Philippe Roche

Author PubWeight™ 19.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression. J Immunol 2005 1.60
2 Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I). Curr Opin Chem Biol 2011 1.49
3 Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein. Proc Natl Acad Sci U S A 2013 1.34
4 Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database. PLoS One 2010 1.29
5 Missense mutations in the homeodomain of HOXD13 are associated with brachydactyly types D and E. Am J Hum Genet 2003 1.29
6 2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions. Nucleic Acids Res 2012 1.25
7 Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse. Semin Immunol 2005 0.88
8 Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase. Mol Pharmacol 2003 0.87
9 Symbiotic and taxonomic diversity of rhizobia isolated from Acacia tortilis subsp. raddiana in Africa. Syst Appl Microbiol 2002 0.85
10 NMR and MD investigations of human galectin-1/oligosaccharide complexes. Biophys J 2009 0.85
11 Modeling study of human renal chloride channel (hCLC-5) mutations suggests a structural-functional relationship. Kidney Int 2003 0.83
12 Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular dynamics. Biochemistry 2010 0.82
13 Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. J Med Chem 2010 0.82
14 2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine. J R Soc Interface 2013 0.80
15 Computational studies of human galectin-1: role of conserved tryptophan residue in stacking interaction with carbohydrate ligands. J Biomol Struct Dyn 2009 0.80
16 Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space. Future Med Chem 2014 0.79
17 An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem 2010 0.79
18 Reply to Jensen and Blackledge: Dual quantifications of intrinsically disordered proteins by NMR ensembles and molecular dynamics simulations. Proc Natl Acad Sci U S A 2014 0.78
19 TM0486 from the hyperthermophilic anaerobe Thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions. J Mol Biol 2010 0.78
20 Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation. J Biol Chem 2012 0.77
21 MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif. FEBS Lett 2011 0.75
22 Stereoselective synthesis of original spirolactams displaying promising folded structures. Org Biomol Chem 2013 0.75