Published in Best Pract Res Clin Gastroenterol on April 01, 2010
Molecular mechanisms elucidating why old stomach is more vulnerable to indomethacin-induced damage than young stomach. Dig Dis Sci (2012) 2.05
The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Br J Pharmacol (2011) 1.18
The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. Br J Pharmacol (2012) 1.08
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacol Res (2012) 1.06
Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer. J Gastroenterol (2013) 1.03
Anti-inflammatory iridoids of botanical origin. Curr Med Chem (2012) 1.00
Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther (2013) 1.00
Bovine immunoglobulin protein isolates for the nutritional management of enteropathy. World J Gastroenterol (2014) 0.92
Future directions for the management of pain in osteoarthritis. Int J Clin Rheumtol (2014) 0.89
Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. Scand J Gastroenterol (2013) 0.88
Protective effects of garlic extract, PMK-S005, against nonsteroidal anti-inflammatory drugs-induced acute gastric damage in rats. Dig Dis Sci (2014) 0.86
Mesotherapy versus Systemic Therapy in the Treatment of Acute Low Back Pain: A Randomized Trial. Evid Based Complement Alternat Med (2010) 0.86
Validation of ICD-9-CM codes to identify gastrointestinal perforation events in administrative claims data among hospitalized rheumatoid arthritis patients. Pharmacoepidemiol Drug Saf (2011) 0.85
Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.84
Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells. Cytotechnology (2011) 0.82
Dietary requirement for serum-derived bovine immunoglobulins in the clinical management of patients with enteropathy. Dig Dis Sci (2014) 0.82
[Inpatient pain consultation service at a university hospital: a retrospective analysis of patient characteristics and the rate of the implementation of recommendations]. Schmerz (2012) 0.82
NSAID enteropathy: could probiotics prevent it? J Gastroenterol (2012) 0.81
NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip. PLoS One (2015) 0.81
The Anti-Inflammatory Effect of Algae-Derived Lipid Extracts on Lipopolysaccharide (LPS)-Stimulated Human THP-1 Macrophages. Mar Drugs (2015) 0.81
Safety issues of current analgesics: an update. Clujul Med (2015) 0.80
Efficacy of celecoxib for acute pain management following total hip arthroplasty in elderly patients: A prospective, randomized, placebo-control trial. Exp Ther Med (2015) 0.79
Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies. BMC Complement Altern Med (2016) 0.78
Aspirin resistance and other aspirin-related concerns. Neurol Sci (2015) 0.78
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. PLoS One (2015) 0.78
Exacerbation of celecoxib-induced renal injury by concomitant administration of misoprostol in rats. PLoS One (2014) 0.78
Anti-inflammatory activity of aqueous extract and bioactive compounds identified from the fruits of Hancornia speciosa Gomes (Apocynaceae). BMC Complement Altern Med (2016) 0.76
Interobserver variation in the endoscopic diagnosis of gastroduodenal ulcer scars: implications for clinical management of NSAIDs users. BMC Res Notes (2011) 0.76
In vitro xanthine oxidase and albumin denaturation inhibition assay of Barringtonia racemosa L. and total phenolic content analysis for potential anti-inflammatory use in gouty arthritis. J Intercult Ethnopharmacol (2016) 0.75
PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach. Gut Liver (2016) 0.75
Gastrointestinal comorbidities associated with atrial fibrillation. Springerplus (2014) 0.75
Stercoral perforation in a child: a rare complication of NSAID use. BMJ Case Rep (2014) 0.75
4,5,4'-Trihydroxychalcone, 8,8'-(ethene-1,2-diyl)-dinaphtalene-1,4,5-triol and rutin from Gynura segetum inhibit phagocytosis, lymphocyte proliferation, cytokine release and nitric oxide production from phagocytic cells. BMC Complement Altern Med (2017) 0.75
Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial. BMC Gastroenterol (2016) 0.75
Impairment of salivary mucin production resulting in declined salivary viscosity during naproxen administration as a potential link to upper alimentary tract mucosal injury. Clin Transl Gastroenterol (2013) 0.75
Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment. J Multidiscip Healthc (2014) 0.75
Acid-reducing vagotomy is associated with reduced risk of subsequent ischemic heart disease in complicated peptic ulcer: An Asian population study. Medicine (Baltimore) (2016) 0.75
Cat's whiskers (Orthosiphon stamineus) tea modulates arthritis pathogenesis via the angiogenesis and inflammatory cascade. BMC Complement Altern Med (2016) 0.75
Amtolmetin: A Reappraisal of NSAID with Gastroprotection. Arthritis (2016) 0.75
Predictors of pain medication use for arthroplasty pain after revision total knee arthroplasty. Rheumatology (Oxford) (2014) 0.75
Perforated diverticulitis sigmoidei after laparoscopic cholecystectomy. J Surg Case Rep (2015) 0.75
Pes Anserine Bursitis in Symptomatic Osteoarthritis Patients: A Mesotherapy Treatment Study. J Altern Complement Med (2015) 0.75
Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats. Pharm Res (2013) 0.75
Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats. Inflammopharmacology (2017) 0.75
Polycaprolactone Based Nanoparticles Loaded with Indomethacin for Anti-Inflammatory Therapy: From Preparation to Ex Vivo Study. Pharm Res (2017) 0.75
Protective role of misoprostol against cisplatin-induced ototoxicity. Eur Arch Otorhinolaryngol (2016) 0.75
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med (2005) 15.46
Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med (2010) 7.39
Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet (2010) 5.05
A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. Gastroenterology (2006) 3.35
Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet (2008) 2.83
Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials. Am J Med (2012) 2.23
[Current management of nonvariceal upper gastrointestinal bleeding in Spain]. Gastroenterol Hepatol (2012) 2.04
Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin. Am J Gastroenterol (2008) 1.99
Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol (2007) 1.92
A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract. J Rheumatol (2009) 1.81
Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol (2007) 1.67
Low-dose aspirin affects the small bowel mucosa: results of a pilot study with a multidimensional assessment. Clin Gastroenterol Hepatol (2008) 1.62
Risk of cancer in cases of suspected lynch syndrome without germline mutation. Gastroenterology (2013) 1.55
Risk of advanced proximal neoplasms according to distal colorectal findings: comparison of sigmoidoscopy-based strategies. J Natl Cancer Inst (2013) 1.47
Cardiovascular and upper gastrointestinal bleeding consequences of low-dose acetylsalicylic acid discontinuation. Thromb Haemost (2013) 1.43
Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions. Ann Rheum Dis (2012) 1.33
Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. Gastroenterology (2012) 1.15
Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies. Gastrointest Endosc (2012) 1.15
Consensus development conference on the use of nonsteroidal anti-inflammatory agents, including cyclooxygenase-2 enzyme inhibitors and aspirin. Clin Gastroenterol Hepatol (2006) 1.13
Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype. Gastroenterology (2010) 1.11
The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. Helicobacter (2004) 1.05
The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel. Ann Rheum Dis (2010) 1.02
MLH1 founder mutations with moderate penetrance in Spanish Lynch syndrome families. Cancer Res (2010) 1.01
Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther (2013) 1.00
Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus. World J Gastroenterol (2005) 0.99
Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review. Heart (2012) 0.98
Association between achalasia and nitric oxide synthase gene polymorphisms. Am J Gastroenterol (2006) 0.95
Gastrointestinal effects of aspirin. Nat Rev Gastroenterol Hepatol (2011) 0.94
Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors. Drug Healthc Patient Saf (2009) 0.94
Editorial: Upper GI bleeding-associated mortality: challenges to improving a resistant outcome. Am J Gastroenterol (2010) 0.93
Factors associated with gastrointestinal perforation in a cohort of patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) (2012) 0.92
Cost-effectiveness of colorectal cancer screening in high-risk Spanish patients: use of a validated model to inform public policy. Cancer Epidemiol Biomarkers Prev (2010) 0.92
Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus. Prostaglandins Other Lipid Mediat (2006) 0.91
Trends in Barrett's esophagus diagnosis in Southern Europe: implications for surveillance. Dis Esophagus (2009) 0.90
[Clinical practice guideline. Prevention of colorectal cancer. 2009 update. Asociación Española de Gastroenterología]. Gastroenterol Hepatol (2009) 0.90
Prevention and Treatment of NSAID Gastropathy. Curr Treat Options Gastroenterol (2014) 0.90
Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. Helicobacter (2005) 0.89
Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus. World J Gastroenterol (2005) 0.88
Myths and facts in the use of anti-inflammatory drugs. Ann Med (2009) 0.88
Evidence for endoscopic ulcers as meaningful surrogate endpoint for clinically significant upper gastrointestinal harm. Clin Gastroenterol Hepatol (2009) 0.88
Barrett's esophagus: natural history. Ann N Y Acad Sci (2011) 0.88
Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype. Mutagenesis (2012) 0.87
Relevance of IL-1 and TNF gene polymorphisms on interleukin-1beta and tumor necrosis factor-alpha gastric mucosal production. Hum Immunol (2009) 0.87
Management of colonic diverticular disease with poorly absorbed antibiotics and other therapies. Therap Adv Gastroenterol (2011) 0.86
Epidemiology and demographics of upper gastrointestinal bleeding: prevalence, incidence, and mortality. Gastrointest Endosc Clin N Am (2011) 0.86
Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection. ACS Chem Biol (2009) 0.86
Managing the adverse effects of nonsteroidal anti-inflammatory drugs. Expert Rev Clin Pharmacol (2011) 0.86
Gastrointestinal adverse effects of short-term aspirin use: a meta-analysis of published randomized controlled trials. Drugs R D (2013) 0.84
CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate. BMC Gastroenterol (2006) 0.84
Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice. Int J Oncol (2011) 0.84
Is NSAIDs-related gastrointestinal damage preventable? J Dig Dis (2013) 0.83
Efficacy and safety of piroxicam revisited. A global meta-analysis of randomised clinical trials. Pharmacol Res (2009) 0.83
Role of gastrin-peptides in Barrett's and colorectal carcinogenesis. World J Gastroenterol (2012) 0.81
Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer. Cancer Lett (2005) 0.81
Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma. PLoS One (2012) 0.79
Helicobacter pylori and nonmalignant diseases. Helicobacter (2013) 0.79
Optimizing the use of aspirin for cardiovascular prevention. Drugs (2013) 0.78
Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease. Hum Immunol (2005) 0.78
Cardiac function and aminoterminal pro-brain natriuretic peptide levels in liver-transplanted cirrhotic patients. Clin Transplant (2011) 0.78
Participation and detection rates by age and sex for colonoscopy versus fecal immunochemical testing in colorectal cancer screening. Cancer Causes Control (2014) 0.78
A case-control study of the association between polymorphisms of the endothelial nitric oxide synthase and glycoprotein IIIa genes and upper gastrointestinal bleeding in users of low-dose aspirin. Clin Ther (2008) 0.78
Gastrointestinal lesions and complications of low-dose aspirin in the gastrointestinal tract. Best Pract Res Clin Gastroenterol (2012) 0.77
Esomeprazole for prevention and resolution of upper gastrointestinal symptoms in patients treated with low-dose acetylsalicylic acid for cardiovascular protection: the OBERON trial. J Cardiovasc Pharmacol (2013) 0.77
[The Alliance for the Prevention of Colorectal Cancer in Spain. A civil commitment to society]. Gastroenterol Hepatol (2012) 0.77
European physicians don't like cytoprotective agents? J Clin Biochem Nutr (2011) 0.77
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. World J Gastroenterol (2012) 0.77
Management of low-dose aspirin and clopidogrel in clinical practice: a gastrointestinal perspective. J Gastroenterol (2015) 0.76
Improving on our goal to reduce NSAID-induced GI complications: a challenging task? Am J Gastroenterol (2008) 0.76
Drug-related damage of the ageing gastrointestinal tract. Best Pract Res Clin Gastroenterol (2009) 0.76
Celecoxib versus diclofenac and omeprazole to prevent recurrent ulcer bleeding. N Engl J Med (2003) 0.75
Compliance with prescriptions of appropriate therapy for nonsteroidal anti-inflammatory drug users: is the glass half empty or half full? Clin Gastroenterol Hepatol (2013) 0.75
Medical Treatment of Diverticular Disease: Antibiotics. J Clin Gastroenterol (2016) 0.75
[Gastroprotection in the patient of advanced age: When and how]. Rev Esp Geriatr Gerontol (2012) 0.75
Should prophylactic low-dose aspirin therapy be continued in peptic ulcer bleeding? Drugs (2011) 0.75
[Gastrointestinal and cardiovascular side effects associated with COX-2 selective inhibitors]. Med Clin (Barc) (2002) 0.75
Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene. Dig Dis Sci (2002) 0.75
Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse. J Clin Gastroenterol (2002) 0.75
[Screening for adenocarcinoma in Barrett's esophagus: yes or no, when and how?]. Gastroenterol Hepatol (2013) 0.75
[Unmet needs in the approach to irritable bowel syndrome]. Gastroenterol Hepatol (2006) 0.75
[Irritable intestine syndrome: a disease with a high social, economic, and health-service load]. Aten Primaria (2006) 0.75
[Risk of gastrointestinal bleeding with aspirin and platelet antiaggregants]. Gastroenterol Hepatol (2008) 0.75
Editorial: Harmful and Beneficial Effect of Aspirin on Gastrointestinal Tract. Curr Pharm Des (2015) 0.75
A Balanced View of Efficacy and Safety of Aspirin in Cardiovascular Diseases. Curr Pharm Des (2015) 0.75
Benefits, problems and alternatives to COX-2 inhibition. Curr Top Med Chem (2005) 0.75
Aspirin: the balance between benefits and harms. Preface. Best Pract Res Clin Gastroenterol (2012) 0.75
[Proton pump inhibitors and clopidogrel in a patient with cardiovascular risk factors: Cardiovascular versus gastrointestinal risk?]. Gastroenterol Hepatol (2009) 0.75
Reply: High Risk of Gastrointestinal Bleeding on Dual Antiplatelet Treatment. J Am Coll Cardiol (2016) 0.75