|
1
|
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.
|
Mol Ther
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2006
|
2.41
|
|
2
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Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents.
|
J Neurosurg
|
2005
|
2.07
|
|
3
|
A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys.
|
Mol Ther
|
2006
|
1.77
|
|
4
|
Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging.
|
Brain Res Brain Res Protoc
|
2005
|
1.74
|
|
5
|
Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain.
|
Hum Gene Ther
|
2006
|
1.72
|
|
6
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Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.
|
Proc Natl Acad Sci U S A
|
2009
|
1.70
|
|
7
|
Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response.
|
Hum Gene Ther
|
2009
|
1.55
|
|
8
|
Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.
|
Neuroimage
|
2008
|
1.53
|
|
9
|
Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.
|
Hum Gene Ther
|
2009
|
1.46
|
|
10
|
Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain.
|
Mol Ther
|
2008
|
1.40
|
|
11
|
Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery.
|
J Neurosurg
|
2008
|
1.40
|
|
12
|
Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.
|
Hum Gene Ther
|
2009
|
1.36
|
|
13
|
Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen.
|
Exp Neurol
|
2005
|
1.32
|
|
14
|
Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.
|
Mol Ther
|
2010
|
1.31
|
|
15
|
Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates.
|
Neuroimage
|
2009
|
1.24
|
|
16
|
Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys.
|
Exp Neurol
|
2005
|
1.17
|
|
17
|
Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.
|
J Neurosci
|
2010
|
1.14
|
|
18
|
Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors.
|
Mol Ther
|
2010
|
1.09
|
|
19
|
Image-guided convection-enhanced delivery of GDNF protein into monkey putamen.
|
Neuroimage
|
2010
|
1.02
|
|
20
|
Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum.
|
Hum Gene Ther
|
2012
|
1.02
|
|
21
|
Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain.
|
Hum Gene Ther
|
2004
|
1.00
|
|
22
|
Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeys.
|
Neuroreport
|
2006
|
1.00
|
|
23
|
Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics.
|
J Neurosurg
|
2010
|
0.99
|
|
24
|
T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery.
|
Neurosurgery
|
2011
|
0.93
|
|
25
|
Design of an in-dwelling cannula for convection-enhanced delivery.
|
J Neurosci Methods
|
2010
|
0.93
|
|
26
|
Comparison of two methods for the analysis of [18F]6-fluoro-L-m-tyrosine PET data.
|
Neuroimage
|
2004
|
0.91
|
|
27
|
Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion.
|
Exp Neurol
|
2011
|
0.89
|
|
28
|
Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.
|
Hum Gene Ther
|
2012
|
0.89
|
|
29
|
Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain.
|
Magn Reson Med
|
2013
|
0.88
|
|
30
|
Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A.
|
Mol Ther
|
2012
|
0.84
|
|
31
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Invasive phenotype observed in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant sublines of 9L rat glioma cells: a tumor model mimicking a recurrent malignant glioma.
|
J Neurosurg
|
2004
|
0.83
|
|
32
|
Anatomic compression caused by high-volume convection-enhanced delivery to the brain.
|
Neurosurgery
|
2009
|
0.82
|
|
33
|
Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 Tesla MRI.
|
J Magn Reson Imaging
|
2012
|
0.77
|
|
34
|
The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys.
|
Exp Neurol
|
2002
|
0.76
|