Published in Tetrahedron on March 27, 2010
Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans. PLoS Negl Trop Dis (2013) 0.82
Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science (1999) 6.37
Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control. PLoS Med (2005) 4.00
Mycobacterium ulcerans disease. Bull World Health Organ (2005) 2.30
Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence. Infect Immun (2003) 2.08
Chiral synthesis via organoboranes. 7. Diastereoselective and enantioselective synthesis of erythro- and threo-.beta.-methylhomoallyl alcohols via enantiomeric (Z)- and (E)-crotylboranes. J Am Chem Soc (1986) 2.05
The inhibitory action of Mycobacterium ulcerans soluble factor on monocyte/T cell cytokine production and NF-kappa B function. J Immunol (1999) 2.03
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F. Infect Immun (2006) 1.91
Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans. Nat Rev Microbiol (2009) 1.77
A convenient and genuine equivalent to HZrCp2Cl generated in situ from ZrCp2Cl2-DIBAL-H. Org Lett (2006) 1.74
A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin. Infect Immun (2005) 1.73
Characterization of a Mycobacterium ulcerans-like infection in a colony of African tropical clawed frogs (Xenopus tropicalis). Comp Med (2004) 1.52
Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone. J Exp Med (2007) 1.48
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep (2008) 1.32
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase. Chembiochem (2005) 1.27
Complete structure of the mycolactones. J Am Chem Soc (2001) 1.27
Stereochemistry of the core structure of the mycolactones. J Am Chem Soc (2001) 1.25
Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry. Chem Commun (Camb) (2005) 1.21
A New Role for Polyketides. Angew Chem Int Ed Engl (2000) 1.17
Total synthesis of the mycolactones. Org Lett (2002) 1.15
Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans. Microb Pathog (2003) 1.13
Structure determination of mycolactone C via total synthesis. Org Lett (2004) 1.07
Stereoselective synthesis of the side chains of mycolactones A and B featuring stepwise double substitutions of 1,1-dibromo-1-alkenes. Angew Chem Int Ed Engl (2006) 1.06
Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study. Infect Immun (2008) 1.06
Construction of pseudo-heterochiral and homochiral di-mu-oxotitanium(Schiff base) dimers and enantioselective epoxidation using aqueous hydrogen peroxide. Angew Chem Int Ed Engl (2005) 1.03
Nerve damage in Mycobacterium ulcerans-infected mice: probable cause of painlessness in buruli ulcer. Am J Pathol (2006) 1.02
trans-hydroalumination/alkylation: one-pot synthesis of trisubstituted allylic alcohols. Org Lett (2006) 0.97
A diacetate ketone-catalyzed asymmetric epoxidation of olefins. J Org Chem (2009) 0.96
Total synthesis and stereochemistry of mycolactone F. J Am Chem Soc (2008) 0.94
Enantioselective epoxidation of conjugated cis-enynes by chiral dioxirane. J Org Chem (2007) 0.94
An N-aryl-substituted oxazolidinone-containing ketone-catalyzed asymmetric epoxidation with hydrogen peroxide as the primary oxidant. J Org Chem (2007) 0.93
Synthesis of the mycolactone core by ring-closing metathesis. Chem Commun (Camb) (2006) 0.90
Total Synthesis of Mycolactones A and B. Tetrahedron (2007) 0.88
Heterogeneity in the stereochemistry of mycolactones isolated from M. marinum: toxins produced by fresh vs. saltwater fish pathogens. Chem Commun (Camb) (2009) 0.82
Synthesis and structure of mycolactone E isolated from frog mycobacterium. Org Lett (2008) 0.81
Titanium-salan-catalyzed asymmetric epoxidation with aqueous hydrogen peroxide as the oxidant. Angew Chem Int Ed Engl (2006) 0.79
Nickel-catalyzed coupling producing (2Z)-2,4-alkadien-1-ols, conversion to (E)-3-alkene-1,2,5-triol derivatives, and synthesis of decarestrictine D. J Org Chem (2007) 0.77
Unified total synthesis of pteriatoxins and their diastereomers. J Am Chem Soc (2006) 2.01
Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389. Cancer Res (2004) 1.81
O-sialylation with N-acetyl-5-n,4-o-carbonyl-protected thiosialoside donors in dichloromethane: facile and selective cleavage of the oxazolidinone ring. J Org Chem (2007) 1.72
Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res (2010) 1.39
Direct chemical synthesis of the beta-mannans: linear and block syntheses of the alternating beta-(1-->3)-beta-(1-->4)-mannan common to Rhodotorula glutinis, Rhodotorula mucilaginosa, and Leptospira biflexa. J Am Chem Soc (2004) 1.38
alpha-selective sialylations at -78 degrees C in nitrile solvents with a 1-adamantanyl thiosialoside. J Org Chem (2007) 1.28
Catalytic Ni/Cr-mediated macrocyclization without use of high-dilution techniques. J Am Chem Soc (2005) 1.22
A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B. J Am Chem Soc (2004) 1.21
Complete stereochemistry of tetrafibricin. Org Lett (2003) 1.19
Application of chiral lanthanide shift reagents for assignment of absolute configuration of alcohols. Org Lett (2004) 1.18
Operationally simple and efficient workup procedure for TBAF-mediated desilylation: application to halichondrin synthesis. Org Lett (2007) 1.16
Total synthesis of the mycolactones. Org Lett (2002) 1.15
Stereochemistry of pteriatoxins A, B, and C. J Am Chem Soc (2006) 1.14
Structure determination of mycolactone C via total synthesis. Org Lett (2004) 1.07
Synthesis of DNA Oligomers Possessing a Covalently Cross-Linked Watson-Crick Base Pair Model Financial support from the National Institutes of Health (Grant: NS 12108) is gratefully acknowledged. Angew Chem Int Ed Engl (2001) 1.06
Macrocyclic ketone analogues of halichondrin B. Bioorg Med Chem Lett (2004) 1.04
Efficient glycosidation of a phenyl thiosialoside donor with diphenyl sulfoxide and triflic anhydride in dichloromethane. Org Lett (2006) 1.04
Broad spectrum preclinical antitumor activity of eribulin (Halaven(R)): optimal effectiveness under intermittent dosing conditions. Anticancer Res (2012) 1.02
A new method for translating the asymmetric Ni/Cr-mediated coupling reactions from stoichiometric to catalytic. Org Lett (2005) 1.02
Further improvement on sulfonamide-based ligand for catalytic asymmetric 2-haloallylation and allylation. Org Lett (2008) 1.01
IMPROVED SYNTHESIS OF 1-BENZENESULFINYL PIPERIDINE AND ANALOGS FOR THE ACTIVATION OF THIOGLYCOSIDES IN CONJUNCTION WITH TRIFLUOROMETHANESULFONIC ANHYDRIDE. J Carbohydr Chem (2005) 1.00
Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: stoichiometric process. Org Lett (2002) 0.99
Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans. Chem Commun (Camb) (2010) 0.99
Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process. Org Lett (2002) 0.97
Dramatic improvement in catalyst loadings and molar ratios of coupling partners for Ni/Cr-mediated coupling reactions: heterobimetallic catalysts. J Am Chem Soc (2009) 0.97
Toolbox approach to the search for effective ligands for catalytic asymmetric Cr-mediated coupling reactions. J Am Chem Soc (2009) 0.96
Attempts to improve the overall stereoselectivity of the Ireland-Claisen rearrangement. Org Lett (2009) 0.96
New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: double-inversion approach. J Am Chem Soc (2009) 0.95
Toward the creation of NMR databases in chiral solvents: bidentate chiral NMR solvents for assignment of the absolute configuration of acyclic secondary alcohols. Org Lett (2002) 0.95
Fe/Cr- and Co/Cr-mediated catalytic asymmetric 2-haloallylations of aldehydes. J Am Chem Soc (2004) 0.95
Iterative Cr-mediated catalytic asymmetric allylation to synthesize syn/syn- and anti/anti-1,3,5-triols. Org Lett (2008) 0.95
Tandem Intramolecular Benzyne-Furan Cycloadditions. Total Synthesis of Vineomycinone B(2) Methyl Ester. Tetrahedron (2007) 0.95
Validation of lanthanide chiral shift reagents for determination of absolute configuration: total synthesis of glisoprenin A. Org Lett (2004) 0.95
Total synthesis and stereochemistry of mycolactone F. J Am Chem Soc (2008) 0.94
Biomimetic macrocycle-forming Diels-Alder reaction of an iminium dienophile: synthetic studies directed toward gymnodimine. Org Lett (2005) 0.93
Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. J Med Chem (2012) 0.90
New catalytic cycle for couplings of aldehydes with organochromium reagents. Org Lett (2004) 0.90
Universal NMR databases for contiguous polyols. J Am Chem Soc (2003) 0.88
Total Synthesis of Mycolactones A and B. Tetrahedron (2007) 0.88
Surprisingly efficient catalytic Cr-mediated coupling reactions. Org Lett (2005) 0.88
Total synthesis and stereochemistry of pinnatoxins B and C. Org Lett (2006) 0.87
New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: reductive cyclization and oxy-Michael cyclization approaches. J Am Chem Soc (2009) 0.87
Structurally simplified macrolactone analogues of halichondrin B. Bioorg Med Chem Lett (2004) 0.86
Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line. Neurosci Lett (2012) 0.85
Catalytic enantioselective Cr-mediated propargylation: application to halichondrin synthesis. Org Lett (2009) 0.85
Total synthesis of halichondrin C. J Am Chem Soc (2011) 0.83
Attempts to assemble a universal NMR database without synthesis of NMR database compounds. Org Lett (2006) 0.83
Aggregation behavior of tetraenoic fatty acids in aqueous solution. Angew Chem Int Ed Engl (2007) 0.82
Heterogeneity in the stereochemistry of mycolactones isolated from M. marinum: toxins produced by fresh vs. saltwater fish pathogens. Chem Commun (Camb) (2009) 0.82
Synthesis and structure of mycolactone E isolated from frog mycobacterium. Org Lett (2008) 0.81
Highly stereoselective and iterative synthesis of alpha-(1-->4)-linked polysaccharides composed of 3-O-methyl-D-mannose. Org Lett (2007) 0.81
Chiral aggregates formed from methylated tetraenoic fatty acids: formation of both antipodes of chiral aggregates from a single enantiomer and time-dependent stereomutation. Org Lett (2007) 0.81
Use of a chiral praseodymium shift reagent in predicting the complete stereostructure of glisoprenin A. Org Lett (2004) 0.80
Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission. Microbes Infect (2012) 0.80
Synthesis and structure assignment of the minor metabolite arising from the frog pathogen Mycobacterium liflandii. Tetrahedron Lett (2010) 0.79
Chlorophyll Catabolism Leading to the Skeleton of Dinoflagellate and Krill Luciferins: Hypothesis and Model Studies Financial support from the National Institutes of Health (NS 12108) is gratefully acknowledged. Angew Chem Int Ed Engl (2001) 0.79
Stereochemistry of sagittamide A: prediction and confirmation. Org Lett (2006) 0.79
On Ni catalysts for catalytic, asymmetric Ni/Cr-mediated coupling reactions. J Am Chem Soc (2012) 0.78
Product-regulation mechanisms for fatty acid biosynthesis catalyzed by Mycobacterium smegmatis FAS I. Chembiochem (2007) 0.77
Effective Procedure for Selective Ammonolysis of Monosubstituted Oxiranes: Application to E7389 Synthesis. Tetrahedron Lett (2007) 0.77
Second generation synthesis of C27-C35 building block of E7389, a synthetic halichondrin analogue. Org Lett (2009) 0.77
Air-stable heterobimetallic catalysts to effect Ni/Cr-mediated couplings with a ca. 1:1 molar ratio of coupling partners at low catalyst loadings. Org Lett (2011) 0.77
Synthetic 6-O-methylglucose-containing polysaccharides (sMGPs): design and synthesis. J Org Chem (2007) 0.76
Synthetic 3-O-methylmannose-containing polysaccharides (sMMPs): design and synthesis. J Org Chem (2007) 0.76
Conformational analysis of a covalently cross-linked Watson-Crick base pair model. Bioorg Med Chem Lett (2008) 0.75
Concise and highly stereoselective synthesis of the C20-C26 building block of halichondrins and Eribulin. Org Lett (2012) 0.75
An Extension of the Meaning Making Model Using Data From Chinese Cancer Patients: The Moderating Effect of Resilience. Psychol Trauma (2017) 0.75
Synthesis and structure of two new mycolactones isolated from M. ulcerans subsp. shinshuense. Org Lett (2012) 0.75
Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents. J Med Chem (2013) 0.75
Synthesis of the C20-C26 building block of halichondrins via a regiospecific and stereoselective S(N)2' reaction. Org Lett (2002) 0.75
Unique reactivity of the Mukaiyama glycosidation catalyst (SnCl3ClO4) toward beta-mannopyranosides. Chem Asian J (2008) 0.75
Complexation of fatty acids and fatty acid-CoAs with synthetic O-methylated polysaccharides. Chembiochem (2007) 0.75
Practical and scalable synthesis of alpha-(1-->4)-linked polysaccharides composed of 6-O-methyl-D-glucose. Org Lett (2007) 0.75
Total synthesis of halichondrin A, the missing member in the halichondrin class of natural products. J Am Chem Soc (2014) 0.75
Synthesis of alcohols from m-fluorophenylsulfones and dialkylboranes: application to the C14-C35 building block of E7389. Org Lett (2012) 0.75
Photochemistry of mycolactone A/B, the causative toxin of Buruli ulcer. J Am Chem Soc (2012) 0.75