PubRank

Thomas C Spelsberg

Author PubWeight™ 72.36‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol 2006 2.95
2 Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 2002 2.93
3 The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res 2009 1.94
4 Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 2005 1.88
5 Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta. J Cell Biochem 2003 1.76
6 Hypercholesterolemic aortic-valve disease. N Engl J Med 2003 1.71
7 TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol 2005 1.56
8 TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene 2002 1.53
9 Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells. Mol Endocrinol 2005 1.48
10 Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res 2003 1.42
11 Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Endocrinology 2003 1.28
12 Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. J Biol Chem 2002 1.25
13 Role of TIEG1 in biological processes and disease states. J Cell Biochem 2007 1.23
14 Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. J Bone Miner Res 2005 1.23
15 Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem 2009 1.22
16 Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J Cell Biochem 2002 1.22
17 Coprescription of tamoxifen and medications that inhibit CYP2D6. J Clin Oncol 2010 1.21
18 TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture. Bone 2006 1.18
19 Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation. Circulation 2005 1.18
20 Dose-response of estrogen on bone versus the uterus in ovariectomized mice. Eur J Endocrinol 2004 1.16
21 Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats). J Biol Chem 2008 1.14
22 Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER alpha cells: bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization. J Cell Biochem 2002 1.12
23 TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway. J Cell Biochem 2007 1.06
24 Estrogen receptor alpha/beta isoforms, but not betacx, modulate unique patterns of gene expression and cell proliferation in Hs578T cells. J Cell Biochem 2007 1.05
25 Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res 2011 1.05
26 Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. J Cell Biochem 2008 1.04
27 Functional role of KLF10 in multiple disease processes. Biofactors 2010 1.01
28 Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain. Mol Endocrinol 2008 1.00
29 Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver. Mol Cell Biol 2010 1.00
30 Age-dependent changes in the mechanical properties of tail tendons in TGF-beta inducible early gene-1 knockout mice. J Appl Physiol (1985) 2006 0.98
31 Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol 2005 0.97
32 Atorvastatin decreases cellular proliferation and bone matrix expression in the hypercholesterolemic mitral valve. J Am Coll Cardiol 2005 0.97
33 Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue. Breast Cancer Res Treat 2004 0.96
34 Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem Biophys Res Commun 2010 0.96
35 TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways. PLoS One 2011 0.95
36 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. Int J Cancer 2003 0.93
37 Effects of loss of classical estrogen response element signaling on bone in male mice. Endocrinology 2007 0.93
38 Bone growth and turnover in progesterone receptor knockout mice. Endocrinology 2008 0.93
39 Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth. J Immunol 2011 0.92
40 17beta-estradiol-dependent activation of signal transducer and activator of transcription-1 in human fetal osteoblasts is dependent on Src kinase activity. Endocrinology 2004 0.92
41 Primer on medical genomics. Part III: Microarray experiments and data analysis. Mayo Clin Proc 2002 0.91
42 Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. J Biol Chem 2006 0.91
43 TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization. Blood 2011 0.91
44 Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens. PLoS One 2013 0.91
45 Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody. J Cell Biochem 2012 0.90
46 Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts. J Bone Miner Res 2002 0.88
47 Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2. J Biol Chem 2009 0.88
48 TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts. PLoS One 2011 0.88
49 Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells. J Cell Biochem 2008 0.87
50 Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue. Breast Cancer Res Treat 2002 0.85
51 ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer. BMC Cancer 2014 0.84
52 Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens. J Steroid Biochem Mol Biol 2005 0.83
53 Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation. BMC Musculoskelet Disord 2010 0.83
54 Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages. Eur J Immunol 2012 0.82
55 Distribution of estrogen receptors alpha and beta mRNA in mouse urogenital tissues and their expression after oophorectomy and estrogen replacement. Int Urogynecol J Pelvic Floor Dysfunct 2003 0.81
56 TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy. J Cell Biochem 2012 0.80
57 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells. J Cell Biochem 2010 0.80
58 Molecular structure of tail tendon fibers in TIEG1 knockout mice using synchrotron diffraction technology. J Appl Physiol (1985) 2010 0.79
59 TIEG1-NULL OSTEOCYTES DISPLAY DEFECTS IN THEIR MORPHOLOGY, DENSITY AND SURROUNDING BONE MATRIX. J Musculoskelet Res 2009 0.79
60 TGFβ inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton. J Bone Miner Res 2014 0.79
61 P2X(3) receptor subunit messenger RNA expression in the female mouse bladder after oophorectomy with or without estrogen replacement. Am J Obstet Gynecol 2002 0.78
62 Primer on medical genomics. Part IV: Expression proteomics. Mayo Clin Proc 2002 0.78
63 TIEG1-null tenocytes display age-dependent differences in their gene expression, adhesion, spreading and proliferation properties. Exp Cell Res 2011 0.77
64 Mitral valve disease in a patient with familial hypercholesterolemia. Rev Port Cardiol 2010 0.77
65 A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites. Bone 2010 0.75
66 WOUND-HEALING PROPERTIES OF TRANSFORMING GROWTH FACTOR β (TGF-β) INDUCIBLE EARLY GENE 1 (TIEG1) KNOCKOUT MICE. J Musculoskelet Res 2008 0.75
67 Primer on medical genomics part II: Background principles and methods in molecular genetics. Mayo Clin Proc 2002 0.75
68 Primer on medical genomics. The end of the beginning. Mayo Clin Proc 2004 0.75