Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.

PubWeight™: 1.31‹?› | Rank: Top 10%

🔗 View Article (PMID 20357131)

Published in J Neurosci on March 31, 2010

Authors

Hitoshi Uchida1, Lin Ma, Hiroshi Ueda

Author Affiliations

1: Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8521, Japan.

Associated clinical trials:

Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery | NCT04031716

Articles citing this

Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med (2011) 2.17

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain (2011) 1.87

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med (2011) 1.50

Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain? Mol Pain (2011) 1.23

Chronic pain: emerging evidence for the involvement of epigenetics. Neuron (2012) 1.21

Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Mol Pain (2010) 1.19

Opening paths to novel analgesics: the role of potassium channels in chronic pain. Trends Neurosci (2014) 1.16

Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability. J Neurosci (2010) 1.07

Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury. Eur J Pain (2011) 1.06

Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory. Neurobiol Learn Mem (2013) 0.98

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife (2014) 0.96

Epigenetic regulation of chronic pain. Epigenomics (2015) 0.93

Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. Mol Pain (2014) 0.91

Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity. Neuropharmacology (2014) 0.90

The nuclear events guiding successful nerve regeneration. Front Mol Neurosci (2011) 0.89

Epigenetic mechanisms of chronic pain. Trends Neurosci (2015) 0.89

Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system. Gastroenterology (2014) 0.88

Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II). Med Sci Monit (2014) 0.85

Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J Biol Chem (2012) 0.84

Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol (2013) 0.84

Pharmacogenetics of analgesic drugs. Br J Pain (2013) 0.83

Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons. J Biol Chem (2016) 0.83

HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. Br J Pharmacol (2013) 0.82

Increased expression of sodium channel subunit Nav1.1 in the injured dorsal root ganglion after peripheral nerve injury. Anat Rec (Hoboken) (2011) 0.81

Understanding neurological disease mechanisms in the era of epigenetics. JAMA Neurol (2013) 0.81

Epigenetic regulation of persistent pain. Transl Res (2014) 0.80

Eradicating the mediators of neuronal death with a fine-tooth comb. Sci Signal (2010) 0.80

Spinal SIRT1 activation attenuates neuropathic pain in mice. PLoS One (2014) 0.80

NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice. Mol Brain (2015) 0.80

Contribution of the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve Injury-induced Nociceptive Hypersensitivity. Anesthesiology (2016) 0.79

Expression of DNA methyltransferases in adult dorsal root ganglia is cell-type specific and up regulated in a rodent model of neuropathic pain. Front Cell Neurosci (2014) 0.79

μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice. PLoS One (2013) 0.79

G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury. Mol Pain (2016) 0.78

Are Epigenetic Factors Implicated in Chronic Widespread Pain? PLoS One (2016) 0.78

Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST). Neurosci Lett (2015) 0.77

The role for epigenetic modifications in pain and analgesia response. Nurs Res Pract (2013) 0.76

DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nat Commun (2017) 0.76

Neuron-restrictive silencer factor-mediated downregulation of μ-opioid receptor contributes to the reduced morphine analgesia in bone cancer pain. Pain (2017) 0.75

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. Mol Pain (2017) 0.75

Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons. Pain (2017) 0.75

CDRI-08 Attenuates REST/NRSF-Mediated Expression of NMDAR1 Gene in PBDE-209-Exposed Mice Brain. Evid Based Complement Alternat Med (2015) 0.75

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. Pharmgenomics Pers Med (2017) 0.75

Articles by these authors

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci (2007) 3.81

Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging. J Magn Reson Imaging (2002) 3.35

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med (2004) 2.71

A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods. J Altern Complement Med (2002) 2.70

A new concept of endoscopic lung cancer resection: Single-direction thoracoscopic lobectomy. Surg Oncol (2009) 2.31

TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20

Volume of mammographic density and risk of breast cancer. Cancer Epidemiol Biomarkers Prev (2011) 2.18

Hepatocellular carcinoma: stiffness value and ratio to discriminate malignant from benign focal liver lesions. Radiology (2015) 2.03

Dental changes evaluated with a 3D computer-assisted model analysis after long-term tongue retaining device wear in OSA patients. Sleep Breath (2008) 2.02

On the statistical errors of RADAR location sensor networks with built-in Wi-Fi Gaussian linear fingerprints. Sensors (Basel) (2012) 1.97

Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum (2004) 1.94

Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity. Blood (2011) 1.83

RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res (2004) 1.83

Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood (2014) 1.81

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem (2004) 1.80

Breastfeeding of newborns by mothers carrying hepatitis B virus: a meta-analysis and systematic review. Arch Pediatr Adolesc Med (2011) 1.76

Experimental demonstration of 4D imaging in two-phase flows based on computed tomography at 5  kHz. Appl Opt (2014) 1.69

Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem (2002) 1.60

Simultaneous detection and serotype identification of Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization. J Med Microbiol (2005) 1.59

Cardiopulmonary arrest following cervical epidural injection. Pain Physician (2012) 1.56

Diagnostic value of minimum apparent diffusion coefficient values in prediction of neuroepithelial tumor grading. J Magn Reson Imaging (2010) 1.54

Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging. Radiology (2006) 1.49

Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. Eur J Med Chem (2007) 1.48

Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46

Comparison of three-dimensional volume-targeted thin-slab FIESTA magnetic resonance angiography and 64-multidetector computed tomographic angiography for the identification of proximal coronary stenosis. Int J Cardiol (2012) 1.39

Alpha-glucosidase inhibition of natural curcuminoids and curcumin analogs. Eur J Med Chem (2006) 1.32

The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer. BMC Cancer (2010) 1.30

Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain. J Pharmacol Exp Ther (2003) 1.30

Complete nucleotide sequence and organization of the naphthalene catabolic plasmid pND6-1 from Pseudomonas sp. strain ND6. Gene (2004) 1.28

Applications of loop-mediated isothermal DNA amplification. Appl Biochem Biotechnol (2010) 1.27

Lamivudine in late pregnancy to interrupt in utero transmission of hepatitis B virus: a systematic review and meta-analysis. Obstet Gynecol (2010) 1.25

A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol (2004) 1.24

Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin. J Pharmacol Exp Ther (2006) 1.24

Oral health, general health, and quality of life in older people. Spec Care Dentist (2008) 1.24

Mammographic density and risk of breast cancer by age and tumor characteristics. Breast Cancer Res (2013) 1.23

Nephrogenic systemic fibrosis: review of 408 biopsy-confirmed cases. Indian J Dermatol (2011) 1.21

Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungus Aspergillus sp. 085242. Org Lett (2013) 1.19

Treatment of Kawasaki disease: analysis of 27 US pediatric hospitals from 2001 to 2006. Pediatrics (2009) 1.17

1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem (2008) 1.17

Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. Eur J Med Chem (2009) 1.17

Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. J Biol Chem (2009) 1.17

Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A (2002) 1.14

Urban poverty: an urgent public health issue. J Urban Health (2007) 1.14

TRPM1: a vertebrate TRP channel responsible for retinal ON bipolar function. Cell Calcium (2010) 1.13

Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Mol Pain (2008) 1.13

Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. J Neurosci (2003) 1.12

Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients. J Exp Clin Cancer Res (2010) 1.12

Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J (2002) 1.12

Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain. J Pharmacol Exp Ther (2004) 1.11

A novel method for troubleshooting vascular injury during anatomic thoracoscopic pulmonary resection without conversion to thoracotomy. Surg Endosc (2012) 1.11

Interleukin-17 and prostaglandin E2 are involved in formation of an M2 macrophage-dominant microenvironment in lung cancer. J Thorac Oncol (2012) 1.10

Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors. Chem Pharm Bull (Tokyo) (2009) 1.10

Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children. J Med Microbiol (2012) 1.09

Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China. PLoS One (2012) 1.09

In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. Antimicrob Agents Chemother (2007) 1.09

Hepatitis B immunoglobulin injection in pregnancy to interrupt hepatitis B virus mother-to-child transmission-a meta-analysis. Int J Infect Dis (2010) 1.08

Value of video-assisted thoracic surgery core needle biopsy in the selection of surgical approaches for indeterminate pulmonary nodules. Ann Thorac Surg (2013) 1.08

Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia. J Neurosci (2005) 1.07

Impaired response inhibition function in abstinent heroin dependents: an fMRI study. Neurosci Lett (2008) 1.06

Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Gastroenterology (2002) 1.06

Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells. Cancer Res (2003) 1.05

Curcumin analogs as potent aldose reductase inhibitors. Arch Pharm (Weinheim) (2006) 1.05

A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem (2008) 1.04

Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem (2012) 1.04

Grey matter volume changes over the whole brain in amyotrophic lateral sclerosis: A voxel-wise meta-analysis of voxel based morphometry studies. Amyotroph Lateral Scler (2010) 1.03

A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea. Sleep Med (2011) 1.02

Kalman/Map filtering-aided fast normalized cross correlation-based Wi-Fi fingerprinting location sensing. Sensors (Basel) (2013) 1.01

Olfactory imprinting of amino acids in lacustrine sockeye salmon. PLoS One (2010) 1.00

The origin of fluorescence from graphene oxide. Sci Rep (2012) 1.00

Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine. Mol Pain (2010) 1.00

Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL. Eur J Radiol (2011) 1.00

Language barriers, location of care, and delays in follow-up of abnormal mammograms. Med Care (2012) 0.99

Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice. J Pharmacol Exp Ther (2003) 0.99

Video-assisted thoracic surgery for pulmonary sequestration compared with posterolateral thoracotomy. J Thorac Cardiovasc Surg (2013) 0.98

Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. J Med Chem (2005) 0.97

Intra- and interscanner reliability and reproducibility of 3D whole-brain pseudo-continuous arterial spin-labeling MR perfusion at 3T. J Magn Reson Imaging (2013) 0.97

Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test. Mol Pain (2006) 0.97

Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis. J Neurol (2004) 0.96

Noncompetitive detection of low molecular weight peptides by open sandwich immunoassay. Anal Chem (2007) 0.96

Emerging functions for tuberoinfundibular peptide of 39 residues. Trends Endocrinol Metab (2003) 0.96

"Quenchbodies": quench-based antibody probes that show antigen-dependent fluorescence. J Am Chem Soc (2011) 0.96

Corticospinal tract degeneration in amyotrophic lateral sclerosis: a diffusion tensor imaging and fibre tractography study. Ann Acad Med Singapore (2008) 0.96

Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism. Brain Res (2002) 0.96

Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury. Mol Pain (2008) 0.95

A reinforcement sensor embedded vertical handoff controller for vehicular heterogeneous wireless networks. Sensors (Basel) (2013) 0.95

Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain. J Pharmacol Exp Ther (2010) 0.95

Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice. J Pharmacol Exp Ther (2003) 0.95

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. Mol Pain (2009) 0.95

Minimization of MR contrast weightings for the comprehensive evaluation of carotid atherosclerotic disease. Invest Radiol (2010) 0.95

Dynamic neural responses to cue-reactivity paradigms in heroin-dependent users: an fMRI study. Hum Brain Mapp (2009) 0.94

Intracranial hemangiopericytoma: MR imaging findings and diagnostic usefulness of minimum ADC values. J Magn Reson Imaging (2013) 0.94

Cyclic RGD peptide-labeled upconversion nanophosphors for tumor cell-targeted imaging. Biochem Biophys Res Commun (2009) 0.94

Chaperone-assisted folding of a single-chain antibody in a reconstituted translation system. Biochem Biophys Res Commun (2004) 0.94

Nasal pressure recordings to detect obstructive sleep apnea. Sleep Breath (2006) 0.93

MR findings of Rosai-Dorfman disease in sellar and suprasellar region. Eur J Radiol (2011) 0.93

LPA-mediated demyelination in ex vivo culture of dorsal root. Neurochem Int (2006) 0.92

Phosphorus flows and use efficiencies in production and consumption of wheat, rice, and maize in China. Chemosphere (2011) 0.92

Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system. Dev Dyn (2005) 0.92