PubRank

Joseph T Barbieri

Author PubWeight™ 73.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Bacterial cytotoxins: targeting eukaryotic switches. Nat Rev Microbiol 2005 1.98
2 An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A 2007 1.85
3 Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors. J Comb Chem 2006 1.79
4 Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 regulator of kinase (Crk) proteins. J Biol Chem 2003 1.60
5 Unique substrate recognition by botulinum neurotoxins serotypes A and E. J Biol Chem 2006 1.54
6 The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability. Protein Expr Purif 2004 1.45
7 Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F. Biochemistry 2009 1.41
8 Subunit vaccine against the seven serotypes of botulism. Infect Immun 2007 1.39
9 Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. Annu Rev Microbiol 2008 1.35
10 In vivo rho GTPase-activating protein activity of Pseudomonas aeruginosa cytotoxin ExoS. Infect Immun 2002 1.35
11 Mechanism of substrate recognition by botulinum neurotoxin serotype A. J Biol Chem 2007 1.30
12 Intracellular localization modulates targeting of ExoS, a type III cytotoxin, to eukaryotic signalling proteins. Mol Microbiol 2002 1.17
13 Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. J Biol Chem 2002 1.16
14 Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors. J Am Chem Soc 2010 1.14
15 Intracellular membrane localization of pseudomonas ExoS and Yersinia YopE in mammalian cells. J Biol Chem 2003 1.14
16 Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes. Biochemistry 2007 1.14
17 Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl Acad Sci U S A 2011 1.12
18 Gangliosides as high affinity receptors for tetanus neurotoxin. J Biol Chem 2009 1.12
19 Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin. J Biol Chem 2008 1.11
20 Multiple pocket recognition of SNAP25 by botulinum neurotoxin serotype E. J Biol Chem 2007 1.10
21 Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E. Infect Immun 2005 1.10
22 Recombinant holotoxoid vaccine against botulism. Infect Immun 2007 1.09
23 Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. FEBS Lett 2010 1.07
24 Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS. J Biol Chem 2004 1.05
25 How bacterial ADP-ribosylating toxins recognize substrates. Nat Struct Mol Biol 2004 1.04
26 Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. Biochemistry 2006 1.04
27 Uncoupling Crk signal transduction by Pseudomonas exoenzyme T. J Biol Chem 2005 1.03
28 The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells. Infect Immun 2010 1.03
29 ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA. Biochemistry 2002 1.02
30 Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA . Biochemistry 2010 1.01
31 Intracellular localization of type III-delivered Pseudomonas ExoS with endosome vesicles. J Biol Chem 2007 1.01
32 Catalytic properties of botulinum neurotoxin subtypes A3 and A4. Biochemistry 2009 0.99
33 Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Org Lett 2010 0.99
34 A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells. Infect Immun 2005 0.99
35 Children with cystic fibrosis produce an immune response against exoenzyme S, a type III cytotoxin of Pseudomonas aeruginosa. J Infect Dis 2002 0.98
36 Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system. Infect Immun 2012 0.97
37 Modulation of host cell endocytosis by the type III cytotoxin, Pseudomonas ExoS. Traffic 2008 0.96
38 Molecular basis for tetanus toxin coreceptor interactions. Biochemistry 2008 0.96
39 Vaccines against botulism. Curr Opin Microbiol 2012 0.96
40 ExoS Rho GTPase-activating protein activity stimulates reorganization of the actin cytoskeleton through Rho GTPase guanine nucleotide disassociation inhibitor. J Biol Chem 2004 0.95
41 Engineering botulinum neurotoxin to extend therapeutic intervention. Proc Natl Acad Sci U S A 2009 0.95
42 Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. Nat Struct Mol Biol 2007 0.93
43 Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25. J Biol Chem 2011 0.91
44 Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase. Bioorg Med Chem Lett 2009 0.90
45 Structural analysis of botulinum neurotoxin type G receptor binding . Biochemistry 2010 0.90
46 Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS. Cell Microbiol 2007 0.89
47 Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons. J Biol Chem 2011 0.89
48 Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease. ACS Med Chem Lett 2010 0.89
49 Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation. Cell Microbiol 2006 0.89
50 Insights into the different catalytic activities of Clostridium neurotoxins. Biochemistry 2012 0.89
51 Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry. J Biol Chem 2012 0.88
52 Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. Infect Immun 2002 0.88
53 Toxins from bacteria. EXS 2010 0.87
54 Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors. Bioorg Med Chem Lett 2009 0.85
55 Association of botulinum neurotoxins with synaptic vesicle protein complexes. Toxicon 2009 0.85
56 Intracellular trafficking of Pseudomonas ExoS, a type III cytotoxin. Traffic 2007 0.85
57 The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft. ACS Med Chem Lett 2012 0.84
58 Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence. Microb Pathog 2011 0.84
59 The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. J Biol Chem 2014 0.83
60 Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells. Infect Immun 2013 0.83
61 General aspects and recent advances on bacterial protein toxins. Cold Spring Harb Perspect Med 2013 0.83
62 Subunit vaccine efficacy against Botulinum neurotoxin subtypes. Vaccine 2011 0.81
63 Enhancing the protective immune response against botulism. Infect Immun 2013 0.81
64 Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S. Biochemistry 2003 0.81
65 Proteomic identification of OprL as a seromarker for initial diagnosis of Pseudomonas aeruginosa infection of patients with cystic fibrosis. J Clin Microbiol 2009 0.80
66 Host cell cytotoxicity and cytoskeleton disruption by CerADPr, an ADP-ribosyltransferase of Bacillus cereus G9241. Biochemistry 2013 0.79
67 Pseudomonas aeruginosa utilizes the type III secreted toxin ExoS to avoid acidified compartments within epithelial cells. PLoS One 2013 0.79
68 Unique ganglioside binding by botulinum neurotoxins C and D-SA. FEBS J 2011 0.78
69 Exoenzyme S ADP-ribosylates Rab5 effector sites to uncouple intracellular trafficking. Infect Immun 2013 0.78
70 Expression and purification of two recombinant forms of the type-III cytotoxin, Pseudomonas aeruginosa ExoS. Protein Expr Purif 2002 0.78
71 Bacillus cereus Certhrax ADP-ribosylates vinculin to disrupt focal adhesion complexes and cell adhesion. J Biol Chem 2014 0.76
72 Multiple domains of tetanus toxin direct entry into primary neurons. Traffic 2014 0.75