Opin Cell Biol (2012) 0.94

Genetic diversity of the obligate intracellular bacterium Chlamydophila pneumoniae by genome-wide analysis of single nucleotide polymorphisms: evidence for highly clonal population structure. BMC Genomics (2007) 0.94

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice. Blood (2012) 0.94

Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol (2007) 0.94

The interleukin-6 -174 promoter polymorphism is associated with extrapulmonary bacterial dissemination in Streptococcus pneumoniae infection. Cytokine (2005) 0.92

A novel cytomegalovirus-induced regulatory-type T-cell subset increases in size during older life and links virus-specific immunity to vascular pathology. J Infect Dis (2013) 0.92

Impact of a low-oxygen environment on the efficacy of antimicrobials against intracellular Chlamydia trachomatis. Antimicrob Agents Chemother (2011) 0.91

Be aware of the possibility of false-positive results in single-locus PCR assays for methicillin-resistant Staphylococcus aureus. J Clin Microbiol (2006) 0.91

Critical evaluation of urine-based PCR assay for diagnosis of Lyme borreliosis. Clin Diagn Lab Immunol (2005) 0.91

First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae. Antimicrob Agents Chemother (2004) 0.91

Chlamydophila pneumoniae. Mechanisms of target cell infection and activation. Thromb Haemost (2005) 0.91

Endotoxin evaluation of eleven lipopolysaccharides by whole blood assay does not always correlate with Limulus amebocyte lysate assay. J Endotoxin Res (2006) 0.90

Enumeration of antigen-specific CD8+ T lymphocytes by single-platform, HLA tetramer-based flow cytometry: a European multicenter evaluation. Cytometry B Clin Cytom (2004) 0.90

A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nat Chem Biol (2013) 0.90

Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. Immunobiology (2004) 0.89

Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue. Invest Ophthalmol Vis Sci (2008) 0.89

Detection of antigen-specific T cells by cytokine flow cytometry: the use of whole blood may underestimate frequencies. Eur J Immunol (2003) 0.89

Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions. PLoS One (2013) 0.88

Mechanisms of cilia-driven transport in the airways in the absence of mucus. Am J Respir Cell Mol Biol (2014) 0.88

Molecular basis for detection of invading pathogens in the brain. J Neurosci Res (2008) 0.88

Nogo receptor is involved in the adhesion of dendritic cells to myelin. J Neuroinflammation (2011) 0.87

Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis. Basic Res Cardiol (2002) 0.87

The role of flow cytometry in the interferon-gamma-based diagnosis of active tuberculosis and its coinfection with HIV-1--A technically oriented review. Cytometry B Clin Cytom (2008) 0.87

Different Staphylococcus aureus whole bacteria mutated in putative pro-inflammatory membrane components have similar cytokine inducing activity. Immunobiology (2010) 0.87

Measurement of antigen specific immune responses: 2006 update. Cytometry B Clin Cytom (2007) 0.87

The phenotypic distribution and functional profile of tuberculin-specific CD4 T-cells characterizes different stages of TB infection. Cytometry B Clin Cytom (2012) 0.87

T cell response to the cytomegalovirus major capsid protein (UL86) is dominated by helper cells with a large polyfunctional component and diverse epitope recognition. J Infect Dis (2008) 0.87

Cross-reactivity among fungal allergens: a clinically relevant phenomenon? Mycoses (2008) 0.86

Fluorescence lifetime imaging unravels C. trachomatis metabolism and its crosstalk with the host cell. PLoS Pathog (2011) 0.86

Molecular cartography in acute Chlamydia pneumoniae infections--a non-targeted metabolomics approach. Anal Bioanal Chem (2013) 0.86

NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy. PLoS One (2008) 0.86

Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation? Cell Immunol (2010) 0.86

Selection and depletion of plasma cells based on the specificity of the secreted antibody. Eur J Immunol (2014) 0.85

HLA type-independent generation of antigen-specific T cells for adoptive immunotherapy. Eur J Immunol (2005) 0.85

Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember? Med Microbiol Immunol (2010) 0.84

When oxygen runs short: the microenvironment drives host-pathogen interactions. Microbes Infect (2011) 0.84

Dexamethasone increases hippocampal neuronal apoptosis in a rabbit model of Escherichia coli meningitis. Pediatr Res (2006) 0.84

Insulin-like growth factor-I regulates the neonatal immune response in infection and maturation by suppression of IFN-γ. Cytokine (2012) 0.83

Comment on "Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus". J Immunol (2007) 0.83

Asymptomatic carotid atherosclerosis is associated with circulating chlamydia pneumoniae DNA in younger normotensive subjects in a general population survey. Arterioscler Thromb Vasc Biol (2004) 0.83

hCG in trophoblast tumour cells of the cell line Jeg3 and hCG isolated from amniotic fluid and serum of pregnant women carry oligosaccharides of the sialyl Lewis X and sialyl Lewis a type. Anticancer Res (2003) 0.83

HIV interferes with SOCS-1 and -3 expression levels driving immune activation. Eur J Immunol (2011) 0.83

Dissection of the CMV specific T-cell response is required for optimized cardiac transplant monitoring. J Med Virol (2008) 0.82

Growth cycle-dependent pharmacodynamics of antichlamydial drugs. Antimicrob Agents Chemother (2005) 0.82