Published in J Med Chem on May 27, 2010
HIV-1 antiretroviral drug therapy. Cold Spring Harb Perspect Med (2012) 2.18
Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Med Chem Lett (2012) 1.52
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors. Antimicrob Agents Chemother (2011) 1.16
Current perspectives on HIV-1 antiretroviral drug resistance. Viruses (2014) 1.04
Biochemical mechanism of HIV-1 resistance to rilpivirine. J Biol Chem (2012) 0.99
Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. J Med Chem (2010) 0.95
Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine. Antimicrob Agents Chemother (2013) 0.94
Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants. J Med Chem (2015) 0.93
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An update on clinical utility of rilpivirine in the management of HIV infection in treatment-naïve patients. HIV AIDS (Auckl) (2013) 0.84
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Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. ACS Chem Biol (2015) 0.81
Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus. J Med Chem (2016) 0.79
Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother (2013) 0.78
Double Variational Binding--(SMILES) Conformational Analysis by Docking Mechanisms for Anti-HIV Pyrimidine Ligands. Int J Mol Sci (2015) 0.78
Protein-mediated antagonism between HIV reverse transcriptase ligands nevirapine and MgATP. Biophys J (2013) 0.77
A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochim Biophys Acta (2014) 0.76
Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis. Nucleic Acids Res (2015) 0.76
Identification of a novel sulfonamide non-nucleoside reverse transcriptase inhibitor by a phenotypic HIV-1 full replication assay. PLoS One (2013) 0.76
Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. ACS Med Chem Lett (2012) 0.76
New option for management of HIV-1 infection in treatment-naive patients: once-daily, fixed-dose combination of rilpivirine-emtricitabine-tenofovir. HIV AIDS (Auckl) (2012) 0.76
Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Biomolecules (2013) 0.75
NMR structure of the HIV-1 reverse transcriptase thumb subdomain. J Biomol NMR (2016) 0.75
Conformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study. Biochemistry (2016) 0.75
Pyridones as NNRTIs against HIV-1 mutants: 3D-QSAR and protein informatics. J Comput Aided Mol Des (2013) 0.75
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing. Proc Natl Acad Sci U S A (2013) 3.35
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature (2003) 2.81
Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet (2012) 2.39
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature (2006) 1.81
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action. J Biol Chem (2012) 1.52
Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV. J Mol Biol (2010) 1.38
The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activity. Proc Natl Acad Sci U S A (2002) 1.37
Molecular basis for negative regulation of the glucagon receptor. Proc Natl Acad Sci U S A (2012) 1.33
Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors. Antiviral Res (2002) 1.27
Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing. PLoS One (2010) 1.27
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem (2013) 1.26
Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis. Biochemistry (2006) 1.26
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem (2009) 1.24
Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J Mol Biol (2010) 1.23
The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation. J Acquir Immune Defic Syndr (2008) 1.19
Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness. PLoS One (2011) 1.19
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT. AIDS (2005) 1.17
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. J Neurochem (2013) 1.16
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors. Antimicrob Agents Chemother (2011) 1.16
Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. Antimicrob Agents Chemother (2006) 1.14
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci U S A (2009) 1.14
Development of a dissolution medium for nimodipine tablets based on bioavailability evaluation. Eur J Pharm Sci (2004) 1.12
Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling. BMC Genomics (2010) 1.11
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma. Clin Cancer Res (2008) 1.10
Development of a chemically stable 10-hydroxycamptothecin nanosuspensions. Int J Pharm (2009) 1.07
Motor domain mutation traps kinesin as a microtubule rigor complex. Biochemistry (2003) 1.06
MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen. Hepatology (2012) 1.05
The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V. Antivir Chem Chemother (2007) 1.05
Solid self-emulsifying nitrendipine pellets: preparation and in vitro/in vivo evaluation. Int J Pharm (2009) 1.02
Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex. J Biol Chem (2009) 1.01
Cardiac papillary fibroelastoma: a retrospect of four cases. J Cardiothorac Surg (2013) 1.00
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring. J Mol Biol (2006) 1.00
HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75. Biochemistry (2007) 0.99
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Antimicrob Agents Chemother (2007) 0.99
Mechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells. J Biol Chem (2009) 0.98
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases. Mol Pharmacol (2008) 0.97
Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. BMC Cell Biol (2004) 0.97
In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile. Antimicrob Agents Chemother (2011) 0.96
T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties. J Biol Chem (2008) 0.96
Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother (2014) 0.94
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem (2012) 0.94
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties. J Mol Biol (2010) 0.93
Selection of euploid blastocysts for cryopreservation with array comparative genomic hybridization (aCGH) results in increased implantation rates in subsequent frozen and thawed embryo transfer cycles. Mol Cytogenet (2013) 0.92
A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly. Biochemistry (2012) 0.92
Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. Pediatrics (2008) 0.92
Integrative analysis of porcine microRNAome during skeletal muscle development. PLoS One (2013) 0.92
Inhibiting aurora kinases reduces tumor growth and suppresses tumor recurrence after chemotherapy in patient-derived triple-negative breast cancer xenografts. Mol Cancer Ther (2012) 0.91
Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs. Virol J (2011) 0.91
Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One (2013) 0.90
Selection of competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing for patients undergoing preimplantation genetic screening: a prospective study with sibling oocytes. BMC Med Genomics (2014) 0.90
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother (2009) 0.89
Preparation and characterization of a submicron lipid emulsion of docetaxel: submicron lipid emulsion of docetaxel. Drug Dev Ind Pharm (2008) 0.88
Codon optimization of human parvovirus B19 capsid genes greatly increases their expression in nonpermissive cells. J Virol (2010) 0.88
Three routes to suppression of the neurodegenerative phenotypes caused by kinesin heavy chain mutations. Genetics (2012) 0.87
Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. J Immunol (2005) 0.87
The role of glucosensing neurons in the detection of hypoglycemia. Diabetes Technol Ther (2004) 0.87
Stress, coping and suicide ideation in Chinese college students. J Adolesc (2011) 0.87
Amino terminus of Plasmodium falciparum acidic basic repeat antigen interacts with the erythrocyte membrane through band 3 protein. Mol Biochem Parasitol (2002) 0.86
Molecular recognition between 4a S/R-galanthamine diastereoisomers and alpha-cyclodextrin. J Mol Model (2003) 0.86
Array comparative genomic hybridization screening in IVF significantly reduces number of embryos available for cryopreservation. Clin Exp Reprod Med (2012) 0.86
Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population. Neurol Res (2014) 0.86
Mechanisms of hypotonicity-induced calcium signaling and integrin activation by arachidonic acid-derived inflammatory mediators in B cells. J Immunol (2005) 0.85
R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase. J Biol Chem (2005) 0.85
Infantile seizures and other epileptic phenotypes in a Chinese family with a missense mutation of KCNQ2. Eur J Pediatr (2006) 0.85
Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by two-dimensional fluorescence difference gel electrophoresis. Virol J (2010) 0.85
Large-scale functional purification of recombinant HIV-1 capsid. PLoS One (2013) 0.85
Job satisfaction, occupational commitment and intent to stay among Chinese nurses: a cross-sectional questionnaire survey. J Adv Nurs (2011) 0.84
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines. J Med Chem (2011) 0.84
Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors. Antivir Ther (2014) 0.84
Preparation and in vitro/in vivo evaluation of fenofibrate nanocrystals. Int J Pharm (2013) 0.84
Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. Mol Nutr Food Res (2010) 0.84
Extensive regenerative plasticity among adult NG2-glia populations is exclusively based on self-renewal. Glia (2013) 0.83
Job satisfaction in mainland China: comparing critical care nurses and general ward nurses. J Adv Nurs (2012) 0.83
Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191. Antimicrob Agents Chemother (2011) 0.83