PubRank

Leslie M Thompson

Author PubWeight™ 35.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc Natl Acad Sci U S A 2003 4.44
2 Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 2008 4.43
3 Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004 3.73
4 Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nat Chem Biol 2011 2.24
5 SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc Natl Acad Sci U S A 2010 2.09
6 Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet 2006 1.77
7 Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo. J Biol Chem 2010 1.62
8 Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies. Proc Natl Acad Sci U S A 2005 1.52
9 Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol Med 2010 1.27
10 A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet 2002 1.25
11 Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis 2012 1.23
12 Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle. J Biol Chem 2010 1.01
13 Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation. Mech Ageing Dev 2005 1.00
14 Targeting H3K4 trimethylation in Huntington disease. Proc Natl Acad Sci U S A 2013 0.98
15 Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation. Neurobiol Dis 2003 0.97
16 Fly models of Huntington's disease. Hum Mol Genet 2003 0.97
17 Arfaptin 2 regulates the aggregation of mutant huntingtin protein. Nat Cell Biol 2002 0.93
18 Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A 2013 0.93
19 Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. J Neurosci 2012 0.92
20 SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Rep 2013 0.88
21 Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain. J Neurochem 2002 0.84
22 Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin. J Biol Chem 2012 0.80
23 Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background. J Huntingtons Dis 2012 0.80