Published in Blood on March 29, 2010
miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Dis (2012) 1.40
Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. Mol Cancer Ther (2013) 1.21
Significant biological role of sp1 transactivation in multiple myeloma. Clin Cancer Res (2011) 1.07
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8. EMBO Rep (2012) 1.07
Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease. Proc Natl Acad Sci U S A (2011) 1.06
Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors. J Biomed Biotechnol (2011) 1.03
Cancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy. Haematologica (2011) 1.00
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. J Biol Chem (2013) 0.97
Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. Invest New Drugs (2011) 0.97
KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells. Blood (2011) 0.93
Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia. Leukemia (2013) 0.92
Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma. Epigenetics (2014) 0.89
Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. J Clin Invest (2013) 0.89
The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem (2013) 0.89
The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma. Ther Adv Hematol (2014) 0.88
Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response. Cancer Lett (2013) 0.86
HDAC inhibitor L-carnitine and proteasome inhibitor bortezomib synergistically exert anti-tumor activity in vitro and in vivo. PLoS One (2012) 0.86
Proteasome and HDAC: who's zooming who? Blood (2010) 0.86
The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1. J Biol Chem (2016) 0.84
Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma. J Clin Invest (2015) 0.82
Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk. Oncotarget (2015) 0.82
Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding. PLoS One (2013) 0.79
Clinical use and applications of histone deacetylase inhibitors in multiple myeloma. Clin Pharmacol (2016) 0.78
Identification of Synergistic, Clinically Achievable, Combination Therapies for Osteosarcoma. Sci Rep (2015) 0.78
Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model. Leukemia (2014) 0.77
Lenalidomide and vorinostat maintenance after autologous transplant in multiple myeloma. Br J Haematol (2015) 0.77
Rational Combinations of Targeted Agents in AML. J Clin Med (2015) 0.76
A phase II study of belinostat (PXD101) in relapsed and refractory aggressive B-cell lymphomas: SWOG S0520. Leuk Lymphoma (2016) 0.76
Overview of Histone Deacetylase Inhibitors in Haematological Malignancies. Pharmaceuticals (Basel) (2010) 0.76
The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective. Adv Ther (2016) 0.75
Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors. Oncotarget (2016) 0.75
A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration. Oncotarget (2016) 0.75
Use of class I histone deacetylase inhibitor romidepsin in combination regimens. Leuk Lymphoma (2016) 0.75
Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics. Pharmaceuticals (Basel) (2017) 0.75
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80
Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation – the J-ROCKET AF study –. Circ J (2012) 3.70
Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood (2006) 3.52
Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke Trial. Stroke (2005) 2.56
Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma. Blood (2006) 2.18
Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques. J Clin Invest (2012) 2.11
Evaluation of the impact of atrial fibrillation on rehospitalization events in heart failure patients in recent years. J Cardiol (2012) 2.00
A national survey on myocarditis associated with the 2009 influenza A (H1N1) pandemic in Japan. Circ J (2010) 1.79
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors. Mol Cell Biol (2004) 1.74
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. Intern Med (2005) 1.71
A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease. Mol Ther (2010) 1.68
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci (2004) 1.65
Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis. J Am Coll Cardiol (2004) 1.57
Prognostic utility of B-type natriuretic peptide assessment in stable low-risk outpatients with nonischemic cardiomyopathy after decompensated heart failure. J Am Coll Cardiol (2008) 1.52
Depsipeptide-resistant KU812 cells show reversible P-glycoprotein expression, hyper-acetylated histones, and modulated gene expression profile. Leuk Res (2005) 1.52
Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Hum Gene Ther (2010) 1.51
Engraftment and tumor formation after allogeneic in utero transplantation of primate embryonic stem cells. Transplantation (2003) 1.51
Hemodialysis is an independent predictor of coronary in-stent restenosis after paclitaxel eluting stent implantation. Intern Med (2010) 1.46
Intensively lowering both low-density lipoprotein cholesterol and blood pressure does not reduce cardiovascular risk in Japanese coronary artery disease patients. Circ J (2011) 1.45
Two cases of Brugada syndrome associated with spontaneous clinical episodes of coronary vasospasm. Intern Med (2006) 1.45
rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse. Biochem Biophys Res Commun (2006) 1.45
Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J Neurosci (2002) 1.45
Angiotensin II-mediated up-regulation of connective tissue growth factor promotes atrial tissue fibrosis in the canine atrial fibrillation model. Europace (2012) 1.45
The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in Japan. Eur J Haematol (2009) 1.44
Effect of hypothermia therapy after outpatient cardiac arrest due to ventricular fibrillation. Circ J (2009) 1.41
Mutant macaque factor IX T262A: a tool for hemophilia B gene therapy studies in macaques. Thromb Res (2010) 1.41
Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Eur J Haematol (2007) 1.41
Phosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction. Circ J (2012) 1.40
Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol (2003) 1.39
Cardiomyocyte-derived mitochondrial superoxide causes myocardial electrical remodeling by downregulating potassium channels and related molecules. Circ J (2014) 1.39
Efficacy and safety of tolvaptan in heart failure patients with volume overload despite the standard treatment with conventional diuretics: a phase III, randomized, double-blind, placebo-controlled study (QUEST study). Cardiovasc Drugs Ther (2011) 1.37
A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells. J Biol Chem (2002) 1.37
Sympathetic nervous activity and myocardial damage immediately after subarachnoid hemorrhage in a unique animal model. Stroke (2002) 1.35
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria. J Biomed Sci (2002) 1.29
Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes. Hum Gene Ther (2009) 1.29
Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure. Circ J (2008) 1.27
Development of new inbred transgenic strains of rats with LacZ or GFP. Biochem Biophys Res Commun (2005) 1.24
Apaf-1 is a mediator of E2F-1-induced apoptosis. J Biol Chem (2002) 1.23
Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. Leuk Lymphoma (2007) 1.22
Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res (2007) 1.18
Cloning and characterization of novel snake venom proteins that block smooth muscle contraction. Eur J Biochem (2002) 1.16
Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice. Circulation (2009) 1.16
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab (2009) 1.16
Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther (2002) 1.15
FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia. Blood (2010) 1.14
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells. J Virol (2006) 1.13
Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin signaling. J Cell Physiol (2003) 1.12
Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med (2009) 1.10
Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. J Biol Chem (2001) 1.10
Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum (2005) 1.10
Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation. Cytotherapy (2010) 1.09
Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector. Mol Ther (2005) 1.07
Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease. Cardiovasc Diabetol (2010) 1.07
Circulating levels of interleukin 18 reflect etiologies of heart failure: Th1/Th2 cytokine imbalance exaggerates the pathophysiology of advanced heart failure. J Card Fail (2002) 1.07
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8. EMBO Rep (2012) 1.07
Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. J Virol (2006) 1.07
Expression levels of histone deacetylases determine the cell fate of hematopoietic progenitors. J Biol Chem (2009) 1.07
Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res (2005) 1.07
NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites. Cancer Res (2012) 1.06
Repair of infarcted myocardium mediated by transplanted bone marrow-derived CD34+ stem cells in a nonhuman primate model. Stem Cells (2005) 1.06
Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses. Hum Gene Ther (2002) 1.05
A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression. Blood (2002) 1.04
A functional role of Stat3 in in vivo megakaryopoiesis. Blood (2002) 1.04
Successful gene transfer using adeno-associated virus vectors into the kidney: comparison among adeno-associated virus serotype 1-5 vectors in vitro and in vivo. Nephron Exp Nephrol (2004) 1.04
Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group. Haematologica (2008) 1.04
Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer. Cancer Res (2003) 1.02
Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease. Mol Ther (2005) 1.02
Transcriptional modulation using HDACi depsipeptide promotes immune cell-mediated tumor destruction of murine B16 melanoma. J Invest Dermatol (2008) 1.00
Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA Collaborative Study Group. Am J Hematol (2009) 1.00
Mesenchymal stromal cells for graft-versus-host disease : basic aspects and clinical outcomes. J Clin Exp Hematop (2010) 1.00
Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand. Cancer Sci (2007) 1.00
Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma. Br J Haematol (2003) 0.99
Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors. Cancer Sci (2008) 0.99
Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates. Exp Hematol (2009) 0.99
Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats. J Gene Med (2008) 0.99
Mechanisms of immunomodulation by mesenchymal stem cells. Int J Hematol (2007) 0.99
ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412. Biochem Biophys Res Commun (2012) 0.98
Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport. Neurosci Res (2003) 0.97
Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters. Proc Natl Acad Sci U S A (2002) 0.97
Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression. Mol Ther (2006) 0.97
Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemia. Lipids Health Dis (2009) 0.97
Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes. Int J Hematol (2008) 0.96
Primary cardiac osteosarcoma in a young man with severe congestive heart failure. Intern Med (2007) 0.96
Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors. Mol Ther (2012) 0.96
Phase III clinical pharmacology study of tolvaptan. Cardiovasc Drugs Ther (2011) 0.96
Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group. Haematologica (2008) 0.96
Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line. Exp Hematol (2004) 0.95
Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem Biophys Res Commun (2006) 0.95
AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb ischemia model. Cardiovasc Res (2002) 0.95
Clinical significance of corticosteroid therapy for eosinophilic myocarditis. Int Heart J (2011) 0.94