Published in Autophagy on July 01, 2010
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When autophagy meets cancer through p62/SQSTM1. Am J Cancer Res (2012) 1.58
Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis (2010) 1.17
Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy. Front Oncol (2013) 1.08
Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell Death Dis (2014) 1.08
Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation. Cancer Cell Int (2014) 0.90
Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. Mitochondrion (2012) 0.87
The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy (2012) 0.86
Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. Autophagy (2012) 0.86
Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells. Anticancer Res (2014) 0.85
QSOX1 inhibits autophagic flux in breast cancer cells. PLoS One (2014) 0.85
Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells. PLoS One (2015) 0.84
Modulation of protein quality control systems by food phytochemicals. J Clin Biochem Nutr (2013) 0.78
Targeting metabolism and autophagy in the context of haematologic malignancies. Int J Cell Biol (2012) 0.77
The multiple mechanisms of cell death triggered by resveratrol in lymphoma and leukemia. Int J Mol Sci (2014) 0.77
Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus. Cell Death Dis (2016) 0.77
Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes. Arch Toxicol (2014) 0.75
Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds. Int J Mol Sci (2017) 0.75
The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms. Nutrients (2016) 0.75
Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells. Curr Genomics (2017) 0.75
Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells. J Ginseng Res (2016) 0.75
Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin. Mar Drugs (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene (2003) 3.96
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res (2011) 2.93
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res (2010) 2.60
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood (2013) 2.38
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res (2010) 2.02
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions. Blood (2012) 1.77
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Oncogene (2004) 1.67
Hypomethylating agents reactivate FOXO3A in acute myeloid leukemia. Cell Cycle (2011) 1.59
When autophagy meets cancer through p62/SQSTM1. Am J Cancer Res (2012) 1.58
Azacitidine-resistant SKM1 myeloid cells are defective for AZA-induced mitochondrial apoptosis and autophagy. Cell Cycle (2011) 1.53
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line. Autophagy (2009) 1.29
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res (2006) 1.27
Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage. FASEB J (2003) 1.19
Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol. FASEB J (2008) 1.17
Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway. J Immunol (2004) 1.16
Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells. Oncotarget (2011) 1.15
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One (2009) 1.13
Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy. Haematologica (2011) 1.08
Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness. J Mol Cell Biol (2012) 1.06
Targeting autophagy to fight hematopoietic malignancies. Cell Cycle (2010) 1.06
Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC. Cancer Res (2010) 1.06
Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors. Mol Cancer Ther (2009) 1.05
Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death. Glycobiology (2003) 1.05
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases. Oncogene (2003) 1.04
Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway. J Biol Chem (2006) 1.04
Nephroblastoma overexpressed/cysteine-rich protein 61/connective tissue growth factor/nephroblastoma overexpressed gene-3 (NOV/CCN3), a selective adrenocortical cell proapoptotic factor, is down-regulated in childhood adrenocortical tumors. J Clin Endocrinol Metab (2007) 1.04
Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia. Blood (2004) 1.02
The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis. Genes Dev (2005) 1.02
Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation. Haematologica (2013) 1.00
BCL2L10 is a predictive factor for resistance to azacitidine in MDS and AML patients. Oncotarget (2012) 1.00
Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells. Cancer Res (2009) 0.98
Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway. J Biol Chem (2002) 0.97
Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties. Cell Cycle (2013) 0.94
Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity. Cell Microbiol (2010) 0.93
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. J Biol Chem (2005) 0.92
Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability. Infect Immun (2009) 0.92
All tyrosine kinase inhibitor-resistant chronic myelogenous cells are highly sensitive to ponatinib. Oncotarget (2012) 0.91
Increased rate of apoptosis and diminished phagocytic ability of human neutrophils infected with Afa/Dr diffusely adhering Escherichia coli strains. Infect Immun (2004) 0.90
The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation. Oncogene (2002) 0.89
Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor. FASEB J (2001) 0.89
RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation. Eur J Immunol (2002) 0.89
The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis. FASEB J (2003) 0.89
Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness. PLoS One (2009) 0.88
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy (2015) 0.87
The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy (2012) 0.86
Involvement of mast cells in gastritis caused by Helicobacter pylori: a potential role in epithelial cell apoptosis. J Clin Pathol (2007) 0.84
Blocking NF-kappaB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector. Oncogene (2002) 0.84
Mechanism of action of the multikinase inhibitor Foretinib. Cell Cycle (2011) 0.84
Isoform-specific contribution of protein kinase C to prion processing. Mol Cell Neurosci (2008) 0.84
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice. EMBO J (2009) 0.83
Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms. J Biol Chem (2004) 0.82
Proper macrophagic differentiation requires both autophagy and caspase activation. Autophagy (2012) 0.81
Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase. Int J Cancer (2003) 0.81
Fas ligand expression following normothermic liver ischemia-reperfusion. J Surg Res (2005) 0.81
Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway. Oncotarget (2012) 0.81
Monosomal karyotype improves IPSS-R stratification in MDS and AML patients treated with Azacitidine. Am J Hematol (2013) 0.81
Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly. J Leukoc Biol (2008) 0.80
A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus. Mar Drugs (2011) 0.79
Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. Langenbecks Arch Surg (2008) 0.78
Inhibition of apoptosis induced by heat shock preconditioning is associated with decreased phagocytosis in human polymorphonuclear leukocytes through inhibition of Rac and Cdc42. Immunol Cell Biol (2007) 0.78
Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling. PLoS One (2012) 0.78
Ponatinib circumvents all types of imatinib resistance in chronic myelogenous leukemia cell lines. Cell Cycle (2013) 0.78
Effect of caspase inhibition on thymic apoptosis in hemorrhagic shock. J Invest Surg (2007) 0.77
cIAPs and XIAP reduce RIPKs to silence. Blood (2014) 0.77
How recent advances in high-risk myelodysplastic syndrome physiopathology may impact future treatments. Curr Pharm Des (2013) 0.77
Human polymorphonuclear leukocytes are sensitive in vitro to Helicobacter pylori vaca toxin. Helicobacter (2006) 0.76
Rho GTPase is activated by cytotoxic necrotizing factor 1 in peripheral blood T lymphocytes: potential cytotoxicity for intestinal epithelial cells. Infect Immun (2003) 0.76
Nepheliosyne B, a new polyacetylenic acid from the new caledonian marine sponge Niphates sp. Mar Drugs (2013) 0.75
Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis. Ultrason Sonochem (2012) 0.75
Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae. Magn Reson Chem (2011) 0.75