Published in Org Lett on April 16, 2010
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. Curr Opin Chem Biol (2012) 1.15
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc Natl Acad Sci U S A (2011) 1.15
A comprehensive review of glycosylated bacterial natural products. Chem Soc Rev (2015) 1.13
Strain prioritization for natural product discovery by a high-throughput real-time PCR method. J Nat Prod (2014) 1.03
Eurothiocin A and B, sulfur-containing benzofurans from a soft coral-derived fungus Eurotium rubrum SH-823. Mar Drugs (2014) 0.92
A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Mol Biosyst (2015) 0.89
Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. J Nat Prod (2012) 0.87
Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. Bioorg Med Chem (2016) 0.80
Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. Chem Biol (2014) 0.78
Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026. J Ind Microbiol Biotechnol (2016) 0.77
Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine. Biochem Pharmacol (2016) 0.76
Mycemycins A-E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes. Mar Drugs (2015) 0.75
In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin. Bioorg Med Chem (2017) 0.75
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc Natl Acad Sci U S A (2003) 10.30
Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature (2006) 5.81
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A (2007) 2.43
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy. J Am Chem Soc (2006) 1.87
Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity. Angew Chem Int Ed Engl (2007) 1.52
Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrob Agents Chemother (2009) 1.23
Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol (2010) 1.19
Structure and semisynthesis of platensimide A, produced by Streptomyces platensis. Org Lett (2008) 1.07
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity. J Am Chem Soc (2008) 1.06
Adamantaplatensimycin: a bioactive analogue of platensimycin. Angew Chem Int Ed Engl (2007) 1.06
Total synthesis of platensimycin and related natural products. J Am Chem Soc (2009) 0.99
Total synthesis and antibacterial properties of carbaplatensimycin. J Am Chem Soc (2007) 0.97
Synthesis and biological evaluation of platensimycin analogs. Bioorg Med Chem Lett (2009) 0.93
Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin. Chemistry (2009) 0.92
Isoplatensimycin: Synthesis and biological evaluation. Bioorg Med Chem Lett (2009) 0.90
Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg Med Chem Lett (2009) 0.89
Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis. Chem Commun (Camb) (2008) 0.89
Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis (2009) 18.19
Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg (2007) 6.08
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol (2010) 3.44
Decoding human cytomegalovirus. Science (2012) 2.98
In vivo pharmacodynamic activity of daptomycin. Antimicrob Agents Chemother (2004) 2.88
Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proc Natl Acad Sci U S A (2012) 2.79
Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. Antimicrob Agents Chemother (2006) 2.68
Biosynthesis of the enediyne antitumor antibiotic C-1027. Science (2002) 2.53
A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol (2003) 2.41
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proc Natl Acad Sci U S A (2003) 2.40
LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryot Cell (2005) 2.21
Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem Biol (2009) 1.93
Therapeutic drug monitoring of antifungals: pharmacokinetic and pharmacodynamic considerations. Ther Drug Monit (2008) 1.93
Antitumor antibiotics: bleomycin, enediynes, and mitomycin. Chem Rev (2005) 1.91
Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chem Biol (2004) 1.89
Microbial genomics for the improvement of natural product discovery. Curr Opin Microbiol (2006) 1.87
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. J Am Chem Soc (2007) 1.69
Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network. J Clin Microbiol (2009) 1.67
Primary cutaneous cryptococcosis in immunocompetent and immunocompromised hosts. Med Mycol (2003) 1.63
Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother (2008) 1.62
GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Infect Immun (2006) 1.61
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. Chem Biol (2005) 1.61
Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol (2009) 1.56
Development and validation of an in vivo Candida albicans biofilm denture model. Infect Immun (2010) 1.56
Candida albicans biofilm development, modeling a host-pathogen interaction. Curr Opin Microbiol (2006) 1.56
Hsp90 governs dispersion and drug resistance of fungal biofilms. PLoS Pathog (2011) 1.53
Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proc Natl Acad Sci U S A (2003) 1.48
Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene. Antimicrob Agents Chemother (2010) 1.48
Protein binding: do we ever learn? Antimicrob Agents Chemother (2011) 1.46
Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J Am Chem Soc (2005) 1.46
Clinical breakpoints for voriconazole and Candida spp. revisited: review of microbiologic, molecular, pharmacodynamic, and clinical data as they pertain to the development of species-specific interpretive criteria. Diagn Microbiol Infect Dis (2011) 1.42
A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc (2003) 1.42
In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1. J Am Chem Soc (2008) 1.42
Addition of ceftaroline to daptomycin after emergence of daptomycin-nonsusceptible Staphylococcus aureus during therapy improves antibacterial activity. Antimicrob Agents Chemother (2012) 1.40
Autochthonous furuncular myiasis in the United States: case report and literature review. Clin Infect Dis (2003) 1.40
Biosynthesis of enediyne antitumor antibiotics. Curr Top Med Chem (2008) 1.39
Time course global gene expression analysis of an in vivo Candida biofilm. J Infect Dis (2009) 1.39
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc Natl Acad Sci U S A (2007) 1.38
Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140. J Bacteriol (2002) 1.38
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc Natl Acad Sci U S A (2008) 1.36
Beta -1,3 glucan as a test for central venous catheter biofilm infection. J Infect Dis (2007) 1.34
Alcohol dehydrogenase restricts the ability of the pathogen Candida albicans to form a biofilm on catheter surfaces through an ethanol-based mechanism. Infect Immun (2006) 1.33
Eap1p, an adhesin that mediates Candida albicans biofilm formation in vitro and in vivo. Eukaryot Cell (2007) 1.32
Reply to Oude Lashof and Vogelaers. Clin Infect Dis (2013) 1.30
Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. J Am Chem Soc (2005) 1.25
Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. J Am Chem Soc (2005) 1.24
C-O bond formation by polyketide synthases. Science (2002) 1.23
Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect Immun (2005) 1.23
Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrob Agents Chemother (2009) 1.23
Safety and outcomes of open-label deferasirox iron chelation therapy for mucormycosis. Antimicrob Agents Chemother (2009) 1.21
The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis. J Am Chem Soc (2008) 1.21
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Mol Biosyst (2006) 1.20
Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol (2010) 1.19
Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Biochemistry (2003) 1.16
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. Curr Opin Chem Biol (2012) 1.15
Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. Biochemistry (2003) 1.15
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc Natl Acad Sci U S A (2011) 1.15
Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. J Am Chem Soc (2005) 1.14
The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. J Am Chem Soc (2006) 1.13
Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes. Proc Natl Acad Sci U S A (2010) 1.13
Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. Org Lett (2011) 1.12
Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. J Nat Prod (2006) 1.11
Engineered production of iso-migrastatin in heterologous Streptomyces hosts. Bioorg Med Chem (2008) 1.11
A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis. Proc Natl Acad Sci U S A (2009) 1.11
Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. J Am Chem Soc (2007) 1.11
Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method. Antimicrob Agents Chemother (2008) 1.11
Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opin Drug Discov (2006) 1.10
Voriconazole use for endemic fungal infections. Antimicrob Agents Chemother (2009) 1.10
Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine. J Am Chem Soc (2006) 1.10
Radical-mediated enzymatic carbon chain fragmentation-recombination. Nat Chem Biol (2011) 1.09
CNS pharmacokinetics of antifungal agents. Expert Opin Drug Metab Toxicol (2007) 1.09
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorg Med Chem Lett (2008) 1.08
iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. J Biol Chem (2009) 1.08
The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry (2007) 1.08
Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. J Bacteriol (2008) 1.07
HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production. Fungal Genet Biol (2009) 1.07
Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus. Antimicrob Agents Chemother (2013) 1.07
Signal mimics derived from a metagenomic analysis of the gypsy moth gut microbiota. Appl Environ Microbiol (2007) 1.06
Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry. Anal Biochem (2011) 1.06
Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations. Antimicrob Agents Chemother (2012) 1.06
Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther (2009) 1.05
Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. J Am Chem Soc (2009) 1.04
Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. Chembiochem (2004) 1.04
Strain prioritization for natural product discovery by a high-throughput real-time PCR method. J Nat Prod (2014) 1.03