PubRank

Douglas T Golenbock

Author PubWeight™ 239.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003 15.67
2 The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 2008 10.39
3 TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 2004 8.06
4 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 2003 5.97
5 CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 2009 5.87
6 Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 2003 4.56
7 HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006 4.53
8 IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A 2003 4.33
9 Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 2004 4.29
10 Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007 4.09
11 Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 2003 3.97
12 Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005 3.93
13 Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity 2011 3.74
14 NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2012 3.67
15 Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem 2002 3.58
16 Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc Natl Acad Sci U S A 2007 3.41
17 Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science 2008 3.38
18 Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci 2002 3.29
19 Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol 2005 2.85
20 Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011 2.81
21 A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem 2002 2.61
22 Inflammasomes: too big to miss. J Clin Invest 2009 2.51
23 The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem 2005 2.47
24 CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol 2013 2.38
25 Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A 2004 2.23
26 Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 2006 2.19
27 Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect 2004 2.19
28 Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 2004 2.16
29 The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A 2006 2.13
30 Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol 2002 2.11
31 The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics 2004 2.03
32 Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol 2002 2.00
33 TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA. Cell Host Microbe 2008 1.98
34 Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J Immunol 2007 1.95
35 Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002 1.92
36 Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J Biol Chem 2002 1.87
37 The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun 2005 1.86
38 MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur J Immunol 2005 1.85
39 Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J Biol Chem 2003 1.78
40 A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 2006 1.76
41 Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide. J Lipid Res 2009 1.70
42 Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci U S A 2009 1.70
43 Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol 2002 1.63
44 TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol 2009 1.61
45 Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. J Immunol 2006 1.61
46 MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol 2007 1.57
47 The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem 2003 1.55
48 Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect Immun 2004 1.49
49 Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 2004 1.49
50 YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol 2007 1.49
51 Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Infect Immun 2002 1.46
52 Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol 2007 1.44
53 MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol 2009 1.44
54 Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A 2011 1.44
55 Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling. J Immunol 2006 1.44
56 Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2. J Immunol 2005 1.42
57 Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis. J Immunol 2008 1.40
58 Innate immune recognition of Yersinia pseudotuberculosis type III secretion. PLoS Pathog 2009 1.38
59 Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe 2013 1.35
60 Role of lipoteichoic acid in the phagocyte response to group B streptococcus. J Immunol 2005 1.35
61 MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation. J Biol Chem 2009 1.35
62 MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem 2009 1.34
63 Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. J Immunol 2004 1.33
64 Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A 2006 1.33
65 Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol 2003 1.32
66 Beyond empiricism: informing vaccine development through innate immunity research. Cell 2012 1.31
67 MD-2. Immunobiology 2006 1.30
68 Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 2009 1.30
69 Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling. Am J Physiol Heart Circ Physiol 2005 1.25
70 Activation of the NLRP3 inflammasome by group B streptococci. J Immunol 2012 1.25
71 Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. J Neuroimmunol 2008 1.24
72 Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A 2013 1.23
73 MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria. Microbes Infect 2007 1.23
74 UNC93B1 mediates host resistance to infection with Toxoplasma gondii. PLoS Pathog 2010 1.22
75 Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cell Microbiol 2005 1.22
76 Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol 2008 1.22
77 Of mice and man: TLR11 (finally) finds profilin. Trends Immunol 2005 1.21
78 TLR9 and the recognition of self and non-self nucleic acids. Ann N Y Acad Sci 2006 1.18
79 Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J Biol Chem 2002 1.16
80 Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J Immunol 2010 1.12
81 Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. J Immunol 2003 1.12
82 Macrophages recognize streptococci through bacterial single-stranded RNA. EMBO Rep 2010 1.11
83 A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem 2009 1.09
84 Phagocytosis, innate immunity, and host-pathogen specificity. J Exp Med 2004 1.08
85 Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions. J Immunol 2011 1.08
86 Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque. J Periodontol 2008 1.06
87 MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA. J Biol Chem 2010 1.05
88 Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J Endotoxin Res 2005 1.05
89 TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One 2010 1.04
90 Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol 2011 1.04
91 Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi. J Immunol 2008 1.03
92 Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance. J Immunol 2006 1.03
93 Toll-like receptor 2 mediates persistent chemokine release by Chlamydia pneumoniae-infected vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2005 1.02
94 Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 2004 1.02
95 MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). J Leukoc Biol 2006 1.01
96 Innate immune recognition of lipopolysaccharide by endothelial cells. Crit Care Med 2002 1.00
97 The LPS receptor generates inflammatory signals from the cell surface. J Endotoxin Res 2003 0.99
98 TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like. Eur J Immunol 2010 0.99
99 Mechanisms of TLR9 activation. J Endotoxin Res 2004 0.99
100 Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein. J Biol Chem 2012 0.99
101 Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease. Infect Immun 2004 0.95
102 The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14. J Biol Chem 2007 0.95
103 Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation. AIDS Res Hum Retroviruses 2007 0.94
104 Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling. Blood 2008 0.94
105 Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo. J Immunol 2006 0.93
106 c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis. J Immunol 2006 0.92
107 Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs. Scand J Infect Dis 2003 0.92
108 Cell activation by Toll-like receptors: role of LBP and CD14. J Endotoxin Res 2004 0.91
109 Innate immune responses to Rhodococcus equi. J Immunol 2004 0.91
110 Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes. J Biol Chem 2011 0.90
111 Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun 2009 0.90
112 Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2. Am J Respir Crit Care Med 2004 0.90
113 A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A. J Biol Chem 2005 0.89
114 Toll-like receptor-dependent discrimination of streptococci. J Endotoxin Res 2006 0.89
115 Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice. Infect Immun 2003 0.89
116 The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog 2013 0.88
117 Immunology. The shape of things to come. Science 2007 0.87
118 LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia. Int Immunol 2004 0.86
119 Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells. J Immunol 2009 0.85
120 Adjuvants and their signaling pathways: beyond TLRs. Nat Immunol 2003 0.85
121 Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem 2013 0.83
122 Defective pro-IL-1β responses in macrophages from aged mice. Immun Ageing 2012 0.80
123 Receptor "cross talk" in innate immunity. J Clin Invest 2003 0.79
124 NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J Immunol 2011 0.78
125 Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling. Microbiol Immunol 2006 0.78
126 TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol 2014 0.77
127 Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection. Clin Immunol 2005 0.77
128 Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes. MBio 2014 0.76