Published in J Am Soc Hypertens on April 22, 2010
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Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension (2006) 2.89
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Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Nature (2002) 2.08
Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol (2011) 2.08
Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med (2012) 2.04
Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation (2004) 2.04
Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J Am Soc Nephrol (2007) 2.04
Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity. Diabetes (2009) 2.03
Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase. Arterioscler Thromb Vasc Biol (2002) 1.89
Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. J Am Soc Nephrol (2007) 1.87
Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism (2009) 1.86
Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol (2006) 1.86
Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. J Cardiovasc Electrophysiol (2002) 1.82
Adrenocortical zonation in humans under normal and pathological conditions. J Clin Endocrinol Metab (2010) 1.77
Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation (2002) 1.76
The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res (2010) 1.76
Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure. Hypertens Res (2011) 1.72
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol (2006) 1.67
Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration. Arterioscler Thromb Vasc Biol (2007) 1.63
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62
The role of mineralocorticoid receptor expression in brain remodeling after cerebral ischemia. Endocrinology (2008) 1.61
A case of atypical POEMS syndrome without polyneuropathy. Eur J Haematol (2008) 1.60
Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney. Hypertension (2006) 1.58
Beta cell dysfunction and its clinical significance in gestational diabetes. Endocr J (2010) 1.58
Multiple hepatic peribiliary cysts with cirrhosis. J Gastroenterol (2004) 1.57
KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria. J Clin Invest (2014) 1.54
Sema3A regulates bone-mass accrual through sensory innervations. Nature (2013) 1.53
Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. J Biol Chem (2008) 1.52
Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells. Atherosclerosis (2010) 1.52
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc Natl Acad Sci U S A (2010) 1.49
Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein. Arterioscler Thromb Vasc Biol (2003) 1.48
Change in β-cell mass in Japanese nondiabetic obese individuals. J Clin Endocrinol Metab (2013) 1.47
Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings. Hypertens Res (2008) 1.47
Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration. Proc Natl Acad Sci U S A (2003) 1.46
Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury. Hypertens Res (2007) 1.45
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. J Biol Chem (2010) 1.45
Coronary microcirculatory dysfunction in aortic stenosis: myocardial contrast echocardiography study. Ann Thorac Surg (2009) 1.44
Feasibility of regression of hypertension using contemporary antihypertensive agents. Am J Hypertens (2013) 1.44
Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells. FEBS Lett (2009) 1.43
Transcatheter closure of atrial septal defect in a geriatric population. Catheter Cardiovasc Interv (2012) 1.43
Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem Biophys Res Commun (2008) 1.42
Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension. Hypertens Res (2010) 1.39
Augmentation of neovascularization [corrected] in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells. PLoS One (2008) 1.36
Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A (2006) 1.35
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer Res (2011) 1.33
Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2. Circ Res (2007) 1.31
Snail1 is involved in the renal epithelial-mesenchymal transition. Biochem Biophys Res Commun (2007) 1.29
Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Arterioscler Thromb Vasc Biol (2005) 1.27
Runx1 and Runx2 cooperate during sternal morphogenesis. Development (2010) 1.24
(Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation. Diabetes (2009) 1.24
(Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hypertens Res (2007) 1.21
A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J (2003) 1.21
Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol (2006) 1.21
The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol (2004) 1.20
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta. Mol Cell Biol (2005) 1.20
Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor. Cancer Metastasis Rev (2003) 1.19
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem (2005) 1.19
Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro. Biochem Biophys Res Commun (2009) 1.19
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. Circulation (2012) 1.18
[Successful treatment in a case of podostroma cornu-damae poisoning, a deadly poisonous mushroom]. Chudoku Kenkyu (2002) 1.18
Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK. J Biol Chem (2003) 1.17
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC. Oncol Rep (2010) 1.14
Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation (2013) 1.13
Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation (2002) 1.13
Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes. Endocr J (2011) 1.11
Functions and regulatory mechanisms of Gq-signaling pathways. Neurosignals (2009) 1.10
High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein. Kidney Int (2010) 1.10
Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control. Diabetes (2008) 1.10
The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell Signal (2007) 1.09
Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. Genes Cells (2006) 1.09
NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats. Am J Physiol Regul Integr Comp Physiol (2007) 1.09
Serum alpha-1-acid glycoprotein concentration in clinically healthy puppies and adult dogs and in dogs with various diseases. Vet Clin Pathol (2009) 1.08
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. Eur J Pharmacol (2004) 1.07
Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front. J Neurosurg Spine (2007) 1.07
Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy. Circ Res (2003) 1.07
Determinants of decline in glomerular filtration rate in nonproteinuric subjects with or without diabetes and hypertension. Clin J Am Soc Nephrol (2009) 1.06
Adrenomedullin promotes proliferation and migration of cultured endothelial cells. Hypertens Res (2003) 1.06
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab (2010) 1.06
Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage. Blood (2002) 1.05
The (pro)renin receptor and the kidney. Semin Nephrol (2007) 1.05
High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men. Metabolism (2007) 1.04
Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. Mol Cell Biol (2003) 1.04
Atelocollagen for protein and gene delivery. Adv Drug Deliv Rev (2003) 1.04
Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis. Am J Physiol Gastrointest Liver Physiol (2008) 1.04
Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells. J Biol Chem (2009) 1.04
Angiotensin II type 2 receptor blockade increases bone mass. J Biol Chem (2008) 1.03
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem (2002) 1.03
CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42. J Neurosci (2006) 1.03
Involvement of (pro)renin receptor in the glomerular filtration barrier. J Mol Med (Berl) (2008) 1.03
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis. J Biol Chem (2007) 1.03
Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes. Am J Hypertens (2010) 1.03
High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men. Metabolism (2009) 1.02