Published in J Innate Immun on March 16, 2010
Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model. Plast Reconstr Surg (2015) 1.41
Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol (2012) 1.15
Broad action of Hsp90 as a host chaperone required for viral replication. Biochim Biophys Acta (2011) 1.13
Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock. J Biomed Biotechnol (2011) 1.09
Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm repair. Cell Stress Chaperones (2010) 1.07
Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clin Dev Immunol (2013) 1.07
Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. J Clin Biochem Nutr (2012) 1.04
Plasmodium falciparum-infected erythrocytes induce granzyme B by NK cells through expression of host-Hsp70. PLoS One (2012) 1.02
Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury. Crit Care (2011) 0.99
Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J (2011) 0.98
Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential. Transl Stroke Res (2013) 0.95
Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Toxicol Appl Pharmacol (2011) 0.93
Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins. ACS Chem Biol (2011) 0.93
Heat shock protein as molecular targets for breast cancer therapeutics. J Breast Cancer (2011) 0.93
Combination radiofrequency (RF) ablation and IV liposomal heat shock protein suppression: reduced tumor growth and increased animal endpoint survival in a small animal tumor model. J Control Release (2011) 0.93
Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Mol Med (2012) 0.93
Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications. Front Immunol (2015) 0.92
Cellular mechanisms regulating sperm-zona pellucida interaction. Asian J Androl (2010) 0.92
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation. PLoS One (2011) 0.92
Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice. Hepatology (2012) 0.91
DAMPs activating innate and adaptive immune responses in COPD. Mucosal Immunol (2013) 0.89
Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia (2014) 0.88
The immunosuppressive activity of heat shock protein 70. Autoimmune Dis (2012) 0.87
Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes. Transl Res (2015) 0.86
Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response to Anaplasma spp. Infection and Heat Shock. Int J Proteomics (2010) 0.85
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis (2013) 0.85
Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins. PLoS One (2014) 0.84
Nosema Tolerant Honeybees (Apis mellifera) Escape Parasitic Manipulation of Apoptosis. PLoS One (2015) 0.84
Heat shock proteins as danger signals for cancer detection. Front Oncol (2011) 0.83
Lysosomal rerouting of Hsp70 trafficking as a potential immune activating tool for targeting melanoma. Curr Pharm Des (2013) 0.83
Heat shock proteins in chronic kidney disease. Pediatr Nephrol (2010) 0.83
Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland. Biol Open (2012) 0.82
Development of salinity tolerance in rice by constitutive-overexpression of genes involved in the regulation of programmed cell death. Front Plant Sci (2015) 0.82
Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia. Free Radic Biol Med (2011) 0.82
Heat shock proteins 60 and 70 specific proinflammatory and cytotoxic response of CD4+CD28null cells in chronic kidney disease. Mediators Inflamm (2013) 0.82
Two HSPs gene from juvenile Amur sturgeon (Acipenser schrenckii): cloning, characterization and expression pattern to crowding and hypoxia stress. Fish Physiol Biochem (2014) 0.82
Hsp27 as a marker of cell damage in children on chronic dialysis. Cell Stress Chaperones (2012) 0.80
Antitumor activity of human hydatid cyst fluid in a murine model of colon cancer. ScientificWorldJournal (2013) 0.80
Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Oncotarget (2015) 0.80
Separation and identification of HSP-associated protein complexes from pancreatic cancer cell lines using 2D CN/SDS-PAGE coupled with mass spectrometry. J Biomed Biotechnol (2011) 0.80
Mini-chaperones: potential immuno-stimulators in vaccine design. Hum Vaccin Immunother (2012) 0.79
Human monoclonal antibody-based therapy in the treatment of invasive candidiasis. Clin Dev Immunol (2013) 0.79
Protective effect of melatonin on acute pancreatitis. Int J Inflam (2012) 0.79
HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms. Mediators Inflamm (2015) 0.78
Circulating anti-Hsp70 levels in nascent metabolic syndrome: the Casale Monferrato Study. Cell Stress Chaperones (2012) 0.78
Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. PLoS One (2014) 0.78
Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest. Mol Cells (2012) 0.77
Cryo-thermal therapy elicits potent anti-tumor immunity by inducing extracellular Hsp70-dependent MDSC differentiation. Sci Rep (2016) 0.77
Extracellular HSP110 skews macrophage polarization in colorectal cancer. Oncoimmunology (2016) 0.77
The role of TGF-β signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach. BMC Syst Biol (2014) 0.77
Characterization of differential Toll-like receptor responses below the optical diffraction limit. Small (2012) 0.77
Vorinostat in combination with bortezomib in patients with advanced malignancies directly alters transcription of target genes. Cancer Chemother Pharmacol (2013) 0.77
Heat shock proteins and regulatory T cells. Autoimmune Dis (2013) 0.77
Evidence of multimeric forms of HSP70 with phosphorylation on serine and tyrosine residues--implications for roles of HSP70 in detection of GI cancers. Asian Pac J Cancer Prev (2013) 0.76
Contribution of chaperones to STAT pathway signaling. JAKSTAT (2014) 0.76
Cardiac and hepatic role of r-AtHSP70: basal effects and protection against ischemic and sepsis conditions. J Cell Mol Med (2015) 0.76
Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin. World J Gastroenterol (2014) 0.75
Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation. PLoS One (2014) 0.75
The role of heat shock proteins in kidney disease. J Transl Int Med (2016) 0.75
Sexual dimorphism in Grp78 and Hsp90A heat shock protein expression in the estuarine copepod Eurytemora affinis. Cell Stress Chaperones (2013) 0.75
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer. Cell Stress Chaperones (2016) 0.75
The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks. Aging Dis (2017) 0.75
Expression times for hsp27 and hsp70 as an indicator of thermal stress during death due to fire. Int J Legal Med (2017) 0.75
Expression of Hsp27 and Hsp70 and vacuolization in the pituitary glands in cases of fatal hypothermia. Forensic Sci Med Pathol (2017) 0.75
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54
Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur J Immunol (2004) 5.02
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32
The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res (2010) 3.53
A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest (2010) 2.89
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med (2012) 2.71
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med (2011) 2.04
HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Mol Cell Biol (2003) 1.96
Chemotherapy and radiotherapy: cryptic anticancer vaccines. Semin Immunol (2010) 1.94
Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunol Immunother (2011) 1.93
Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth. J Invest Dermatol (2012) 1.90
Apoptosis regulation in tetraploid cancer cells. EMBO J (2006) 1.89
Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood (2002) 1.84
Targeting heat shock proteins in cancer. Cancer Lett (2010) 1.83
Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. Cancer Res (2010) 1.82
Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res (2008) 1.82
DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol (2002) 1.81
In situ immune response after neoadjuvant chemotherapy for breast cancer predicts survival. J Pathol (2011) 1.69
Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies. Cancer Res (2008) 1.69
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene (2004) 1.68
Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res (2009) 1.64
Cardiac glycosides exert anticancer effects by inducing immunogenic cell death. Sci Transl Med (2012) 1.63
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature (2006) 1.59
Ecto-calreticulin in immunogenic chemotherapy. Immunol Rev (2007) 1.55
Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene (2003) 1.52
Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines. J Immunol (2006) 1.52
Inhibition of HSP70: a challenging anti-cancer strategy. Cancer Lett (2012) 1.47
Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun (2003) 1.42
Vital functions for lethal caspases. Oncogene (2005) 1.40
Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy. Cell Biol Int (2008) 1.38
Leveraging the immune system during chemotherapy: moving calreticulin to the cell surface converts apoptotic death from "silent" to immunogenic. Cancer Res (2007) 1.37
TGF-beta1 induces progressive pleural scarring and subpleural fibrosis. J Immunol (2007) 1.36
Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy. Cancer Res (2011) 1.32
Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy. Breast Cancer Res Treat (2010) 1.31
Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model. Cancer Immunol Immunother (2009) 1.30
Regulation of cytoplasmic stress granules by apoptosis-inducing factor. J Cell Sci (2004) 1.29
Hsp70: anti-apoptotic and tumorigenic protein. Methods Mol Biol (2011) 1.29
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins. Curr Med Chem (2007) 1.26
Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27. Prion (2007) 1.26
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. Cancer Res (2006) 1.24
Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis. Nat Med (2011) 1.23
Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab? Clin Cancer Res (2008) 1.21
Cancer chemotherapy: not only a direct cytotoxic effect, but also an adjuvant for antitumor immunity. Cancer Immunol Immunother (2008) 1.21
HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells. FASEB J (2006) 1.21
Small heat shock proteins HSP27 and alphaB-crystallin: cytoprotective and oncogenic functions. Antioxid Redox Signal (2005) 1.20
Visceral fat area as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with antiangiogenic agents. Oncologist (2011) 1.20
Heat shock proteins: cell protection through protein triage. ScientificWorldJournal (2010) 1.19
Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Res (2012) 1.16
Desirable cell death during anticancer chemotherapy. Ann N Y Acad Sci (2010) 1.16
[Immunological aspects of anticancer chemotherapy]. Bull Acad Natl Med (2008) 1.08
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation. FASEB J (2013) 1.06
Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27. J Biol Chem (2010) 1.06
HSP27 controls GATA-1 protein level during erythroid cell differentiation. Blood (2010) 1.06
Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference. J Mol Med (Berl) (2007) 1.06
Transport, stability, and biological activity of resveratrol. Ann N Y Acad Sci (2011) 1.04
STAT3 activation: A key factor in tumor immunoescape. JAKSTAT (2013) 1.04
Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells. Cancer Genomics Proteomics (2007) 1.03
Cell-death-associated molecular patterns as determinants of cancer immunogenicity. Antioxid Redox Signal (2013) 1.02
Controversies on the role of Th17 in cancer: a TGF-β-dependent immunosuppressive activity? Trends Mol Med (2012) 1.01
Harnessing dendritic cells in cancer. Semin Immunol (2011) 1.01
CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer. J Clin Invest (2008) 1.01
Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells. PLoS One (2013) 0.99
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes. Blood (2011) 0.98
Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells. J Biol Chem (2010) 0.97
SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. Cancer Res (2013) 0.97
Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells. Haematologica (2011) 0.96
Tumor destruction using electrochemotherapy followed by CpG oligodeoxynucleotide injection induces distant tumor responses. Cancer Immunol Immunother (2008) 0.96
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res (2003) 0.96
Heat shock proteins in hematopoietic malignancies. Exp Cell Res (2012) 0.95
Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. J Immunol (2008) 0.95
Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Proc Natl Acad Sci U S A (2011) 0.95
Relation between bevacizumab dose intensity and high-grade glioma survival: a retrospective study in two large cohorts. J Neurooncol (2011) 0.95
HSPBs: small proteins with big implications in human disease. Int J Biochem Cell Biol (2012) 0.94
SNP array analysis reveals novel genomic abnormalities including copy neutral loss of heterozygosity in anaplastic oligodendrogliomas. PLoS One (2012) 0.94
Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3. FASEB J (2013) 0.94
TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT. PLoS One (2011) 0.92
Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD. Blood (2005) 0.92
Screening of anticancer drugs for chemoembolization of hepatocellular carcinoma. Anticancer Drugs (2011) 0.91
Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists. Mol Hum Reprod (2007) 0.89
Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer. Mol Ther (2012) 0.88
An atypical caspase-independent death pathway for an immunogenic cancer cell line. Oncogene (2002) 0.88
Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio. Cell Cycle (2012) 0.88
Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy. Gastroenterology (2014) 0.88
Influcence of localization of primary tumor on effectiveness of 5-fluorouracil/leucovorin combined with irinotecan and oxaliplatin (FOLFIRINOX) in patients with metastatic pancreatic adenocarcinoma: a retrospective study. Anticancer Res (2012) 0.88