Published in J Med Chem on April 22, 2010
A review of ceramide analogs as potential anticancer agents. Future Med Chem (2013) 0.92
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett (2011) 0.81
4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med Chem Lett (2011) 0.79
S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. J Pharmacol Exp Ther (2016) 0.75
Cardiac Effects of Amiselimod Compared with Fingolimod and Placebo: Results of a Randomised, Parallel-group, Phase I Study in Healthy Subjects. Br J Clin Pharmacol (2016) 0.75
Sphingosine 1-Phosphate Receptors: Do They Have a Therapeutic Potential in Cardiac Fibrosis? Front Pharmacol (2017) 0.75
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. Blood (2010) 1.77
FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol (2005) 1.74
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood (2004) 1.62
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun (2002) 1.62
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent. J Natl Cancer Inst (2004) 1.55
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J Immunol (2006) 1.43
Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol Immunol (2006) 1.35
Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation. J Nucl Med (2002) 1.30
Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes. Proc Natl Acad Sci U S A (2009) 1.28
In vivo real-time, multicolor, quantum dot lymphatic imaging. J Invest Dermatol (2009) 1.26
Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic. Proc Natl Acad Sci U S A (2008) 1.21
Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography. Magn Reson Med (2003) 1.18
The efficacy and safety of blonanserin compared with haloperidol in acute-phase schizophrenia: a randomized, double-blind, placebo-controlled, multicentre study. CNS Drugs (2009) 1.18
Diffusion abnormalities of the uncinate fasciculus in Alzheimer's disease: diffusion tensor tract-specific analysis using a new method to measure the core of the tract. Neuroradiology (2008) 1.17
Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies. J Immunol Methods (2009) 1.15
Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab (2007) 1.11
Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3. J Biol Chem (2003) 1.08
Cortical hypometabolism and hypoperfusion in Parkinson's disease is extensive: probably even at early disease stages. Brain Struct Funct (2010) 1.07
Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth. J Nat Med (2011) 1.06
DBC2 is essential for transporting vesicular stomatitis virus glycoprotein. J Mol Biol (2006) 1.04
Brachial and lumbar plexuses in chronic inflammatory demyelinating polyradiculoneuropathy: MRI assessment including apparent diffusion coefficient. Neuroradiology (2010) 1.04
Domain structure of bi-functional selenoprotein P. Biochem J (2004) 1.00
Contribution of subtraction ictal SPECT coregistered to MRI to epilepsy surgery: a multicenter study. Ann Nucl Med (2009) 0.99
MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images: is it useful for differentiation from medulloblastoma? Neuroradiology (2006) 0.98
MRI, MR spectroscopy, and diffusion tensor imaging findings in patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA). Brain Dev (2012) 0.98
Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J Immunol (2004) 0.98
Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients. J Atheroscler Thromb (2014) 0.96
Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis. Int Immunopharmacol (2010) 0.96
Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. Cell Mol Immunol (2006) 0.96
Degeneration of dementia with Lewy bodies measured by diffusion tensor imaging. NMR Biomed (2009) 0.95
Clinical and imaging characteristics of localized megalencephaly: a retrospective comparison of diffuse hemimegalencephaly and multilobar cortical dysplasia. Neuroradiology (2009) 0.95
Relationship between diffusion tensor imaging and brain morphology in patients with myotonic dystrophy. Neurosci Lett (2006) 0.94
Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent. Kidney Int (2002) 0.94
Identification of a potent and orally active non-peptide C5a receptor antagonist. J Biol Chem (2002) 0.93
DNA methylation profiling of embryonic stem cell differentiation into the three germ layers. PLoS One (2011) 0.93
Spontaneous poorly differentiated carcinoma with cells positive for vimentin in a salivary gland of a young rat. Toxicol Pathol (2010) 0.93
Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. Int Immunol (2010) 0.93
Identification and characterization of a Xenopus homolog of Dbf4, a regulatory subunit of the Cdc7 protein kinase required for the initiation of DNA replication. J Biochem (2003) 0.93
Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr (2005) 0.92
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle. Neoplasia (2005) 0.92
Small-molecule diversity using a skeletal transformation strategy. Org Lett (2005) 0.91
In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8 plus DARTEL for VBM. Neuroimage Clin (2013) 0.90
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg Med Chem (2005) 0.90
Diffuse cerebral hypomyelination with cerebellar atrophy and hypoplasia of the corpus callosum. Brain Dev (2008) 0.90
C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease. J Gastroenterol (2013) 0.90
Increased number of subcortical hyperintensities on MRI in children and adolescents with Tourette's syndrome, obsessive-compulsive disorder, and attention deficit hyperactivity disorder. Am J Psychiatry (2006) 0.89
Image Fusion System Using PACS for MRI, CT, and PET Images. Clin Positron Imaging (1999) 0.89
A monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen, on the carbohydrate moiety of mucin. FEBS J (2007) 0.89
Prepulse inhibition of acoustic startle response in mild cognitive impairment and mild dementia of Alzheimer type. Psychiatry Clin Neurosci (2006) 0.88
Function and practice of public health nursing in Japan: a trial to develop the Japanese Purpose-Focused Public Health Nursing Model. J Nurs Manag (2006) 0.88
Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification. Neoplasia (2003) 0.88
Normal cranial nerves in the cavernous sinuses: contrast-enhanced three-dimensional constructive interference in the steady state MR imaging. AJNR Am J Neuroradiol (2005) 0.87
Diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in Alzheimer's disease. Magn Reson Imaging (2008) 0.87
Occurrence of an alpha-galacturonosyl-ceramide in the dioxin-degrading bacterium Sphingomonas wittichii. FEMS Microbiol Lett (2002) 0.87
Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression. J Neuropathol Exp Neurol (2012) 0.87
Serous surface papillary carcinoma of the peritoneum: clinical, radiologic, and pathologic findings in 11 patients. AJR Am J Roentgenol (2004) 0.86
Relationship between apathy and diffusion tensor imaging metrics of the brain in Alzheimer's disease. Int J Geriatr Psychiatry (2011) 0.86
New dinapinone derivatives, potent inhibitors of triacylglycerol synthesis in mammalian cells, produced by Talaromyces pinophilus FKI-3864. J Antibiot (Tokyo) (2013) 0.86
Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: tract-specific analysis. Radiat Med (2008) 0.86
Effects of central administration of glucagon on feed intake and endocrine responses in sheep. Anim Sci J (2009) 0.85
Confirmation of the anomeric structure of galacturonic acid in the galacturonosyl-ceramide of Sphingomonas yanoikuyae. Microbiol Immunol (2006) 0.85
Design and synthesis of orally active benzamide derivatives as potent serotonin 4 receptor agonist. Bioorg Med Chem (2003) 0.85
Increased serum iron may contribute to enhanced oxidation of low-density lipoprotein in smokers in part through changes in lipoxygenase and catalase. Clin Chim Acta (2004) 0.85
Relaxing effect and mechanism of tafluprost on isolated rabbit ciliary arteries. Exp Eye Res (2008) 0.85
Intravenous administration of amino acids during anesthesia stimulates muscle protein synthesis and heat accumulation in the body. Am J Physiol Endocrinol Metab (2005) 0.84
Selection and analysis of anti-cancer antibodies for cancer therapy obtained from antibody phage library. Cancer Sci (2010) 0.84
Central administration of somatostatin stimulates feeding behavior in chicks. Gen Comp Endocrinol (2009) 0.84
Effects of prostaglandin F(2α) analogues on endothelin-1-induced impairment of rabbit ocular blood flow: comparison among tafluprost, travoprost, and latanoprost. Exp Eye Res (2010) 0.84
BART is essential for nuclear retention of STAT3. Int Immunol (2008) 0.84
Infliximab therapy for intestinal, neurological, and vascular involvement in Behcet disease: Efficacy, safety, and pharmacokinetics in a multicenter, prospective, open-label, single-arm phase 3 study. Medicine (Baltimore) (2016) 0.83
Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: an analysis of Japanese clinical trials of infliximab. J Dermatol (2011) 0.83
Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate. J Nutr Sci Vitaminol (Tokyo) (2004) 0.83
Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis. Future Med Chem (2012) 0.83
Circulating Interleukin 6 and Albumin, and Infliximab Levels Are Good Predictors of Recovering Efficacy After Dose Escalation Infliximab Therapy in Patients with Loss of Response to Treatment for Crohn's Disease: A Prospective Clinical Trial. Inflamm Bowel Dis (2015) 0.83
Central administration of insulin suppresses food intake in chicks. Neurosci Lett (2007) 0.83
Serotonin transporter gene polymorphism and BPSD in mild Alzheimer's disease. J Alzheimers Dis (2007) 0.83
Effect of bacterial flora on postimmunization gastritis following oral vaccination of mice with Helicobacter pylori heat shock protein 60. Clin Diagn Lab Immunol (2003) 0.83
Usefulness of SWI for the Detection of Iron in the Motor Cortex in Amyotrophic Lateral Sclerosis. J Neuroimaging (2014) 0.83
Comparison of SPM and NEUROSTAT in voxelwise statistical analysis of brain SPECT and MRI at the early stage of Alzheimer's disease. Ann Nucl Med (2009) 0.82
Central administration of neuromedin U suppresses food intake in chicks. Neurosci Lett (2007) 0.82
Differential dose response of mTOR signaling to oral administration of leucine in skeletal muscle and liver of rats. Biosci Biotechnol Biochem (2013) 0.82
Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom. Med Phys (2013) 0.82
Salmonella meningitis: a report from National Hue Central Hospital, Vietnam. Jpn J Infect Dis (2014) 0.82
Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor. Biochem Biophys Res Commun (2003) 0.82
Induction of nephrotoxic serum nephritis in inbred mice and suppressive effect of colchicine on the development of this nephritis. Pharmacol Res (2002) 0.82
Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists. Bioorg Med Chem (2004) 0.82
Added value of contrast-enhanced CISS imaging in relation to conventional MR images for the evaluation of intracavernous cranial nerve lesions. Neuroradiology (2010) 0.81
An RNA biding protein, Y14 interacts with and modulates STAT3 activation. Biochem Biophys Res Commun (2008) 0.81