Thiamine biosynthesis can be used to dissect metabolic integration.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 2906612)

Published in Trends Microbiol on April 08, 2010

Authors

Mark J Koenigsknecht1, Diana M Downs

Author Affiliations

1: Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.

Articles citing this

An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis. MBio (2016) 1.43

Microspatial gene expression patterns in the Amazon River Plume. Proc Natl Acad Sci U S A (2014) 1.10

The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola. J Bacteriol (2011) 0.95

Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate. ACS Chem Biol (2012) 0.88

Plasticity in the purine-thiamine metabolic network of Salmonella. Genetics (2010) 0.84

Amino-4-imidazolecarboxamide ribotide directly inhibits coenzyme A biosynthesis in Salmonella enterica. J Bacteriol (2013) 0.80

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. PLoS One (2012) 0.80

Evidence that TP_0144 of Treponema pallidum is a thiamine-binding protein. J Bacteriol (2015) 0.78

The Response to 2-Aminoacrylate Differs in E. coli and S. enterica, Despite Shared Metabolic Components. J Bacteriol (2017) 0.77

Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica. J Bacteriol (2015) 0.75

The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica. J Bacteriol (2015) 0.75

Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica. J Bacteriol (2015) 0.75

Time-Course Analysis of Gene Expression During the Saccharomyces cerevisiae Hypoxic Response. G3 (Bethesda) (2016) 0.75

Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron. mSystems (2017) 0.75

Articles cited by this

Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem (1956) 93.84

Reconstruction of biochemical networks in microorganisms. Nat Rev Microbiol (2008) 5.36

The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli. Nat Biotechnol (2008) 5.26

Metabolic networks in motion: 13C-based flux analysis. Mol Syst Biol (2006) 4.24

Global phenotypic characterization of bacteria. FEMS Microbiol Rev (2008) 2.97

Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol (2005) 2.95

OptStrain: a computational framework for redesign of microbial production systems. Genome Res (2004) 2.80

The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol. Nat Chem Biol (2007) 2.39

The structural and biochemical foundations of thiamin biosynthesis. Annu Rev Biochem (2009) 2.32

Essential genes on metabolic maps. Curr Opin Biotechnol (2006) 2.18

Identification of a new class of nitrogen fixation genes in Rhodobacter capsulatus: a putative membrane complex involved in electron transport to nitrogenase. Mol Gen Genet (1993) 2.05

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96

An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems. Metab Eng (2005) 1.90

Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions. Nat Prod Rep (2003) 1.87

apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium. J Bacteriol (1994) 1.84

Systems biology: Functional analysis of natural microbial consortia using community proteomics. Nat Rev Microbiol (2009) 1.81

A novel eukaryotic factor for cytosolic Fe-S cluster assembly. EMBO J (2003) 1.80

Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium. Genetics (1996) 1.65

Discovery of a natural thiamine adenine nucleotide. Nat Chem Biol (2007) 1.64

The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Proc Natl Acad Sci U S A (2005) 1.64

Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins. J Bacteriol (1998) 1.64

A reducing system of the superoxide sensor SoxR in Escherichia coli. EMBO J (2003) 1.53

Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium. J Bacteriol (1996) 1.52

Metabolic defects caused by mutations in the isc gene cluster in Salmonella enterica serovar typhimurium: implications for thiamine synthesis. J Bacteriol (2000) 1.48

Changes in conserved region 3 of Escherichia coli sigma 70 mediate ppGpp-dependent functions in vivo. J Mol Biol (1995) 1.45

ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis. Biochemistry (2008) 1.41

Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family. Proc Natl Acad Sci U S A (1999) 1.39

Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium. J Bacteriol (1996) 1.36

Exploring the overproduction of amino acids using the bilevel optimization framework OptKnock. Biotechnol Bioeng (2003) 1.34

Synthesis of thiamine in Salmonella typhimurium independent of the purF function. J Bacteriol (1991) 1.33

A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli. Protein Sci (1999) 1.33

Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family. Biochemistry (2003) 1.30

The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium. J Bacteriol (1998) 1.28

Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium. J Bacteriol (2003) 1.28

New surveyor tools for charting microbial metabolic maps. Nat Rev Microbiol (2008) 1.28

Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. Org Biomol Chem (2004) 1.26

The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family. BMC Struct Biol (2007) 1.26

YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. J Bacteriol (2008) 1.19

Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica. Proc Natl Acad Sci U S A (2001) 1.18

Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium. J Bacteriol (2004) 1.14

Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium. J Bacteriol (1997) 1.13

PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase. J Bacteriol (2006) 1.12

The nonenzymatic preparation in solution of N-(5'-phosphoribosyl) anthranilic acid, an intermediate in tryptophan biosynthesis. J Biol Chem (1968) 1.11

The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. J Bacteriol (1998) 1.10

Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo. J Bacteriol (2006) 1.07

Lesions in gshA (Encoding gamma-L-glutamyl-L-cysteine synthetase) prevent aerobic synthesis of thiamine in Salmonella enterica serovar typhimurium LT2. J Bacteriol (2000) 1.05

Lack of YggX results in chronic oxidative stress and uncovers subtle defects in Fe-S cluster metabolism in Salmonella enterica. J Bacteriol (2004) 1.05

Metabolic footprinting in microbiology: methods and applications in functional genomics and biotechnology. Trends Biotechnol (2008) 1.01

Reduced flux through the purine biosynthetic pathway results in an increased requirement for coenzyme A in thiamine synthesis in Salmonella enterica serovar typhimurium. J Bacteriol (2000) 1.00

Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation. J Biol Chem (2004) 1.00

Bacterial ApbC can bind and effectively transfer iron-sulfur clusters. Biochemistry (2008) 1.00

Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Acta Crystallogr D Biol Crystallogr (2003) 0.98

Thiamine biosynthesis in Escherichia coli: in vitro reconstitution of the thiazole synthase activity. J Biol Chem (2004) 0.98

Reaction of AdoMet with ThiC generates a backbone free radical. Biochemistry (2009) 0.96

Defects in pyruvate kinase cause a conditional increase of thiamine synthesis in Salmonella typhimurium. Can J Microbiol (1999) 0.94

A periplasmic location is essential for the role of the ApbE lipoprotein in thiamine synthesis in Salmonella typhimurium. J Bacteriol (1999) 0.94

Mutations in the tryptophan operon allow PurF-independent thiamine synthesis by altering flux in vivo. J Bacteriol (2007) 0.94

Understanding microbial metabolism. Annu Rev Microbiol (2006) 0.94

Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB J (2000) 0.94

Lesions in the nuo operon, encoding NADH dehydrogenase complex I, prevent PurF-independent thiamine synthesis and reduce flux through the oxidative pentose phosphate pathway in Salmonella enterica serovar typhimurium. J Bacteriol (2000) 0.92

Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica. Microbiology (2009) 0.91

Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. J Biol Chem (2004) 0.91

Crystal structure of the YjgF/YER057c/UK114 family protein from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7. Proteins (2006) 0.90

Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU. J Bacteriol (2008) 0.90

Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain. J Biol Chem (2009) 0.87

Thiamine triphosphate activates an anion channel of large unit conductance in neuroblastoma cells. J Membr Biol (1993) 0.87

Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF. Int J Biol Macromol (2005) 0.84

An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source. J Bacteriol (2006) 0.79

A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica. J Bacteriol (2004) 0.79

Articles by these authors

ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis. Biochemistry (2008) 1.41

Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium. J Bacteriol (2003) 1.28

Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. J Biol Chem (2011) 1.21

YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. J Bacteriol (2008) 1.19

Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium. J Bacteriol (2004) 1.14

PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase. J Bacteriol (2006) 1.12

RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life. MBio (2013) 1.05

Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro. J Biol Chem (2010) 1.05

The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. J Biol Chem (2003) 1.03

A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica. Microbiology (2006) 1.02

Bacterial ApbC can bind and effectively transfer iron-sulfur clusters. Biochemistry (2008) 1.00

Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica. J Bacteriol (2002) 0.99

Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica. J Bacteriol (2003) 0.99

Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. Structure (2004) 0.97

The rhodanese domain of ThiI is both necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica. J Bacteriol (2011) 0.97

Reaction of AdoMet with ThiC generates a backbone free radical. Biochemistry (2009) 0.96

Archaeal ApbC/Nbp35 homologs function as iron-sulfur cluster carrier proteins. J Bacteriol (2008) 0.96

Cobalt targets multiple metabolic processes in Salmonella enterica. J Bacteriol (2007) 0.95

Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. J Biol Chem (2004) 0.94

Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol. J Biol Chem (2006) 0.93

Bacterial ApbC protein has two biochemical activities that are required for in vivo function. J Biol Chem (2008) 0.92

In the absence of RidA, endogenous 2-aminoacrylate inactivates alanine racemases by modifying the pyridoxal 5'-phosphate cofactor. J Bacteriol (2013) 0.92

The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains. J Bacteriol (2003) 0.92

Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica. Microbiology (2009) 0.91

Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. J Biol Chem (2004) 0.91

Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU. J Bacteriol (2008) 0.90

FAD binding by ApbE protein from Salmonella enterica: a new class of FAD-binding proteins. J Bacteriol (2010) 0.89

Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate. ACS Chem Biol (2012) 0.88

Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase. Mol Microbiol (2013) 0.88

Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica. Microbiology (2009) 0.86

Plasticity in the purine-thiamine metabolic network of Salmonella. Genetics (2010) 0.84

Suppressor analyses identify threonine as a modulator of ridA mutant phenotypes in Salmonella enterica. PLoS One (2012) 0.84

The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites. J Biol Chem (2013) 0.82

Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica. J Bacteriol (2012) 0.82

Glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine. J Biol Chem (2007) 0.82

Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking. Proteins (2006) 0.81

Analysis of yggX and gshA mutants provides insights into the labile iron pool in Salmonella enterica. J Bacteriol (2008) 0.80

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. PLoS One (2012) 0.80

Amino-4-imidazolecarboxamide ribotide directly inhibits coenzyme A biosynthesis in Salmonella enterica. J Bacteriol (2013) 0.80

An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source. J Bacteriol (2006) 0.79

A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica. J Bacteriol (2004) 0.79

Involvement of the Cra global regulatory protein in the expression of the iscRSUA operon, revealed during studies of tricarballylate catabolism in Salmonella enterica. J Bacteriol (2009) 0.76

MMBR to highlight microbial evolution, diversity, and ecology in 2009. Microbiol Mol Biol Rev (2009) 0.75

Decreased transport restores growth of a Salmonella enterica apbC mutant on tricarballylate. J Bacteriol (2011) 0.75