|
1
|
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.
|
Nat Med
|
2006
|
2.28
|
|
2
|
Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate.
|
J Neurosci
|
2006
|
1.70
|
|
3
|
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
|
EMBO J
|
2007
|
1.49
|
|
4
|
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
|
J Biol Chem
|
2002
|
1.34
|
|
5
|
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.
|
J Psychiatry Neurosci
|
2004
|
1.30
|
|
6
|
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
|
J Biol Chem
|
2002
|
1.26
|
|
7
|
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
|
J Biol Chem
|
2004
|
1.23
|
|
8
|
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.
|
J Neurosci
|
2009
|
1.19
|
|
9
|
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice.
|
Neurobiol Aging
|
2010
|
1.03
|
|
10
|
Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease.
|
J Neurosci
|
2009
|
0.95
|
|
11
|
The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations.
|
J Lipid Res
|
2007
|
0.95
|
|
12
|
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
|
J Biol Chem
|
2003
|
0.84
|
|
13
|
Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice.
|
Neurosci Lett
|
2011
|
0.81
|
|
14
|
Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.
|
Neuropsychopharmacology
|
2012
|
0.80
|
|
15
|
Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.
|
J Biol Chem
|
2013
|
0.79
|
|
16
|
Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.
|
Neurochem Res
|
2008
|
0.79
|
|
17
|
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
|
Proc Natl Acad Sci U S A
|
2002
|
0.79
|
|
18
|
The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors.
|
Behav Brain Res
|
2010
|
0.76
|
|
19
|
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase.
|
Neurosci Lett
|
2010
|
0.75
|