| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The challenges of Chagas Disease-- grim outlook or glimmer of hope.
|
PLoS Med
|
2007
|
2.79
|
|
2
|
Chemotherapy of trypanosomiases and leishmaniasis.
|
Trends Parasitol
|
2005
|
2.37
|
|
3
|
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
|
J Med Chem
|
2006
|
1.98
|
|
4
|
Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus.
|
Am J Trop Med Hyg
|
2010
|
1.77
|
|
5
|
Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.
|
Antimicrob Agents Chemother
|
2002
|
1.45
|
|
6
|
Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.
|
Int J Parasitol Drugs Drug Resist
|
2012
|
1.15
|
|
7
|
Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi.
|
Int J Antimicrob Agents
|
2004
|
1.10
|
|
8
|
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
|
PLoS Negl Trop Dis
|
2013
|
1.10
|
|
9
|
Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate.
|
J Infect Dis
|
2002
|
1.10
|
|
10
|
Eliminating Chagas disease: challenges and a roadmap.
|
BMJ
|
2009
|
1.06
|
|
11
|
Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition.
|
Protist
|
2007
|
1.06
|
|
12
|
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.
|
Antimicrob Agents Chemother
|
2007
|
1.05
|
|
13
|
Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis.
|
Mol Biol Int
|
2011
|
1.03
|
|
14
|
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts.
|
Antimicrob Agents Chemother
|
2004
|
1.01
|
|
15
|
Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.
|
Int J Antimicrob Agents
|
2004
|
1.00
|
|
16
|
In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.
|
Antimicrob Agents Chemother
|
2008
|
1.00
|
|
17
|
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
|
Int J Antimicrob Agents
|
2010
|
0.99
|
|
18
|
Quinuclidine derivatives as potential antiparasitics.
|
Antimicrob Agents Chemother
|
2007
|
0.99
|
|
19
|
Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis.
|
J Antimicrob Chemother
|
2005
|
0.99
|
|
20
|
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible.
|
FEBS Lett
|
2002
|
0.98
|
|
21
|
Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi.
|
Int J Antimicrob Agents
|
2012
|
0.98
|
|
22
|
Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitor of squalene synthase, on Leishmania amazonensis.
|
Exp Parasitol
|
2005
|
0.97
|
|
23
|
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
|
Antimicrob Agents Chemother
|
2007
|
0.96
|
|
24
|
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
|
Antimicrob Agents Chemother
|
2005
|
0.94
|
|
25
|
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors.
|
Int J Antimicrob Agents
|
2006
|
0.94
|
|
26
|
Benznidazole for Chronic Chagas' Cardiomyopathy.
|
N Engl J Med
|
2016
|
0.93
|
|
27
|
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
|
J Med Chem
|
2006
|
0.93
|
|
28
|
Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in vitro.
|
J Antimicrob Chemother
|
2006
|
0.92
|
|
29
|
Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
|
J Biol Chem
|
2007
|
0.92
|
|
30
|
The glycosome membrane of Trypanosoma cruzi epimastigotes: protein and lipid composition.
|
Exp Parasitol
|
2004
|
0.91
|
|
31
|
Effects of sterol biosynthesis inhibitors on endosymbiont-bearing trypanosomatids.
|
FEMS Microbiol Lett
|
2006
|
0.89
|
|
32
|
Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro.
|
Antimicrob Agents Chemother
|
2010
|
0.88
|
|
33
|
Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi.
|
Int J Antimicrob Agents
|
2004
|
0.87
|
|
34
|
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.
|
Antimicrob Agents Chemother
|
2006
|
0.87
|
|
35
|
New advances in the management of a long-neglected disease.
|
Clin Infect Dis
|
2009
|
0.86
|
|
36
|
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.
|
Antimicrob Agents Chemother
|
2008
|
0.86
|
|
37
|
Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.
|
Int J Parasitol
|
2012
|
0.85
|
|
38
|
Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors.
|
Vet Parasitol
|
2007
|
0.84
|
|
39
|
Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii.
|
Int J Antimicrob Agents
|
2005
|
0.83
|
|
40
|
Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms.
|
BMC Microbiol
|
2009
|
0.83
|
|
41
|
Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action.
|
Bioorg Med Chem
|
2007
|
0.81
|
|
42
|
Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
|
J Antimicrob Chemother
|
2009
|
0.81
|
|
43
|
Selective anti-Toxoplasma gondii activities of azasterols.
|
Int J Antimicrob Agents
|
2004
|
0.80
|
|
44
|
Ultrastructural alterations induced by Δ(24(25))-sterol methyltransferase inhibitors on Trichomonas vaginalis.
|
FEMS Microbiol Lett
|
2010
|
0.79
|
|
45
|
Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.
|
Ann Clin Microbiol Antimicrob
|
2011
|
0.78
|
|
46
|
Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B.
|
J Infect Chemother
|
2011
|
0.76
|
|
47
|
Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.
|
Mol Biochem Parasitol
|
2011
|
0.75
|
|
48
|
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole.
|
J Am Coll Cardiol
|
2017
|
0.75
|
|
49
|
The effect of 3-(biphenyl-4-yl)-3-hydoxyquinuclidine (BPQ-OH) and metronidazole on Trichomonas vaginalis: a comparative study.
|
Parasitol Res
|
2014
|
0.75
|