PubRank

Richard L Proia

Author PubWeight™ 129.17‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004 12.72
2 Lysosomal glycosphingolipid recognition by NKT cells. Science 2004 7.31
3 Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol 2004 3.65
4 Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 2005 3.59
5 The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol 2008 3.35
6 Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem 2004 3.22
7 The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity 2007 2.83
8 Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem 2004 2.81
9 Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature 2009 2.79
10 The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol 2009 2.73
11 The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem 2004 2.62
12 Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med 2005 2.57
13 Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A 2003 2.56
14 Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 2004 2.44
15 G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood 2003 2.27
16 Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev 2004 2.16
17 Combinatorial ganglioside biosynthesis. J Biol Chem 2002 2.06
18 Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol 2006 2.04
19 Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest 2007 1.89
20 Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J 2006 1.72
21 Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem 2007 1.66
22 IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem 2005 1.55
23 Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med 2006 1.51
24 Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res 2008 1.51
25 Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci 2007 1.49
26 Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Proc Natl Acad Sci U S A 2004 1.48
27 Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage. J Clin Invest 2002 1.45
28 S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med 2010 1.43
29 Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc Natl Acad Sci U S A 2005 1.43
30 Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J Biol Chem 2007 1.41
31 Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. Proc Natl Acad Sci U S A 2006 1.41
32 Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem 2010 1.40
33 The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol 2011 1.39
34 The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood 2005 1.38
35 Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest 2007 1.36
36 Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat 2004 1.35
37 Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling. Hum Mol Genet 2002 1.34
38 Lubricating cell signaling pathways with gangliosides. Curr Opin Struct Biol 2002 1.33
39 Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. Mol Genet Metab 2005 1.32
40 Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest 2010 1.31
41 Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem 2010 1.27
42 Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem 2005 1.24
43 Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest 2015 1.24
44 Kidney sulfatides in mouse models of inherited glycosphingolipid disorders: determination by nano-electrospray ionization tandem mass spectrometry. J Biol Chem 2002 1.23
45 Sphingosine-1-phosphate receptors and the development of the vascular system. Biochim Biophys Acta 2002 1.22
46 S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J 2007 1.20
47 A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med 2012 1.18
48 Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. Hum Mol Genet 2008 1.16
49 Novel class of glycosphingolipids involved in male fertility. J Biol Chem 2005 1.16
50 Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood 2008 1.15
51 Sphingosine-1-phosphate regulation of mammalian development. Biochim Biophys Acta 2008 1.14
52 Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons. J Biol Chem 2009 1.12
53 Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett 2006 1.07
54 Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One 2012 1.06
55 Shaping the landscape: metabolic regulation of S1P gradients. Biochim Biophys Acta 2012 1.06
56 Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest 2014 1.03
57 Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology 2005 0.98
58 Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol 2004 0.98
59 Physiological substrates for human lysosomal beta -hexosaminidase S. J Biol Chem 2001 0.97
60 Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction. J Neurochem 2005 0.95
61 Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem 2013 0.93
62 Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model. FASEB J 2011 0.92
63 Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia 2010 0.90
64 Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis. Genesis 2005 0.89
65 Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis. Biochim Biophys Acta 2002 0.88
66 B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs. J Immunol 2012 0.87
67 Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood 2008 0.87
68 Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. J Neurosci 2013 0.86
69 Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest 2014 0.86
70 Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem 2014 0.85
71 Global gene expression in a type 2 Gaucher disease brain. Mol Genet Metab 2004 0.84
72 Gangliosides help stabilize the brain. Nat Genet 2004 0.84
73 Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis. J Biol Chem 2013 0.83
74 Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function. Glycoconj J 2014 0.80
75 Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. J Leukoc Biol 2013 0.78
76 Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. J Immunol 2013 0.76
77 The GM1 and GM2 Gangliosidoses: Natural History and Progress toward Therapy. Pediatr Endocrinol Rev 2016 0.75
78 Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem 2016 0.75