Less is more: how less health care can result in better health.

Risk of thyroid cancer based on thyroid ultrasound imaging characteristics: results of a population-based study. JAMA Intern Med (2013) 3.62

Understanding provision of chemotherapy to patients with end stage cancer: qualitative interview study. BMJ (2011) 1.77

Time to revive the GP-focused clinical examination. Br J Gen Pract (2017) 1.56

"Well, I think there is great variation...": a qualitative study of oncologists' experiences and views regarding medical criteria and other factors relevant to treatment decisions in advanced cancer. Oncologist (2013) 1.31

Towards understanding the de-adoption of low-value clinical practices: a scoping review. BMC Med (2015) 1.07

An official American Thoracic Society/American College of Chest Physicians policy statement: the Choosing Wisely top five list in adult pulmonary medicine. Chest (2014) 0.98

Choosing wisely: avoiding too much medicine. Can Fam Physician (2014) 0.97

Trends and interaction of polypharmacy and potentially inappropriate prescribing in primary care over 15 years in Ireland: a repeated cross-sectional study. BMJ Open (2015) 0.90

What do you think overdiagnosis means? A qualitative analysis of responses from a national community survey of Australians. BMJ Open (2015) 0.86

Physicians' beliefs about breast cancer surveillance testing are consistent with test overuse. Med Care (2013) 0.86

The effects of comorbidity on the benefits and harms of treatment for chronic disease: a systematic review. PLoS One (2014) 0.84

Variation in resource utilization for the management of uncomplicated community-acquired pneumonia across community and children's hospitals. J Pediatr (2014) 0.81

Trends in childbirth before 39 weeks' gestation without medical indication. Med Care (2014) 0.80

"The ultimate decision is yours": exploring patients' attitudes about the overuse of medical interventions. PLoS One (2012) 0.80

Endpoint selection and relative (versus absolute) risk reporting in published medication trials. J Gen Intern Med (2011) 0.79

The cycle of bias in health research: a framework and toolbox for critical appraisal training. Account Res (2013) 0.78

Climate change, human health, and epidemiological transition. Prev Med (2014) 0.78

Organising medication discontinuation: a qualitative study exploring the views of general practitioners toward discontinuing statins. BMC Health Serv Res (2016) 0.75

Another Pill, Another Test, and Another Procedure: One Resident's Reflection on Healthcare Cost Containment. Glob Adv Health Med (2015) 0.75

Beyond the "Choosing wisely": a possible attempt. Ital J Pediatr (2016) 0.75

Race/ethnicity, and Americans' perceptions and experiences of over- and under-use of care: a cross-sectional study. BMC Health Serv Res (2015) 0.75

Use of Prescription Drugs and Investigations by Doctors in Primary Care Settings in Oman and the UK. Sultan Qaboos Univ Med J (2016) 0.75

Appropriateness in allergic respiratory diseases health care in Italy: definitions and organizational aspects. Clin Mol Allergy (2016) 0.75

Determinants of the overuse of imaging in low-risk prostate cancer: A systematic review. Urol Oncol (2017) 0.75

Consistency and sources of divergence in recommendations on screening with questionnaires for presently experienced health problems or symptoms: a comparison of recommendations from the Canadian Task Force on Preventive Health Care, UK National Screening Committee, and US Preventive Services Task Force. BMC Med (2017) 0.75

Systematic overuse of healthcare services: a conceptual model. Appl Health Econ Health Policy (2015) 0.75

Overtreatment in the United States. PLoS One (2017) 0.75

Low diagnostic yield of elective coronary angiography. N Engl J Med (2010) 9.38

ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol (2006) 7.77

Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med (2006) 6.14

Weight loss to treat urinary incontinence in overweight and obese women. N Engl J Med (2009) 5.58

ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol (2007) 5.40

Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (2003) 5.38

ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography). Circulation (2007) 4.66

Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation (2007) 4.16

The sensitivity and specificity of a simple test to distinguish between urge and stress urinary incontinence. Ann Intern Med (2006) 3.93

Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. JAMA (2003) 3.64

Frequency of stress testing to document ischemia prior to elective percutaneous coronary intervention. JAMA (2008) 3.62

Evidence-based guidelines for cardiovascular disease prevention in women. Circulation (2004) 3.39

Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA (2002) 3.13

Oophorectomy vs ovarian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women's Health Initiative Observational Study. Arch Intern Med (2011) 3.00

Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial. JAMA (2002) 2.73

Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysis. Arch Intern Med (2002) 2.69

The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography: a meta-analysis. J Am Coll Cardiol (2006) 2.64

Mandatory anesthesia. JAMA Intern Med (2013) 2.62

Strength of study evidence examined by the FDA in premarket approval of cardiovascular devices. JAMA (2009) 2.55

Diagnostic tests: another frontier for less is more: or why talking to your patient is a safe and effective method of reassurance. Arch Intern Med (2010) 2.49

Medical devices--balancing regulation and innovation. N Engl J Med (2011) 2.45

Variations between clinical trial participants and Medicare beneficiaries in evidence used for Medicare national coverage decisions. Arch Intern Med (2008) 2.43

Effects of the selective estrogen receptor modulator raloxifene on coronary outcomes in the Raloxifene Use for The Heart trial: results of subgroup analyses by age and other factors. Circulation (2009) 2.41

Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol (2002) 2.41

Evaluation of abnormal mammography results and palpable breast abnormalities. Ann Intern Med (2003) 2.20

Hot flushes, coronary heart disease, and hormone therapy in postmenopausal women. Menopause (2009) 2.07

Cardiologists' use of percutaneous coronary interventions for stable coronary artery disease. Arch Intern Med (2007) 2.02

Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: Consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation (2005) 1.97

Postmenopausal hormone therapy: does it cause incontinence? Obstet Gynecol (2005) 1.94

Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. Circulation (2006) 1.93

Accelerated approval and possible withdrawal of midodrine. JAMA (2010) 1.88

Patterns and intensity of medical therapy in patients undergoing percutaneous coronary intervention. JAMA (2011) 1.88

Effect of the Women's Health Initiative on women's decisions to discontinue postmenopausal hormone therapy. Obstet Gynecol (2003) 1.85

Low rate of sex-specific result reporting in cardiovascular trials. Mayo Clin Proc (2007) 1.84

ACC/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with chronic heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Heart Failure Clinical Data Standards): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Failure Society of America. Circulation (2005) 1.78

Coronary CT angiography for acute chest pain. N Engl J Med (2012) 1.78

Comparison of methods to measure low serum estradiol levels in postmenopausal women. J Clin Endocrinol Metab (2006) 1.76

Predictors of heart failure among women with coronary disease. Circulation (2004) 1.74

Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. J Am Coll Cardiol (2007) 1.69

Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association. Circulation (2014) 1.67

Disparities in use of implantable cardioverter-defibrillators: moving beyond process measures to outcomes data. JAMA (2007) 1.66

The WHI estrogen-alone trial--do things look any better? JAMA (2004) 1.64

Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial. Am J Psychiatry (2005) 1.62

Gender bias in studies for Food and Drug Administration premarket approval of cardiovascular devices. Circ Cardiovasc Qual Outcomes (2011) 1.61

CMS's landmark decision on CT colonography--examining the relevant data. N Engl J Med (2009) 1.61

Sex hormone levels and risk of breast cancer with estrogen plus progestin. J Natl Cancer Inst (2013) 1.60

Evidence-based guidelines for cardiovascular disease prevention in women. J Am Coll Cardiol (2004) 1.59

Menopausal symptoms in older women and the effects of treatment with hormone therapy. Obstet Gynecol (2002) 1.57

Is diabetes mellitus a heart disease equivalent in women? Results from an international study of postmenopausal women in the Raloxifene Use for the Heart (RUTH) Trial. Circ Cardiovasc Qual Outcomes (2013) 1.55

AHA/ACCF [corrected] 2009 performance measures for primary prevention of cardiovascular disease in adults: a report of the American College of Cardiology Foundation/American Heart Association task force on performance measures (writing committee to develop performance measures for primary prevention of cardiovascular disease): developed in collaboration with the American Academy of Family Physicians; American Association of Cardiovascular and Pulmonary Rehabilitation; and Preventive Cardiovascular Nurses Association: endorsed by the American College of Preventive Medicine, American College of Sports Medicine, and Society for Women's Health Research. Circulation (2009) 1.54

The "costs" of urinary incontinence for women. Obstet Gynecol (2006) 1.52

Opioids for chronic pain. Arch Intern Med (2011) 1.52

Evidence-based guidelines for cardiovascular disease prevention in women. American Heart Association scientific statement. Arterioscler Thromb Vasc Biol (2004) 1.49

Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with coronary disease. Arterioscler Thromb Vasc Biol (2002) 1.48

ACC/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Data Standards on Atrial Fibrillation). Circulation (2004) 1.45

Noninvasive cardiac imaging. Am Fam Physician (2007) 1.45

Evidence of pharmaceutical innovation and therapeutic enthusiasm: strategies for patent extension. Arch Intern Med (2012) 1.43

Reconsidering transfer for percutaneous coronary intervention strategy: time is of the essence. Arch Intern Med (2011) 1.42

Mortality in Medicare patients undergoing elective percutaneous coronary intervention with or without antecedent stress testing. Circ Cardiovasc Qual Outcomes (2013) 1.41

Coronary artery calcium: should we rely on this surrogate marker? Circulation (2006) 1.40

First physical. Arch Intern Med (2010) 1.39

Why is a good clinical prediction rule so hard to find? Arch Intern Med (2011) 1.38

The 510(k) ancestry of a metal-on-metal hip implant. N Engl J Med (2013) 1.36

Editor's Note--to make the case--evidence is required: comment on "Making the case for selective use of statins in the primary prevention setting". Arch Intern Med (2011) 1.33

Effect of weight loss on urinary incontinence in overweight and obese women: results at 12 and 18 months. J Urol (2010) 1.31

ACC/AHA/HRS 2006 key data elements and definitions for electrophysiological studies and procedures: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (ACC/AHA/HRS Writing Committee to Develop Data Standards on Electrophysiology). Circulation (2006) 1.29

Persistent hot flushes in older postmenopausal women. Arch Intern Med (2008) 1.28

Inclusion of comparative effectiveness data in high-risk cardiovascular device studies at the time of premarket approval. JAMA (2012) 1.26

Presumed safe no more: lessons from the Wingspan saga on regulation of devices. BMJ (2014) 1.23

Frequency and severity of hot flashes and sleep disturbance in postmenopausal women with hot flashes. Menopause (2009) 1.23

Feasibility and acceptability of restorative yoga for treatment of hot flushes: a pilot trial. Maturitas (2006) 1.22

A systematic review of gender differences in mortality after coronary artery bypass graft surgery and percutaneous coronary interventions. Clin Cardiol (2007) 1.16

ACCF/AHA 2009 performance measures for primary prevention of cardiovascular disease in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for Primary Prevention of Cardiovascular Disease) developed in collaboration with the American Academy of Family Physicians; American Association of Cardiovascular and Pulmonary Rehabilitation; and Preventive Cardiovascular Nurses Association: endorsed by the American College of Preventive Medicine, American College of Sports Medicine, and Society for Women's Health Research. J Am Coll Cardiol (2009) 1.16

Premarket approval supplement pathway: do we know what we are getting? Ann Intern Med (2014) 1.14

Exercise blood pressure and future cardiovascular death in asymptomatic individuals. Circulation (2010) 1.11

Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women. Biol Psychiatry (2002) 1.11

Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of life. Arch Neurol (2006) 1.10

Enhanced risk assessment in asymptomatic individuals with exercise testing and Framingham risk scores. Circulation (2005) 1.10

Association of total and central obesity with mortality in postmenopausal women with coronary heart disease. Am J Epidemiol (2003) 1.10

Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease. Am J Cardiol (2011) 1.09

Commentary: Improving participant recruitment in clinical and translational research. Acad Med (2011) 1.09

Dopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD): increased prevalence of the 2-repeat allele. Am J Med Genet B Neuropsychiatr Genet (2005) 1.08

Cancer risks and radiation exposure from computed tomographic scans: how can we be sure that the benefits outweigh the risks? Arch Intern Med (2009) 1.07

ACC/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Commitee to Develop Data Standards on Atrial Fibrillation). J Am Coll Cardiol (2004) 1.07

Effects of ultralow-dose transdermal estradiol on bone mineral density: a randomized clinical trial. Obstet Gynecol (2004) 1.06

ACC/AHA/HRS 2006 key data elements and definitions for electrophysiological studies and procedures: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (ACC/AHA/HRS Writing Committee to Develop Data Standards on Electrophysiology). J Am Coll Cardiol (2006) 1.05

Screening asymptomatic diabetic patients for coronary artery disease: why not? J Am Coll Cardiol (2006) 1.04

The rise and fall of menopausal hormone therapy. Annu Rev Public Health (2005) 1.04

Approaches to enhancing radiation safety in cardiovascular imaging: a scientific statement from the American Heart Association. Circulation (2014) 1.04

A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat (2010) 1.03

Adaptive statistical iterative reconstruction reduces patient radiation dose in neuroradiology CT studies. Neuroradiology (2014) 1.01

Why physicians favor use of percutaneous coronary intervention to medical therapy: a focus group study. J Gen Intern Med (2008) 1.01

An intensive behavioral weight loss intervention and hot flushes in women. Arch Intern Med (2010) 1.00

Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial. Metab Syndr Relat Disord (2008) 1.00

Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: executive summary. Circulation (2004) 0.98

Effect of raloxifene on stroke and venous thromboembolism according to subgroups in postmenopausal women at increased risk of coronary heart disease. Stroke (2008) 0.97

Baseline characteristics of participants in the Raloxifene Use for The Heart (RUTH) trial. Am J Cardiol (2002) 0.96

On Chlorofluorocarbon Bans and Inhaled Albuterol Prices. JAMA Intern Med (2015) 0.96