Published in Angew Chem Int Ed Engl on May 17, 2010
Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS Chem Biol (2012) 1.43
Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat Chem Biol (2014) 1.41
A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome. ACS Chem Biol (2012) 1.16
Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. J Am Chem Soc (2011) 1.09
Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations. Nat Commun (2012) 0.97
Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening. ACS Chem Biol (2012) 0.93
Small molecule chemical probes of microRNA function. Curr Opin Chem Biol (2014) 0.88
Features of modularly assembled compounds that impart bioactivity against an RNA target. ACS Chem Biol (2013) 0.88
Secondary structure of a conserved domain in the intron of influenza A NS1 mRNA. PLoS One (2013) 0.86
Methods to enable the design of bioactive small molecules targeting RNA. Org Biomol Chem (2014) 0.86
Small-molecule-mediated cleavage of RNA in living cells. Angew Chem Int Ed Engl (2012) 0.84
Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Chem Commun (Camb) (2014) 0.84
Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. ACS Chem Biol (2014) 0.82
Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs. ACS Chem Biol (2016) 0.81
Small molecules targeting microRNA for cancer therapy: Promises and obstacles. J Control Release (2015) 0.80
Structure based approaches for targeting non-coding RNAs with small molecules. Curr Opin Struct Biol (2015) 0.79
Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence. Acc Chem Res (2016) 0.79
Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray. Methods Mol Biol (2012) 0.76
The Emerging Role of RNA as a Therapeutic Target for Small Molecules. Cell Chem Biol (2016) 0.75
Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA. ACS Cent Sci (2017) 0.75
Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing. Bioorg Med Chem (2013) 0.75
Targeting RNA with small molecules. Chem Rev (2008) 3.66
Riboswitches as antibacterial drug targets. Nat Biotechnol (2006) 3.01
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. J Am Chem Soc (2009) 2.06
Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. J Am Chem Soc (2008) 1.84
A small molecule microarray platform to select RNA internal loop-ligand interactions. ACS Chem Biol (2007) 1.83
Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2. ACS Chem Biol (2009) 1.83
MicroRNAs as therapeutic targets in human diseases. Expert Opin Ther Targets (2007) 1.32
Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions. Nucleic Acids Res (2009) 1.00
Myotonic dystrophy: therapeutic strategies for the future. Neurotherapeutics (2008) 0.96
A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. RNA (2007) 0.87
Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proc Natl Acad Sci U S A (2004) 10.35
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. J Am Chem Soc (2009) 2.06
Recent advances in developing small molecules targeting RNA. ACS Chem Biol (2012) 1.97
Hybridization-based unquenching of DNA hairpins on au surfaces: prototypical "molecular beacon" biosensors. J Am Chem Soc (2003) 1.88
A small molecule microarray platform to select RNA internal loop-ligand interactions. ACS Chem Biol (2007) 1.83
Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2. ACS Chem Biol (2009) 1.83
A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA. Nat Methods (2013) 1.62
Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Rep (2013) 1.56
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science (2014) 1.54
Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. J Am Chem Soc (2009) 1.54
Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. J Am Chem Soc (2012) 1.44
Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS Chem Biol (2012) 1.43
Tools for glycomics: mapping interactions of carbohydrates in biological systems. Chembiochem (2004) 1.32
Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing. Proc Natl Acad Sci U S A (2002) 1.21
A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Mol Microbiol (2006) 1.16
Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. J Am Chem Soc (2011) 1.09
Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. Biochemistry (2008) 1.06
Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts. ACS Chem Biol (2012) 1.05
Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. ACS Chem Biol (2012) 1.01
Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nat Commun (2013) 1.01
Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations. Biochemistry (2011) 1.00
Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions. Nucleic Acids Res (2009) 1.00
Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions. Angew Chem Int Ed Engl (2013) 0.98
Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations. Nat Commun (2012) 0.97
NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1. Biochemistry (2011) 0.95
Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides. Biochemistry (2010) 0.95
Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron. ACS Chem Biol (2009) 0.94
Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening. ACS Chem Biol (2012) 0.93
Features of modularly assembled compounds that impart bioactivity against an RNA target. ACS Chem Biol (2013) 0.88
Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches. Biochemistry (2011) 0.88
A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. RNA (2007) 0.87
Using modularly assembled ligands to bind RNA internal loops separated by different distances. Chembiochem (2011) 0.87
A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor. Angew Chem Int Ed Engl (2014) 0.87
A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem (2011) 0.85
Miniaturization of microwave-assisted carbohydrate functionalization to create oligosaccharide microarrays. Chembiochem (2006) 0.84
Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Chem Commun (Camb) (2014) 0.84
Small-molecule-mediated cleavage of RNA in living cells. Angew Chem Int Ed Engl (2012) 0.84
A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations. J Am Chem Soc (2013) 0.84
Chemical microarrays to identify ligands that bind pathogenic cells. Chembiochem (2006) 0.83
Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray. Carbohydr Res (2008) 0.83
A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity. Chembiochem (2010) 0.83
Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. ACS Chem Biol (2014) 0.82
The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries. Bioorg Med Chem Lett (2010) 0.82
Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. J Biol Chem (2011) 0.80
Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10). Biochemistry (2015) 0.80
Influencing uptake and localization of aminoglycoside-functionalized peptoids. Mol Biosyst (2011) 0.80
Short-circuiting RNA splicing. Nat Chem Biol (2008) 0.79
Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA. Chembiochem (2014) 0.79
A microarray-based method to perform nucleic acid selections. Methods Mol Biol (2010) 0.79
T1 relaxation measurement with solvent suppression. Magn Reson Chem (2008) 0.75
Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing. Bioorg Med Chem (2013) 0.75
Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1. J Chem Theory Comput (2015) 0.75
Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS. Neuron (2014) 0.75
Corrigendum: A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor. Angew Chem Int Ed Engl (2016) 0.75